A5051742395- Animal testing and alternatives
- Computational Drug Discovery Methods
- Biomedical Text Mining and Ontologies
- Effects and risks of endocrine disrupting chemicals
- Pluripotent Stem Cells Research
- Chemical Safety and Risk Management
- History and advancements in chemistry
- Semantic Web and Ontologies
- Cardiac Ischemia and Reperfusion
- Atmospheric and Environmental Gas Dynamics
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Environmental Justice and Health Disparities
- Radioactivity and Radon Measurements
- Risk Perception and Management
- Data Quality and Management
- Air Quality Monitoring and Forecasting
- Environmental and Social Impact Assessments
- Cardiac electrophysiology and arrhythmias
- Chemistry and Chemical Engineering
- 3D Printing in Biomedical Research
- Healthcare cost, quality, practices
- Immunotoxicology and immune responses
- Air Quality and Health Impacts
- Risk and Safety Analysis
ICF International (United States)
2012-2024
IRCCS Ospedale San Raffaele
2023
Institute of Environmental Engineering
2014
University of North Carolina at Chapel Hill
2013
Background: Benchmark dose (BMD) modeling computes the associated with a prespecified response level. While offering advantages over traditional points of departure (PODs), such as no-observed-adverse-effect-levels (NOAELs), BMD methods have lacked consistency and transparency in application, interpretation, reporting human health assessments chemicals.Objectives: We aimed to apply standardized process for conducting reduce inconsistencies model fitting selection.Methods: evaluated 880...
Background: Human health assessments synthesize human, animal, and mechanistic data to produce toxicity values that are key inputs risk-based decision making. Traditional data-, time-, resource-intensive, they cannot be developed for most environmental chemicals owing a lack of appropriate data. Objectives: As recommended by the National Research Council, we propose solution predicting data-poor through development quantitative structure–activity relationship (QSAR) models. Methods: We used...
Some states and localities restrict siting of new oil gas (O&G) wells relative to public areas. Colorado includes a 500-foot exception zone for building units, but it is unclear if that sufficiently protects health from air emissions O&G operations. To support reviews setback requirements, this research examines potential risks volatile organic compounds (VOCs) released during operations.We used stochastic dispersion modeling with published 47 VOCs (collected on-site tracer experiments)...
Extraction of toxicological end points from primary sources is a central component systematic reviews and human health risk assessments. To ensure optimal use these data, consistent language should be used for point descriptions. However, source describing treatment-related can vary greatly, resulting in large labor efforts to manually standardize extractions before data are fit use.
Harmonized language is essential to finding, sharing, and reusing large-scale, complex data. Gaps barriers prevent the adoption of harmonized approaches in environmental health sciences (EHS). To address this, National Institute Environmental Health Sciences partners created Language Collaborative (EHLC). The purpose EHLC facilitate a community-driven effort advance development EHS. forum pinpoint harmonization gaps, of, raise awareness encourage use tools, develop new standards...
Introduction Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics immune-suppressive pathways limiting T-cell mediated anti-tumor immunity. Methods In this observational study we analyzed by immunohistochemistry, gene expression profiling flow cytometry antigenic landscape composition 48 EOC specimens, with focus on...
Abstract Throughput needs, costs of time and resources, concerns about the use animals in hazard safety assessment studies are fueling a growing interest adopting new approach methodologies for product development risk assessment. However, current efforts to define “next-generation assessment” vary considerably across commercial regulatory sectors, an priori definition biological scope data needed assess hazards is generally lacking. We propose that absence clearly defined questions can be...