A5078761190- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Usability and User Interface Design
- Biosimilars and Bioanalytical Methods
- Immunotherapy and Immune Responses
- Personal Information Management and User Behavior
- Multimedia Communication and Technology
- Multiple Myeloma Research and Treatments
- Systemic Lupus Erythematosus Research
- Advanced Software Engineering Methodologies
- Immune Response and Inflammation
- Software Engineering Techniques and Practices
- Context-Aware Activity Recognition Systems
- Software Engineering Research
- Service-Oriented Architecture and Web Services
- Hematopoietic Stem Cell Transplantation
- Cell death mechanisms and regulation
- Rheumatoid Arthritis Research and Therapies
- Glycosylation and Glycoproteins Research
- Video Analysis and Summarization
- Web Data Mining and Analysis
- Chronic Lymphocytic Leukemia Research
Latham & Watkins (United States)
2023
Codex Biosolutions (United States)
2019-2021
FX Palo Alto Laboratory
2002-2008
Human Genome Sciences (United States)
1998-2007
Fuji Xerox (Japan)
2004
Xerox (United States)
2001
Palo Alto Research Center
2001
University of California, Irvine
1996-2000
National Institutes of Health
1990-1998
National Cancer Institute
1989-1996
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member the human TNF family, BLyS (B lymphocyte stimulator), was identified induced B cell proliferation immunoglobulin secretion. expression on monocytes could be up-regulated by interferon-γ. Soluble functioned as a potent growth in costimulation assays. Administration recombinant to mice disrupted splenic T zones resulted elevated serum...
The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr -/- ) mouse line was constructed by homologous recombination in embryonic stem cells. Almost half the mice died shortly after birth, whereas survivors reached maturity were fertile. Ahr showed decreased accumulation lymphocytes spleen lymph nodes, but not thymus. livers reduced size 50 percent bile duct fibrosis. also...
To determine whether serum levels of B lymphocyte stimulator (BLyS) are elevated in patients with systemic immune-based rheumatic diseases and correlate Ig and/or autoantibody titers.Sera from 185 various (95 lupus erythematosus [SLE], 67 rheumatoid arthritis [RA], 23 other diagnoses) were assayed for BLyS Ig. In 7 who required arthrocentesis a swollen knee, coincident synovial fluid samples BLyS. Medical charts retrospectively reviewed titers proteinuria within 1-month period before or...
Abstract Objective To assess the overexpression of B lymphocyte stimulator (BLyS) over time in patients with systemic lupus erythematosus (SLE). Methods Sixty‐eight SLE were followed up longitudinally for a median 369 days. At each physician encounter, disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index, and blood collected determination serum BLyS level, messenger RNA (mRNA) cell surface expression. Twenty normal control subjects underwent similar laboratory...
To identify and characterize a fully human antibody directed against B lymphocyte stimulator (BLyS), tumor necrosis factor-related cytokine that plays critical role in the regulation of cell maturation development. Elevated levels BLyS have been implicated pathogenesis autoimmune diseases.A phage display library was screened for antibodies BLyS. A monoclonal antibody, LymphoStat-B, specific obtained from screening subsequent affinity optimization mutagenesis. The tested inhibition vitro an...
B lymphocyte stimulator (BLyS) is a newly identified monocyte-specific TNF family cytokine. It has been implicated in the development of autoimmunity, and functions as potent costimulator with antiimmunoglobulin M cell proliferation vitro. Here we demonstrate that BLyS prominently enhances humoral responses to both T cell-independent cell-dependent antigens, primarily by attenuation apoptosis evidenced prolonged survival antigen-activated cells vivo acts on primary splenic autonomously,...
Abstract These studies characterize BLyS responsiveness and receptor expression among transitional mature peripheral B cells. The results show a maturation-associated increase in binding capacity that reflects differential patterns of the three receptors. Accordingly, administration enlarges only late (MB) cell compartments. Furthermore, bromodeoxyuridine labeling cycle analyses these effects are mediated through enhanced proportional survival cells traversing T2, T3, MB stages, rather than...
Abstract Objective To assess the effects of B lymphocyte depletion on serum stimulator (BLyS; trademark Human Genome Sciences, Rockville, MD) levels in patients with rheumatoid arthritis (RA), and to relationship BLyS peripheral blood cell depletion, autoantibodies antimicrobial antibodies, return cells, clinical relapse. Methods Fifteen active RA underwent rituximab‐based therapy (BCDT). Disease activity was assessed clinically, CD19+ counts were determined by flow cytometry, BLyS, IgM,...
Abstract BLyS and APRIL are two members of the TNF superfamily that secreted by activated myeloid cells have costimulatory activity on B cells. share receptors, TACI BCMA, whereas a third receptor, BAFF-R, specifically binds BLyS. Both been described as homotrimeric molecules, feature common to superfamily. In this study, we show can form active heterotrimeric molecules when coexpressed circulating heterotrimers present in serum samples from patients with systemic immune-based rheumatic...
Interleukin (IL) 6 has been suggested to be the major cytokine responsible for proliferation of neoplastic plasma cells in both human myeloma and mouse plasmacytoma. Much evidence supporting this suggestion is derived from vitro studies which survival or some cell tumors found IL-6 dependent. However, it remains unclear whether dependency consequence vivo selective pressures that preferentially expand IL-6-responsive tumor cells, reflects a critical role neoplasia. To address question, we...
Abstract Objective To determine whether synovial fluid (SF) levels and cell‐surface expression of B lymphocyte stimulator (BLyS) protein SF APRIL are elevated in patients with inflammatory arthritis (IA). Methods Same‐day blood samples from 89 103 knee effusions (81 knees IA 22 noninflammatory [NIA]) were evaluated for BLyS by enzyme‐linked immunosorbent assay. Blood mononuclear cells double‐stained surface CD14 (monocyte marker) analyzed flow cytometry. Complete cell counts nucleated...
Abstract Considerable evidence points to a role for B lymphocyte stimulator (BLyS) overproduction in murine and human systemic lupus erythematosus (SLE). Nevertheless, the correlation between circulating levels of BLyS protein disease activity SLE is modest at best. This may be due an inadequacy former reflect endogenous faithfully, that steady-state are affected not just by production rates but also peripheral utilization excretion. Increased mRNA better increased vivo production, therefore...
ABSTRACT Herein, we report that Autographa californica nucleopolyhedrovirus, a member of the Baculoviridae family, is capable stimulating antiviral activity in mammalian cells. Baculoviruses are not pathogenic to Nevertheless, live baculovirus shown here induce interferons (IFN) from murine and human cell lines induces vivo protection mice encephalomyocarditis virus infection. Monoclonal antibodies specific for envelope gp67 neutralize baculovirus-dependent IFN production. Moreover, UV...
This article describes how the changing information about an individual's location, environment, and social situation can be used to initiate facilitate people's interactions with one another, individually in groups. Context-aware communication is contrasted other forms of context-aware computing, we characterize applications terms design decisions along two dimensions: extent autonomy context sensing action. A number from research literature are presented five application categories....
IL-6 (formerly PCTGF, HP-1, BSF-2, HGF, IFN-beta 2, 26 kDa) is a recently defined lymphokine demonstrating activity on multiple cell types, including hepatocytes, thymocytes, T cells, plasmacytomas, and B cells. The biologic effects of lymphocytes, particularly suggest this factor may be involved in the regulation normal immune responses. Accordingly, we have investigated role Ag-specific responses cells from both naive Ag-primed mice. When splenic were used as source help, (primary)...
Despite the clinical success of anti-tumor necrosis factor (TNF) therapies in treatment inflammatory conditions such as rheumatoid arthritis, Crohn disease and psoriasis, full control diseases only occurs a subset patients there is need for new therapeutics with improved efficacy against broader patient populations. One possible approach to combine biological therapeutics, but both cost potential additional toxicities needs be considered. In addition various mediators immune pathways,...
The recognition that few human diseases are thoroughly addressed by mono-specific, monoclonal antibodies (mAbs) continues to drive the development of antibody therapeutics with additional specificities and enhanced activity. Historically, efforts engineer antigen into molecules have relied predominantly on reformatting immunoglobulin domains. In this report we describe a series fully functional mAbs which been imparted through recombinant fusion relatively short polypeptides sequences....