A5067553207- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Advanced materials and composites
- Nuclear Materials and Properties
- Alzheimer's disease research and treatments
- Advanced ceramic materials synthesis
- Microbial Metabolic Engineering and Bioproduction
- Catalytic Processes in Materials Science
- Intermetallics and Advanced Alloy Properties
- Metabolism, Diabetes, and Cancer
- High-Temperature Coating Behaviors
- Diabetes Treatment and Management
- Antimicrobial Resistance in Staphylococcus
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Redox biology and oxidative stress
- Medicinal Plants and Neuroprotection
- Phosphodiesterase function and regulation
- Toxin Mechanisms and Immunotoxins
- Tryptophan and brain disorders
- Bacterial biofilms and quorum sensing
- Microbial metabolism and enzyme function
- Biochemical Acid Research Studies
East China University of Science and Technology
2017-2025
Shanghai Institute of Ceramics
2022-2025
Chinese Academy of Sciences
2013-2025
University of Chinese Academy of Sciences
2022-2025
Hainan University
2024
Western Regional Research Center
2024
University of California, Berkeley
2021
Shanghai Mental Health Center
2020
Shanghai Jiao Tong University
2020
University of Strathclyde
2018
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive. Here we demonstrated that SGLT2 inhibitor, Empagliflozin (EMPA), suppresses cardiomyocytes autosis (autophagic cell death) to confer cardioprotective effects. Using myocardial infarction (MI) mouse models and without mellitus, EMPA treatment significantly reduced infarct size, fibrosis, thereby leading improved cardiac...
Heart failure (HF) is a major global health threat, characterized by high morbidity and mortality. Targeting cardiac hypertrophy has been identified as potential therapy for HF, with current treatments showing limited efficacy. Our research aims to address this limitation exploring new structural classes of therapeutic agents. Starting from the natural product catalpol, we designed series novel catalpol analogs break through limitations analogs, improve anti-HF efficacy metabolic properties....
Through drug discovery strategies of repurposing and redeveloping existing drugs, a series novel tadalafil derivatives were rationally designed, synthesized, evaluated to seek dual-target AChE/PDE5 inhibitors as good candidate drugs for Alzheimer's disease (AD). Among these derivatives, 1p 1w exhibited excellent selective inhibitory activities improved blood-brain barrier (BBB) penetrability. Importantly, 1w·Cit (citrate 1w) could reverse the cognitive dysfunction scopolamine-induced AD mice...
Oxidation of methionine leads to the formation S and R diastereomers sulfoxide (MetO), which can be reversed by actions two structurally unrelated classes reductase (Msr), MsrA MsrB, respectively. Although MsrAs have long been demonstrated in numerous bacteria, their physiological biochemical functions remain largely unknown Actinomycetes. Here, we report that a Corynebacterium glutamicum A (CgMsrA) belongs 3-Cys family plays important roles oxidative stress resistance. Deletion msrA gene C....
NrdH redoxins are small protein disulfide oxidoreductases behaving like thioredoxins but sharing a high amino acid sequence similarity to glutaredoxins. Although supposed be another candidate in the antioxidant system, their physiological roles oxidative stress remain unclear. In this study, we confirmed that Corynebacterium glutamicum redoxin catalytically reduces disulfides class Ib ribonucleotide reductases (RNR), insulin and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB), by exclusively...
Previous studies have identified a putative mycothiol peroxidase (MPx) in Corynebacterium glutamicum that shared high sequence similarity to sulfur-containing Gpx (glutathione peroxidase; CysGPx). In the present study, we investigated MPx function by examining its potential activity using different proton donors. The degrades hydrogen peroxide and alkyl hydroperoxides presence of either thioredoxin/Trx reductase (Trx/TrxR) or mycoredoxin 1/mycothione reductase/mycothiol (Mrx1/Mtr/MSH)...
Abstract Drug discovery and development is a time-consuming costly process. Therefore, drug repositioning has become an effective approach to address the issues by identifying new therapeutic or pharmacological actions for existing drugs. The drug’s anatomical chemical (ATC) code hierarchical classification system categorized as five levels according organs systems that drugs act pharmacology, properties of 2nd-, 3rd- 4th-level ATC codes reserved information With hypothesis with similar...
Conducting vibration monitoring during bridge construction is of significance for ensuring the safety personnel and property achieving risk management controlling. However, current faces numerous challenges, including a large number measurement points, significant frequency differences, vast structural scales, lack fixed reference difficulties in temporary deployment. This paper proposes method based on computer vision. The utilizes high-definition cameras to capture dynamic images bridges...
Abstract The research on the oxidant behavior of high‐entropy diborides (HEBs) is essential to facilitate their application in extreme environments. In this work, (Ti 1/3 Zr Hf )B 2 , Ta 1/4 and 1/5 15 W were used for comparative study reflect effects different elements oxidation resistance, ZrB was as a control. After oxidization at 1400°C 30 min, oxide layers thicknesses 380, 290, 250, 190, 200 µm, respectively. results showed that had best antioxidant performance due formation special...
Depression is one of the most frequent psychiatric complications Alzheimer's disease (AD), affecting up to 50% patients. A novel series hybrid molecules were designed and synthesized by combining pharmacophoric features vilazodone tacrine as potential multitarget-directed ligands for treatment AD with depression. In vitro biological assays conducted evaluate compounds; among 30 hybrids, compound 1e showed relatively balanced profiles between acetylcholinesterase inhibition (IC50 = 3.319 ±...
Multifunctional agents aiming at cholinesterases (ChEs) and monoamine oxidases (MAOs) are promising therapy for Alzheimer's disease (AD). Herein, a series of novel propargylamine-modified pyrimidinylthiourea derivatives (1–4) were designed synthesized as dual inhibitors ChEs MAOs with other functions against AD. Most these inhibited IC50 values in the micro- or nanomolar ranges. Compound 1c displayed functional profile targeting AChE (IC50 = 0.032 ± 0.007 μM) MAO-B 2.117 0.061 μM), along...
Drug repurposing is an efficient strategy for new drug discovery. Our latest study found that nitazoxanide (NTZ), approved anti-parasite drug, was autophagy activator and could alleviate the symptom of Alzheimer's disease (AD). In order to further improve efficacy discover chemical entities, a series NTZ-based derivatives were designed, synthesized, evaluated as against AD. All compounds screened by inhibition phosphorylation p70S6K, which direct substrate mammalian target rapamycin (mTOR)...
Fructose 1,6-bisphosphatase (FBPase) has attracted substantial interest as a target associated with cancer and type 2 diabetes. Herein, we found that disulfiram its derivatives can potently inhibit FBPase by covalently binding to new C128 allosteric site distinct from the original in APO FBPase. Further identification of inhibition mechanism reveals covalent fragment 214 will result movement dissociation helix H4 (123–128), which turn allows S123 more easily form hydrogen bonds K71 D74 H3...