A5039556894- Effects and risks of endocrine disrupting chemicals
- Climate Change and Health Impacts
- Birth, Development, and Health
- Environmental and Social Impact Assessments
- Health Systems, Economic Evaluations, Quality of Life
- Air Quality and Health Impacts
- Delphi Technique in Research
- Animal testing and alternatives
- Toxic Organic Pollutants Impact
- Clinical practice guidelines implementation
- Sexual Differentiation and Disorders
- Immunotoxicology and immune responses
- Pesticide Exposure and Toxicity
- History and advancements in chemistry
- Ethics in Clinical Research
- Chemical Safety and Risk Management
- Computational Drug Discovery Methods
- Pregnancy and preeclampsia studies
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Carcinogens and Genotoxicity Assessment
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Chromatography
- Estrogen and related hormone effects
National Institute of Environmental Health Sciences
2019-2025
National Institutes of Health
1991-2025
Environmental Protection Agency
2014-2020
Oak Ridge Institute for Science and Education
2014-2019
Oak Ridge Associated Universities
2014-2019
National Center for Environmental Assessment (EPA)
2018-2019
National Institute of Allergy and Infectious Diseases
1989-1991
Background: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although plays an important role in hazard identification integration, process identifying, screening analyzing studies outcomes is a challenging exercise due diversity research models methods variety known proposed pathways chemical-induced toxicity. Ten key characteristics carcinogens provide...
The aim of this study is to propose an approach for developing trustworthy recommendations as part urgent responses (1-2 week) in the clinical, public health, and health systems fields.
Nongenetic, environmental factors contribute to maternal morbidity and mortality through chemical exposures via air, water, soil, food, consumer products. Pregnancy represents a particularly sensitive window of susceptibility during which physiological changes every major organ system increase sensitivity chemicals that can impact woman's long-term health. Nonchemical stressors, such as low socioeconomic status, may exacerbate the effects on Racial/ethnic minorities are exposed...
Cytokines are immunoregulatory proteins that secreted by T lymphocytes and other cells upon activation. A controversy exists as to whether the induction of cytokine production is mediated at transcriptional level initiation RNA synthesis or post-transcriptional enhancement mRNA stability. We show in a nontransformed cell clone all cytokines analyzed this report transcriptionally. also found constitutive signal was seen resting when probes used nuclear run-on assay contained some potential...
Sex differentiation of the male reproductive tract in mammals is driven, part, by fetal androgen production. In utero, some phthalate esters (PEs) alter Leydig cell differentiation, reducing expression several genes associated with steroid synthesis/transport, and consequently, lowering Insl3 hormone levels. Simvastatin (SMV) a cholesterol-lowering drug that directly inhibits HMG-CoA reductase. SMV may also disrupt biosynthesis, but through different mode action (MOA) than PEs. As...
A minor T cell determinant from pigeon cytochrome c, composed of residues 43 to 58 (p43-58), was synthesized along with a series 48 analogs containing amino or carboxyl-terminal deletions single acid substitutions. These peptides were analyzed functionally for their ability elicit unique populations on immunization C57BL/10 mice and stimulate degenerate clone capable recognizing p43-58 in association two different Ia molecules, beta b:A alpha b d:A d. experiments allowed us identify the that...
Decision considerations in EOH are accommodated within the GRADE EtD framework.• Limited uptake of is likely due to other factors and not incompatibility framework with decision-making considerations.• Guidance for users essential improve framework's applicability EOH. What this adds what was known• There currently six frameworks different types decisions: individual-and population-level clinical recommendations, health system public coverage decisions, diagnostic test recommendations.• This...