A5101398908- Toxin Mechanisms and Immunotoxins
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Prostate Cancer Treatment and Research
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Microbial Inactivation Methods
- Analytical Chemistry and Sensors
- Microbial infections and disease research
- Renal cell carcinoma treatment
- Ultrasound and Hyperthermia Applications
- Esophageal and GI Pathology
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Electrochemical sensors and biosensors
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Sensors and Ion Detection
- Bacillus and Francisella bacterial research
- Transgenic Plants and Applications
- Advanced biosensing and bioanalysis techniques
- Biliary and Gastrointestinal Fistulas
- Mycotoxins in Agriculture and Food
- Molecular Biology Techniques and Applications
- Renal and related cancers
- Ultrasound Imaging and Elastography
University College London
2024
Sheffield Children's NHS Foundation Trust
2023
Sheffield Teaching Hospitals NHS Foundation Trust
2016-2023
University of Illinois Chicago
2020-2022
University of Illinois Urbana-Champaign
2020
Center for Cancer Research
2016-2019
University of Wisconsin System
2018
New York University
2018
Arizona State University
2013-2017
University of Wisconsin–Madison
2001-2017
Endostatin is the first endogenous angiogenesis inhibitor to enter clinical trials. Laboratory investigations with endostatin have indicated broad antitumor activity coupled remarkably low toxicity. A phase I trial of recombinant human was designed evaluate toxicity and explore biologic effectiveness in patients refractory solid tumors.Endostatin administered as a 1-hour intravenous infusion given daily for 28-day cycle. starting dose 30 mg/m2 explored subsequent escalations 60, 100, 150,...
Focal prostate cryoablation is the less-than-complete ablation of gland with ice. Known tumor ablated aggressively, whereas contralateral tissue and surrounding structures are spared. This method offers targeted local cancer control aiming at sexual potency urinary continence preservation in patients whose believed to be unilateral.Patients who had a strong desire for function were informed focal as an investigational treatment option clinically organ-confined, unilateral identified by color...
Abstract Regulation of intracellular potassium (K + ) concentration plays a key role in metabolic processes. So far, only few K sensors have been developed. The highly selective fluorescent sensor KS6 for monitoring ion dynamics mitochondria was produced by coupling triphenylphosphonium, borondipyrromethene (BODIPY), and triazacryptand (TAC). shows good response to the range 30–500 m M , large dynamic ( F max / 0 ≈130), high brightness ϕ f =14.4 % at 150 ), insensitivity both pH 5.5–9.0...
Background: Given the complexity of managing hepatocellular carcinoma (HCC), it is widely accepted that a multidisciplinary team approach (tumor boards) offers best to individualize therapy. The aim this study was determine utilization therapies and outcomes for patients with HCC, comparing those managed through our tumor board (MDTB) who were not. Methods: A database analysis all HCC MDTB, from 2007 until 2011, performed. 2002 not similarly created. Results: total 306 2011 in comparison 349...
The extracellular matrix (ECM) is a complex and dynamic meshwork of proteins providing structural support to cells. It also provides biochemical signals governing cellular processes, including proliferation, adhesion, migration. Alterations ECM structure and/or composition have been linked many pathological cancer fibrosis. Over the past decade, mass-spectrometry-based proteomics has become state-of-the-art method profile protein ECMs. However, existing methods do not fully capture broad...
A comparative genetic analysis of SIV-infected female macaques during the first 120 days postinfection was undertaken. The same dose a macaque-passaged SIVmac239(nef open) administered to three intravenously (IV) and intravaginally (IVAG). Clinical outcomes observed ranged from rapid nonprogression, while two IV-infected developed an uncommon hindleg paresis. Analysis viral load (bDNA assay) determined that both IV- IVAG-infected had comparable high loads at peak 14 postinfection. study...
An urgent need exists to prevent the sexual transmission of HIV-1. With prevalence rates exceeding 35% in parts sub-Saharan Africa, increasing attention has been placed on developing and testing microbicidal agents capable preventing virus at mucosal sites. HIV-1 microbicides must meet several requirements before their widespread use. The drugs be able neutralize a diversity strains, not induce inflammation, associated with minimal side effects, effective for prolonged period after single...
A study was conducted to compare results of transrectal ultrasound with pathologic findings on 116 patients who underwent radical prostatectomy for treatment prostate cancer. In 96% (111 116), guided biopsies a hypoechoic lesion proved cancer; seven had known Stage one patient cancer detected by palpation and not ultrasound. Cancers in the outer gland (peripheral central zones) were compared cancers inner (transition zone) both pathology. Forty-eight percent (52 108) originating showed...
Methods.The diagnostic performance of transrectal ultrasound (TRUS) gland volume and prostate specific antigen (PSA) results were evaluated in 204 men consecutively scheduled to undergo transurethral prostatic resection (TUR).Nonpalpable cancer was detected by TRUS alone 18% (29 161) TUR 9% (14/161), for an overall incidence 27%.A predicted PSA value (TRUS X 0.20 ng/ml/g = polyclonal PSA) used comparison with serum each patient.TRUS positive predictive improved from 52% 86% when exceeded the...
Extracellular pH has a strong effect on cell metabolism and growth. Precisely detecting extracellular with high throughput is critical for research fermentation applications. In this research, series of ratiometric fluorescent sensitive polymers are developed the ps-pH-neutral characterized as best one exculsive detection pH. Poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) used host polymer to increase water solubility without introducing toxicity. The emission spectra from polymeric sensor...
Histotripsy fractionates tissue through a mechanical, non-invasive ultrasonic ablation process that precisely controls acoustic cavitation while utilizing real-time ultrasound (US) imaging guidance. This study investigates the potential, feasibility and tumor volume reduction effects of histotripsy for liver cancer in subcutaneous vivo murine Hepatocellular Carcinoma (HCC) model. Hep3B tumors were generated right flanks 14 NSG 7 NOD-SCID mice. The mice grouped as follows: A (acute, with n=9...
Purpose: Theaim of this peper was to retrospectively review our experience utilising protective fluid instillation techniques during percutaneous microwave ablation liver tumours determine if prevents non-target injuries and allows a more aggressive case selection. Materials methods: This institute board-approved, US Health Insurance Portability Accountability Act-compliant, retrospective study reviewed 151 malignant hepatic in 87 patients, comparing cases which performed with those where no...
The cellular introduction of short, interfering RNA leads to sequence-specific degradation homologous mRNA, a process termed interference (RNAi). Here, we report that recombinant adeno-associated virus 2 (rAAV-2) can be used transfer short hairpin (sh) expression cassettes genetically into human cells. HIV-1 replication was suppressed by >95% in H9 cells and primary lymphocytes expressed shRNA targeting the first exon viral transactivator protein tat compared control rAAV-2 integrated stably...
Percutaneous absolute ethanol injections and Nd: YAG laser ablations were performed bilaterally in canine prostates (N=13) using transrectal ultrasound guidance. Seventy-one percent (10/14) of the produced an intraglandular focus hemorrhagic necrosis. Associated morbidity included necrosis external prostatic sphincter mucosa urethra bladder. Ninety-two (11/12) foci thermal tissue damage, which had distinct margins transition between necrotic viable cells. The areas ablation well visualized...
A new polymeric ratiometric glucose sensor was synthesized and used for dynamically monitoring intracellular concentrations in HeLa cells.
Departments of Bacteriology and Immunology, Radiology, Surgery, Harvard Medical School Peter Bent Brigham Hospital, Boston, Massachusetts