A5057116885- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Nutrition and Health in Aging
- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Diabetes Treatment and Management
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Body Composition Measurement Techniques
- Thyroid and Parathyroid Surgery
- Bacterial Identification and Susceptibility Testing
- Growth Hormone and Insulin-like Growth Factors
- Intensive Care Unit Cognitive Disorders
Kantonsspital Aarau
2016-2025
Brigham and Women's Hospital
2021-2025
University of Basel
2015-2025
Harvard University
2021-2025
University Hospital of Basel
2018-2023
Diabetes Australia
2021-2023
RELX Group (Netherlands)
2023
RELX Group (United States)
2023
General Department of Preventive Medicine
2016-2019
Hirslanden Klinik Aarau
2016
Abstract Introduction Early risk stratification in the emergency department (ED) is vital to reduce time effective treatment high-risk patients and improve patient flow. Yet, there a lack of investigations evaluating incremental usefulness multiple biomarkers measured upon admission from distinct biological pathways for predicting fatal outcome high initial urgency unselected ED multicenter multinational setting. Method We included consecutive, adult, medical seeking care into this...
Neutrophil extracellular traps (NETs) are a hallmark of the immune response in inflammatory diseases. However, role NETs community-acquired pneumonia (CAP) is unknown. This study aims to characterise impact on clinical outcomes pneumonia.This secondary analysis randomised controlled, multicentre trial. Patients with CAP were randomly assigned either 50 mg prednisone or placebo for 7 days. The primary end-point was time stability; main end-points length hospital stay and mortality.In total,...
There is a lack of validated tools to assess potential disease progression and hospitalisation decisions in patients presenting the emergency department (ED) with suspected infection. This study aimed identify suitable blood biomarkers (MR-proADM, PCT, lactate CRP) or clinical scores (SIRS, SOFA, qSOFA, NEWS CRB-65) fulfil this unmet need. An observational derivation patient cohort by an independent secondary analysis across nine EDs. Logistic Cox regression, area under receiver operating...
<h3>Importance</h3> Malnutrition affects a considerable proportion of patients in the hospital and is associated with adverse clinical outcomes. Recent trials found survival benefit among receiving nutritional support. <h3>Objective</h3> To investigate whether there an association support in-hospital mortality routine practice. <h3>Design, Setting, Participants</h3> This cohort study was conducted from April 2013 to December 2018 population Swiss administrative claims data. From 114 264...
<b><i>Background and Aims:</i></b> Malnutrition is associated with poor clinical outcomes. Whether there a causal relationship or it merely mirrors severe patient condition remains unclear. We examined the association of malnutrition biomarkers characteristic different pathophysiological states to better understand underlying etiological mechanisms. <b><i>Methods:</i></b> prospectively followed consecutive adult medical inpatients....
Objectives Recently, the Hospital Frailty Risk Score based on a derivation and validation study in UK has been proposed as low-cost, systematic screening tool to identify older, frail patients who are at greater risk of adverse outcomes for whom frailty-attuned approach might be useful. We aimed validate this an independent cohort Switzerland. Design Secondary analysis prospective, observational (TRIAGE study). Setting One 600-bed tertiary care hospital Aarau, Participants Consecutive...
Significance Statement Treatment options for the syndrome of inappropriate antidiuresis (SIAD), predominant cause hyponatremia, are inadequate. The authors studied effects sodium glucose cotransporter 2 inhibitor empagliflozin, which promotes osmotic diuresis via urinary excretion, in a randomized trial 87 hospitalized patients with SIAD-induced hyponatremia who were also treated standard fluid restriction. Patients received 4 days empagliflozin had significantly larger increase plasma...
To evaluate the comparative cardiovascular effectiveness and safety of sodium-glucose cotransporter 2 inhibitors (SGLT-2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), dipeptidyl peptidase 4 (DPP-4is) in older adults with type diabetes (T2D) across different frailty strata.
Abstract Whether or not antibiotic stewardship protocols based on procalcitonin levels results in cost savings remains unclear. Herein, our objective was to assess the economic impact of adopting testing among patients with suspected acute respiratory tract infection (ARI) from perspective a typical US integrated delivery network (IDN) 1,000,000 member catchment area enrollment. To conduct an evaluation versus usual care we built cost-impact model patient-level meta-analysis data randomized...
Only a small proportion of blood cultures routinely performed in emergency department (ED) patients is positive. Multiple clinical scores and biomarkers have previously been examined for their ability to predict bacteremia. Conclusive validation these essential. This observational cohort study included with suspected infection who had culture sampling at ED admission. We assessed 5 admission concentrations procalcitonin (PCT), C-reactive protein (CRP), lymphocyte white cell counts, the...
To investigate the accuracy of National Early Warning Score (NEWS) to predict mortality and adverse clinical outcomes for patients with community-acquired pneumonia (CAP) compared standard risk scores such as severity index (PSI) CURB-65.Secondary analysis included in a previous randomised-controlled trial median follow-up 6.1 years.Patients CAP on admission emergency departments (ED) 6 tertiary care hospitals Switzerland.A total 925 confirmed were included. NEWS, PSI CURB-65 calculated ED...
AIMS OF THE STUDY To describe admission characteristics, risk factors and outcomes of patients with coronavirus disease 2019 (COVID-19) hospitalised in a tertiary care hospital Switzerland during the early phase pandemic. METHODS This retrospective cohort study included adult severe acute respiratory syndrome 2 (SARS-CoV-2) infection confirmed by polymerase chain reaction (PCR) testing at cantonal Aarau (Switzerland) between 26 February 2020 30 April 2020. Our primary endpoint was COVID-19...
A higher risk for severe clinical courses of coronavirus disease 2019 (COVID-19) has been linked to deficiencies several micronutrients. We therefore studied the prevalence eight different micronutrients in a cohort hospitalized COVID-19-patients.
Abstract Context Metabolic dysfunction–associated fatty liver disease (MAFLD) is highly prevalent among patients with type 2 diabetes mellitus (T2DM); however, there still no approved pharmacological treatment. Sodium-glucose cotransporter (SGLT-2) inhibitors have been suggested to beneficially modify liver-related outcomes in diabetes. Objective We aimed investigate the effects of SGLT-2 inhibitor canagliflozin on advanced T2DM and high cardiovascular risk. Methods performed a secondary...
Abstract Objective Prediction of long‐term outcomes in patients with community‐acquired pneumonia ( CAP ) is incompletely understood. We investigated the value clinical risk scores [pneumonia severity index PSI and CURB ‐65] (Confusion, Urea, Respiratory rate, Blood Pressure, Age >65 years) blood biomarkers different physiopathological pathways predicting survival a well‐characterized cohort enrolled an antibiotic stewardship trial. Design, setting subjects Patients admitted to six...