A5101569890- Tribology and Wear Analysis
- Ion channel regulation and function
- High Entropy Alloys Studies
- Biocrusts and Microbial Ecology
- Metal and Thin Film Mechanics
- Neuroscience and Neuropharmacology Research
- Algal biology and biofuel production
- High-Temperature Coating Behaviors
- Lubricants and Their Additives
- Cardiac electrophysiology and arrhythmias
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Diamond and Carbon-based Materials Research
- Polymer Nanocomposites and Properties
- Epilepsy research and treatment
- Petroleum Processing and Analysis
- Aquatic Ecosystems and Phytoplankton Dynamics
- Electrohydrodynamics and Fluid Dynamics
- Nuclear Materials and Properties
- Mycorrhizal Fungi and Plant Interactions
- Botany and Geology in Latin America and Caribbean
- Enhanced Oil Recovery Techniques
- Photosynthetic Processes and Mechanisms
- Genetic diversity and population structure
- Advanced materials and composites
Chinese Academy of Sciences
2016-2025
Shanghai Institute of Materia Medica
2012-2025
Sichuan Agricultural University
2025
University of Chinese Academy of Sciences
2016-2024
Beijing National Laboratory for Molecular Sciences
2024
Xinjiang Medical University
2024
State Key Laboratory of Oncogene and Related Genes
2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Cancer Institute
2024
Understanding the nature of non-covalent interactions (NCIs) between asphaltene molecules is not only theoretically interesting but also important for practical application. We performed quantum chemical calculations to reveal configuration feature and intermolecular interaction characteristics dimers using three representative model compounds their derivatives. The frontier molecular orbitals electrostatic potential map asphaltenes were analyzed monomers. calculation binding energies...
The purpose of this work is to investigate the relationship between chemical structure GO materials and demulsification performance.
We previously reported that P-retigabine (P-RTG), a retigabine (RTG) analogue bearing propargyl group at the nitrogen atom in linker of RTG, displayed moderate anticonvulsant efficacy. Recently, our further efforts led to discovery HN37 (pynegabine), which demonstrated satisfactory chemical stability upon deleting ortho liable −NH2 and installing two adjacent methyl groups carbamate motif. exhibited enhanced activation potency toward neuronal Kv7 channels high vivo efficacy range...
Voltage-gated potassium (Kv) channels derive their voltage sensitivity from movement of gating charges in voltage-sensor domains (VSDs). The translocate through a physical pathway the VSD to open or close channel. Previous studies showed that charge pathways Shaker and Kv1.2-2.1 chimeric are occluded, forming structural basis for focused electric field transfer center. Here, we show voltage-gated KCNQ2 channel, activity reduction which causes epilepsy, can accommodate various small molecule...
Abstract Pancreatic cancer is one of the most malignant tumors with highest mortality rates, and it currently lacks effective drugs. Aptamer-drug conjugates (ApDC), as a form nucleic acid drug, show great potential in therapy. However, instability acid-based drugs vivo avascularity pancreatic dense stroma have limited their application. Fortunately, VNP20009, genetically modified strain Salmonella typhimurium , which has preference for anaerobic environments, but toxic specificity, can...
Despite ongoing research efforts aimed at understanding the structural response of steel fiber reinforced concrete (SFRC), there is very limited on failure characteristics and theoretical compression-bending capacity unreinforced (SFRC without rebars, USFRC). In this study, cube compression tests, notched beam full-scale segment tests are carried out to investigate flexural performance USFRC. The crack width–bending moment curves, load–deflection ultimate load USFRC segments obtained....
Functionalized carbon black (F-CB) nanoparticles were synthesized by covalently grafting the polyvinyl alcohol on (CB) surfaces and used as demulsifier to separate oil from emulsified oily wastewater. The bottle test showed that residual content in separated water was low ∼50 mg/L corresponding a demulsification efficiency of about 99.90% at an optimal condition within few minutes. It believed surface wettability could be tuned modifying with PVA molecules, which enables F-CB readily...
A dense exopolysaccharide (EPS) matrix is crucial for cyanobacterial survival in terrestrial xeric environments, which cyanobacteria undergo frequent expansion and shrinkage processes during environmental desiccation-rehydration cycles. However, it unclear how coordinate the structural dynamics of EPS upon to avoid potential mechanical stress while benefiting from matrix. In present study, we sought answer this question by investigating gene expression, protein dynamics, enzymatic...
The method of enhancing the photoluminescence (PL) nonconventional luminogens, especially room-temperature phosphorescence (RTP) by tableting, has been recognized, but underlying mechanism not elucidated. To clarify this, specific law between changing emission center and its should be studied precisely. Herein, a packing density-promoted (PDE) strategy is proposed using three solid states (film, powder, tablet) cellulose nanocrystals with well-defined crystal structure, in which their...
The voltage-gated KCNQ1 potassium channel is expressed in cardiac tissues, and coassembly of with an auxiliary KCNE1 subunit mediates a slowly activating current that accelerates the repolarization action potential cardiomyocytes. Mutations genes result reduction or loss activity cause prolongation during potential, thereby causing long QT syndrome (LQTs). Small molecule activators KCNQ1/KCNE1 are useful both for understanding mechanism complex developing therapeutics LQTs. In this study we...