A5041253589- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Heart Failure Treatment and Management
- Health and Lifestyle Studies
- Bone health and treatments
- Diabetes Management and Education
- Bone and Joint Diseases
- Healthcare Systems and Practices
- Vitamin D Research Studies
- Dialysis and Renal Disease Management
- Diabetes and associated disorders
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Pituitary Gland Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Aortic aneurysm repair treatments
- Medical Imaging and Pathology Studies
- Diabetes Management and Research
- Palliative Care and End-of-Life Issues
- Advances in Oncology and Radiotherapy
Kantonsspital St. Gallen
2015-2022
Endokrinologikum
2015
<h3>Importance</h3> Inflammation is a key driver of malnutrition during illness and often accompanied by metabolic effects, including insulin resistance reduction appetite. However, it still remains unclear if inflammation influences the response to nutritional support among patients with disease-related malnutrition. <h3>Objective</h3> To examine whether patients' baseline inflammatory status associated effect on 30-day mortality. <h3>Design, Setting, Participants</h3> This secondary...
<p class="abstract"><strong>Background:</strong> Malnutrition is highly prevalent and strongly associated with clincial outcomes of medical inpatients. Still, the benefit nutritional treatment to prevent adverse in inpatients at risk for malnutrition remains unproven. We describe trial methods largest yet including rationale key design decisions regarding strategy, eligibility criteria, choice control arm, endpoints.</p><p...
BackgroundAmong medical inpatients at risk of malnutrition, the use individualized nutritional support during hospital stay was found to reduce complications and improve mortality short-term. We evaluated clinical outcomes 6-months follow-up.MethodsWe randomly assigned 2028 patients receive protocol-guided reach protein energy goals (intervention group) or food as usual (control stay. The intervention discontinued discharge further based on discretion treating team. had complete follow-up...
Abstract The impact of vitamin D deficiency on the recovery patients with malnutrition remains undefined. Our aim was to study prevalence in a well-characterized cohort and its association outcomes. Within this secondary analysis randomized controlled trial, we examined adverse clinical outcomes over follow-up 180 days hospitalized at risk for malnutrition. We measured 25-hydroxyvitamin levels upon admission defined Vitamin when were <50nmol/l. primary endpoint 180-day mortality. our 828...
BackgroundIn polymorbid patients with bronchopulmonary infection, malnutrition is an independent risk factor for mortality. There a lack of interventional data investigating whether providing nutritional support during the hospital stay in at presenting lower respiratory tract infection lowers mortality.MethodsFor this secondary analysis randomized clinical trial (EFFORT), we analyzed subgroup confirmed from initial cohort 2028 patients. Patients (Nutritional Risk Screening [NRS] score ≥3...
Pheochromocytoma (PHEO) and paraganglioma (PGL) are catecholamine-producing neuroendocrine tumors that arise respectively inside or outside the adrenal medulla. Several reports have shown glucocorticoids (GC) play an important regulatory role on genes encoding main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine β-hydroxylase (DBH) phenylethanolamine N-methyltransferase (PNMT). To assess influence of tumor location CAT metabolism, 66 tissue samples...
Neuropeptide Y (NPY1-36) is a vasoconstrictor peptide co-secreted with catecholamines by sympathetic nerves, the adrenal medulla, and neoplasms such as pheochromocytomas paragangliomas (PPGLs). It produced intracellular cleavage of proNPY metabolized into multiple fragments distinct biological activities. NPY immunoassays for PPGL have diagnostic sensitivity ranging from 33 to 100%, depending on antibody used. We validated multiplex micro-UHPLC-MS/MS assay specific sensitive quantification...
Abstract Despite the current debate on best therapeutic approach, i.e. symptomatic vs intensive strategy, one zoledronate (Zol) infusion is effective in most patients with Paget’s disease of bone (PDB), whereas few need retreatment, whose predictors are not well established. We aimed to evaluate long-term efficacy Zol therapy and retreatment PDB. Pagetic complications, clinical biochemical response together frequency were retrospectively assessed forty-seven PDB (age, mean ± SD: 72.5 8.9...
Les épisodes hyperglycémiques tels que l’acidocétose diabétique et l’état hyperglycémique hyperosmolaire représentent des situations d’urgence potentiellement létales qui se rencontrent régulièrement au sein services d’urgence, mais auxquelles les collègues installés en cabinet peuvent également être confrontés.
Hyperglykämische Entgleisungen wie die diabetische Ketoazidose und hyperosmolare hyperglykäme Entgleisung stellen potenziell letale Notfallsituationen dar, auf einer Notfallstation regelmässig anzutreffen sind, mit denen aber auch Kolleginnen Kollegen in der Praxis konfrontiert werden können.