A5031656017- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple Myeloma Research and Treatments
- Vasculitis and related conditions
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Platelet Disorders and Treatments
- Trace Elements in Health
- Pregnancy and Medication Impact
- Parathyroid Disorders and Treatments
- Mercury impact and mitigation studies
- Renal and related cancers
- IgG4-Related and Inflammatory Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal and Vascular Pathologies
- COVID-19 Clinical Research Studies
- Renal cell carcinoma treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
Peking University First Hospital
2016-2025
Peking University
2016-2025
Ministry of Education of the People's Republic of China
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Zhongshan Hospital of Xiamen University
2024
National Health and Family Planning Commission
2017-2022
King University
2012-2021
Bridge University
2014-2016
Second Hospital of Yichang
2015
Metabolism and Renal Physiology
2010
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European population, but it is unknown whether a similar association exists Chinese population high-risk promote development of anti-PLA2R antibodies. Here, we genotyped 2132 individuals, including 1112 patients IMN 1020 healthy controls, for three single nucleotide polymorphisms (SNPs) within PLA2R1 SNPs HLA genes. We also selected 71...
Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no model targeting among general hospitalized patients in developing countries has been published. Here we show simple, real-time, interpretable developed from large tertiary hospital China, which validated across five independent, geographically distinct, different tiered hospitals. The containing 20 readily available variables demonstrates consistent, high levels predictive...
BackgroundThe association of kidney disease with Castleman (CD) is uncommon. To date, most studies have been based on single-case reports. Here, we describe renal involvement in CD a large Chinese cohort.
Rituximab had been shown to be effective in inducing remission of nephrotic syndrome patients with idiopathic membranous nephropathy (iMN). This study applied rituximab therapy for 36 non-responsive iMN investigate its effects and safety.Thirty-six who were prior immunosuppression enrolled. was used B-cell depletion patients, a goal <5 B cells/mm3 the circulation. After completing study, monitored median 12.0 months [interquartile range (IQR) 9.0-19.3].Fifteen (41.7%) achieved partial (n =...
Long-term exposure of mercury may induce glomerulonephritis. Clinical and pathological features mercury-associated glomerulonephritis are not fully clear. This study retrospectively analyzed 35 cases in a single Chinese center.Thirty-five patients were enrolled. data on diagnosis during follow-up collected. Plasma anti-phospholipase A2 receptor (PLA2R) antibody, glomerular PLA2R IgG subclasses deposition detected the with membranous nephropathy (MN).Mercury was caused by skin lighting cream...
Patients with monoclonal gammopathy and concomitant kidney diseases are frequently found in clinical practice. Some of them diagnosed renal significance (MGRS) due to the presence Ig-related injuries. This study aimed investigate histopathologic spectrum characteristics associated MGRS a large cohort patients biopsy-proven from single Chinese nephrology referral center.Patients who presented (monoclonal spike on serum and/or urine immunofixation tests) underwent biopsy Peking University...
The elderly population has significantly increased in China. However, data regarding renal histopathology this is lacking. present study retrospectively analyzed disease spectrum of 430 patients who had received biopsy at Peking University First Hospital between January 2003 and December 2012. Among 6049 receiving biopsies during the same period, (7.10%) were (≥65 years). ratio male (263 patients) to female (167 was 1.57:1, with an age 70.29 ± 3.99 (range 65–82) years time biopsy. most...
The aim of this study was to evaluate the efficacy plasmapheresis in patients with lupus nephritis-combined thrombotic microangiopathy (TMA) a Chinese cohort.Clinical and therapeutic data TMA were collected retrospectively. A comparison between those without performed.Seventy renal biopsy-proven nephritis treated conventional combined corticosteroid immunosuppressive agents as induction therapy, 9 70 received additional plasmapheresis. group presented more severe SLE activity indices,...
Q fever, a zoonosis caused by the intracellular bacterium Coxiella burnetii, is significant infectious disease that affects both humans and animals[1]. It characterized wide array of clinical presentations, which can range from asymptomatic to severe life-threatening conditions. One most serious complications fever development glomerulonephritis (GN), progress chronic kidney if left untreated [2]. The epidemiology in China, as many other regions, has been obscured lack comprehensive data,...
<b><i>Background:</i></b> Crescentic IgA nephropathy (CreIgAN) has a poor prognosis despite aggressive immunosuppressive therapy. The efficacy of plasma exchange (PE) in CreIgAN is not well defined. <b><i>Methods:</i></b> Twelve patients with severe who received PE as addition to routine therapy, followed for more than 6 months, were involved. matched historical controls therapy alone selected by propensity score matching. Renal survival,...
Background: Leukocyte chemotactic factor 2 (ALECT2) amyloidosis is one of the recently described types amyloidosis. In this study, we reported first large case series renal ALECT2 in Chinese patients.Methods: We studied prevalence, clinical characteristics, pathology, outcome and genetic features among seven patients diagnosed with at Peking University First Hospital China from 2000 to 2018.Results: Seven were amyloidosis, representing 1.9% biopsy-proven cases. The mean age diagnosis was 68...
Subcutaneous daratumumab plus bortezomib/cyclophosphamide/dexamethasone (VCd; D-VCd) improved outcomes versus VCd for patients with newly diagnosed immunoglobulin light-chain (AL) amyloidosis in the phase 3 ANDROMEDA study. We report a subgroup analysis of Asian (Japan; Korea; China) from ANDROMEDA. Among 388 randomized patients, 60 were (D-VCd, n = 29; VCd, 31). At median follow-up 11.4 months, overall hematologic complete response rate was higher D-VCd (58.6% vs. 9.7%; odds ratio, 13.2;...
In Brief Background and Aims: Invasive pulmonary aspergillosis (IPA) has been reported as a severe opportunistic infection in immunocompromised patients without neutropenia or cancer. Patients with antineutrophil cytoplasmic antibody associated vasculitis (AAV) immunosuppressive treatment are susceptible to IPA, but only few cases were the literature. We retrospectively analyze clinical characteristics of our IPA AAV. Methods: Hospitalized AAV who developed selected. Their data reviewed...
Background: Rituximab has become one of the first-line therapies for treatment moderate and high-risk primary membranous nephropathy (pMN). We retrospectively reviewed 95 patients with pMN who received rituximab therapy focused on therapeutic effects safety this in a Chinese cohort. Methods: Ninety-five consecutive diagnosed by kidney biopsy were followed up &gt;6 months. Four weekly doses (375 mg/m 2 ) was adopted as initial administration. Repeated single infusions administrated to...
Cases of membranous nephropathy (MN) with crescent formation, in the absence lupus, hepatitis B virus infection, anti-glomerular basement membrane (GBM) nephritis, or antineutrophil cytoplasmic antibody (ANCA), are on record. Clinical presentation and treatment outcomes these patients unclear. All biopsy-proven MN diagnosed between years 2008 2014 followed up were enrolled retrospectively. Patients ANCA, anti-GBM antibodies, malignance excluded. features compared without crescent. Out 401...
ABSTRACT Objectives To analysis the pathological spectrum and prognosis of monoclonal gammopathy renal significance (MGRS) patients. Methods Patients with biopsy‐proven MGRS from 1999 to 2017 in Peking University First Hospital were included, clinical data, pathology type, treatment collected. Results One hundred eighty‐seven patients enrolled, accounting for 0.7% biopsies. Seventy‐seven per cent amyloidosis. Eighteen (9.6%) immunoglobulin deposition disease. Others included 10 (5.3%)...
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an acute, rare potentially fatal drug reaction.To date, limited studies have reported secondary Pneumocystis jirovecii pneumonia (PJP) infection during the treatment of DRESS syndrome.A 53-year-old man was admitted to hospital due a persistent fever lasting for 5 days.He had medical history hypertension, psoriasis, urticaria, recently been treated carbamazepine nerve spasm two weeks ago.After admission, patient...
Background: Light-chain proximal tubulopathy (LCPT) is a rare disease characterized by the accumulation of monoclonal light chains within tubular cells. This study aimed to investigate clinical characteristics LCPT from single Chinese nephrology referral center.Methods: Patients with kidney biopsy-proven isolated between 2016 and 2022 at Peking University First Hospital were retrospectively included. Clinical data, pathological type, treatment, prognosis analyzed.Results: Nineteen patients...