A5080003606- Neural and Behavioral Psychology Studies
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Genetic Neurodegenerative Diseases
- Memory Processes and Influences
- Action Observation and Synchronization
- Psychoanalysis and Psychopathology Research
- Health, Medicine and Society
- Trace Elements in Health
- Neurobiology of Language and Bilingualism
- Neurology and Historical Studies
- Aluminum toxicity and tolerance in plants and animals
- Identity, Memory, and Therapy
- Heavy Metal Exposure and Toxicity
- Traumatic Brain Injury Research
- Neurological disorders and treatments
- Spatial Neglect and Hemispheric Dysfunction
- Pharmacological Effects and Toxicity Studies
- Psychosomatic Disorders and Their Treatments
- Analytical Chemistry and Chromatography
- Child and Animal Learning Development
- Face Recognition and Perception
- Epilepsy research and treatment
- Attention Deficit Hyperactivity Disorder
- Stroke Rehabilitation and Recovery
Centre Hospitalier Universitaire d'Angers
2016-2025
Laboratoire de Psychologie des Pays de la Loire
2016-2025
Nantes Université
2013-2025
Université d'Angers
2016-2025
Centre Hospitalier de Tourcoing
2021
Philips (France)
2005-2020
Université Nantes Angers Le Mans
2012-2019
Imagerie Médicale et Radiothérapie Drôme Ardèche
2019
University of Geneva
2009-2015
Swiss National Science Foundation
2015
Oxaliplatin, classical [5-fluorouracil (5-FU)] and non-classical (AG337) thymidylate synthase inhibitors have shown promising activity in the treatment of cancer. This study investigates cytotoxic effects oxaliplatin combination with 5-FU AG337 cultured human colon (HT29, CaCo2), breast (MCF-7, MDA-MB-231) ovarian (2008) cancer cell lines, their derived counterparts selected for resistance to (HT29-5-FU), doxorubicin (MCF-7mdr) or cisplatin (2008C13). Therapeutic experiments were conducted...
The association between low serum 25-hydroxyvitamin D [25(OH)D] concentration and cognitive decline has been investigated by only a few studies, with mixed results. objective of this cross-sectional population-based study was to examine the 25(OH)D deficiency impairment while taking confounders into account.The subjects, 752 women aged > or =75 years from Epidémiologie de l'Ostéoporose (EPIDOS) cohort, were divided 2 groups according concentrations (either deficient, <10 ng/mL, nondeficient,...
Studies have shown that the Four Seasons music may enhance autobiographical performance of Alzheimer's disease (AD) patients. We used a repeated measures design in which recall 12 mild AD patients was assessed using free narrative method under three conditions: (a) "Silence," (b) after being exposed to opus Seasons, and (c) their own Chosen music. Recall higher than conditions, both were Silence. Autobiographical improvement also characterized by an enhancement positive emotional words. The...
Alzheimer's disease (AD) causes impairments affecting instrumental activities of daily living (IADL). Transdisciplinary research in neuropsychology and virtual reality has fostered the development ecologically valid tools for assessment IADL, using simulations real life activities. Few studies have examined benefits this approach AD patients. Our aim was to examine utility a non-immersive coffee task (NI-VCT) IADL these We focus on results obtained from group 24 patients designed assess...
Impairments in performing activities of daily living occur early the course Alzheimer's disease (AD). There is a great need to develop non-pharmacological therapeutic interventions likely reduce dependency everyday AD patients. This study investigated whether it was possible increase autonomy these patients cooking using based on errorless learning, vanishing-cue, and virtual reality techniques. We recruited 79-year-old woman who met NINCDS-ADRDA criteria for probable AD. She trained four...
Background: Behavioural changes are often reported after a severe traumatic brain injury (TBI). These usually greater burden for relatives than physical or cognitive impairments. This study investigated social cognition in TBI patients using two theory of mind (TOM) tasks.Method: The performances 17 with and matched controls were compared on tasks designed to investigate understanding other people's mental states: 'Reading the Mind Eyes' test (RME) 'Character Intention Task' (CIT). also...
To evaluate if three-dimensional echocardiography (3-DE) is as accurate and reproducible cine magnetic resonance imaging (cMR) in estimating left ventricular (LV) parameters patients with without wall motion abnormalities (WMA).83 (33 WMA) underwent 3-DE cMR. datasets were analysed using a semi-automatic contour detection algorithm. The accuracy of was tested against cMR the two groups patients. All measurements made twice by different observers.LV mass similar to that obtained (149 (SD 42)...
Abstract Alcohol-dependent individuals usually favor instant gratification of alcohol use and ignore its long-term negative consequences, reflecting impaired decision-making. According to the somatic marker hypothesis, decision-making abilities are subtended by an extended brain network. As chronic consumption is known be associated with shrinkage in this network, present study investigated relationships between impairments alcohol-dependent early abstinence using voxel-based morphometry....
We use ultraviolet data, acquired with a photodiode-array detector coupled to reversed-phase liquid-chromatographic system, identify unknown drugs in plasma samples of acutely poisoned patients. Both retention time and spectra the peaks obtained microbore Hypersil ODS column under gradient elution are compared library approximately 350 compounds. present our three-year experience this which identifies less than 1 h, high degree confidence.
Alcoholism affects various cognitive processes, including components of memory. Metamemory, though particular interest for patient treatment, has not yet been extensively investigated. A feeling-of-knowing (FOK) measure metamemory was administered to 28 alcoholic patients and healthy controls during an episodic memory task the learning 20 pairs items, followed by a 20-minute delayed recall recognition task. Prior recognition, participants rated their ability recognize each nonrecalled word...
The main aim of this study was to investigate the effects Huntington's disease (HD) on cognitive and affective Theory Mind (ToM) abilities. relation ToM performance executive functions also examined. Eighteen HD patients, early in course disease, 18 healthy volunteers matched for age educational levels, were given two tasks: a nonverbal task assessing attribution intentions others revised version 'Reading Eyes' test, which is an understanding other people's mental states from their eyes....
Background Patients' personal investment and readiness to change have proved be a prerequisite for the successful treatment of alcohol addiction. The aim this study was determine contribution cognitive functions motivation process abandon maladjusted behavior in favor healthier lifestyle. Methods An adapted version “readiness change” questionnaire completed by 31 alcohol‐dependent patients after detoxification at entry. This tool is designed assess 3 main stages regarding consumption:...
Although Theory of Mind (ToM) is thought to be impaired in Alzheimer's disease (AD), it remains unclear whether this impairment linked the level task complexity, heterogeneity studied patients, or implication executive dysfunctions. To elucidate point, 42 AD divided into two subgroups [moderate (mAD) patients (n = 19) and early (eAD) 23)], 23 matched healthy older subjects (HO) were enrolled. All participants given (1) a false-belief (cognitive ToM), (2) revised version "Reading Eyes" test...
Traumatic brain injury (TBI) causes impairments affecting instrumental activities of daily living (IADL). However, few studies have considered virtual reality as an ecologically valid tool for the assessment IADL in patients who sustained a TBI. The main objective present study was to examine use Nonimmersive Virtual Coffee Task (NI-VCT) with We analyzed performance 19 adults suffering from TBI and healthy controls (HCs) real tasks making coffee machine, well global IQ executive functions....