A5046597360- Respiratory Support and Mechanisms
- Health, Medicine and Society
- Venous Thromboembolism Diagnosis and Management
- Healthcare Systems and Practices
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Antibiotic Use and Resistance
- Amyotrophic Lateral Sclerosis Research
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- Neurogenetic and Muscular Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Central Venous Catheters and Hemodialysis
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Spinal Dysraphism and Malformations
- Healthcare cost, quality, practices
- Antimicrobial Resistance in Staphylococcus
- Diabetic Foot Ulcer Assessment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Healthcare professionals’ stress and burnout
- Diphtheria, Corynebacterium, and Tetanus
Guy's and St Thomas' NHS Foundation Trust
2021-2025
University of Geneva
2019-2025
Hôpital Beau-Séjour
2024
University Hospital of Geneva
2019-2024
St Thomas' Hospital
2024
Geneva College
2020
Institution Genevoise de Maintien à Domicile
2017-2019
Antibiotic overuse drives antibiotic resistance. Gram-negative bacteremia is a common infection that results in substantial use.To compare the clinical effectiveness of C-reactive protein (CRP)-guided, 7-day, and 14-day durations 30, 60, 90 days after treatment initiation.Multicenter, noninferiority, point-of-care randomized trial including adults hospitalized with gram-negative conducted 3 Swiss tertiary care hospitals between April 2017 May 2019, follow-up until August 2019. Patients...
Abstract Surface electromyography (sEMG) can be used to measure the electrical activity of respiratory muscles. The possible applications sEMG span from patients suffering acute failure receiving chronic home mechanical ventilation, evaluate muscle function, titrate ventilatory support and guide treatment. However, is mainly as a monitoring tool for research its use in clinical practice still limited—in part due lack standardization transparent reporting. During this round table meeting,...
Patients recovering from severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a 30-day readmission rate 20%. This study evaluated the feasibility conducting randomised controlled trial to evaluate clinical, patient-reported and physiological effects home high-flow therapy (HFT) in addition usual medical therapy, eucapnic patients AECOPD support design phase 3 trial. A mixed-methods (quantitative primacy, concurrently embedded qualitative evaluation)...
Through the analysis of notable studies from 2024, this article offers an overview key advances in internal medicine with a selection essential themes. The topics covered include common conditions such as cardiovascular diseases, pulmonary disorders, antibiotic use, and fever unknown origin. This provides practical summary to help clinicians stay informed about latest diagnostic therapeutic developments.
<b><i>Background:</i></b> The COVID-19 pandemic has led to shortage of intensive care unit (ICU) capacity. We developed a triage strategy including noninvasive respiratory support and admission the intermediate (IMCU). ICU was restricted patients requiring invasive ventilation. <b><i>Objectives:</i></b> aim this study is describe characteristics outcomes admitted IMCU. <b><i>Method:</i></b> Retrospective cohort...
Summary Objective The appropriate duration of antibiotic therapy for diabetic foot infections (DFI) after surgical amputations in toto is debated. There are discrepancies worldwide. Methods Using a clinical pathway adult DFI patients (retrospective cohort analysis), we conducted cluster‐controlled Cox regression analysis. Minimum follow‐up was 2 months. Results We followed 482 amputated episodes median 2.1 years the index episode. DFIs predominately affected forefoot (n = 433; 90%)....
The aim of this study was to determine the prevalence and forms gender discrimination sexual harassment experienced by medical students physicians in French-speaking part Switzerland.We conducted an online survey using a questionnaire 9 multiple-choice 2 open questions between 24 January 2019 February 2019. Our target population working at hospitals general practitioners from Switzerland. sent via social media platforms direct emails. We compared answers male-determined female-determined...
Introduction Antibiotic overuse drives antibiotic resistance. The optimal duration of therapy for Gram-negative bacteraemia (GNB), a common community and hospital-associated infection, remains unknown unstudied via randomised controlled trials (RCTs). Methods analysis This investigator-initiated, multicentre, non-inferiority, informatics-based point-of-care RCT will randomly assign adult hospitalised patients receiving microbiologically efficacious antibiotic(s) GNB to (1) 14 days therapy,...
In amyotrophic lateral sclerosis (ALS), non-invasive ventilation (NIV) improves survival; however, the phenotype of patients who are most likely to benefit remains unclear. This study aimed identify predictors survival at initiation NIV. A retrospective review (September 2018 - June 2022) with ALS initiated on NIV a tertiary referral centre was conducted. Survival analysis performed Cox regression model. 105 (56% male) (69% limb-onset, 31% bulbar-onset) received new treatment. Age (mean±SD)...
Sniff nasal inspiratory pressure (SNIP) is used to assess respiratory muscle strength in neuromuscular diseases like amyotrophic lateral sclerosis (ALS). The effect of contralateral nostril occlusion and mouth sealing on SNIP measurement are unclear. 81 participants were included (16 healthy, 39 patients with limb-onset ALS 26 bulbar-onset ALS). was obtained combinations open/sealed open/occluded. Occluding the (with closed) increased by 12 cmH 2 O (95% CI 4, 20; p=0.003) healthy...
Home nasal high flow (hNHF) may improve outcomes in hypoxaemic COPD patients. Those recovering from acute exacerbations (AECOPD) are at risk of readmission or re-exacerbation. We conducted a mixed-methods randomised controlled trial to determine the feasibility phase III evaluating effect hNHF on 30-day following severe AECOPD. Hospitalised patients were receive usual care additional (ISRCTN15949009) discharge. Feasibility was assessed by recruitment, protocol adherence and acceptability....
<b>Introduction:</b> Positional therapy is increasingly prescribed as adjunct for patients ranging from sleep disordered breathing to proning in acute respiratory distress syndrome. Patients with severe obesity are a high risk group these disorders. We examined the effects of different positions on mechanics obesity. <b>Methods:</b> Pre-bariatric surgery clinic were enrolled. Respiratory assessed using balloon catheters oesophageal and gastric pressures during stable tidal...
Patients with amyotrophic lateral sclerosis (ALS) develop chronic respiratory failure, managed non-invasive ventilation (NIV) to improve survival and quality of life. We investigated if baseline clinical features can predict outcome. Baseline data our ALS cohort, initiated on NIV between 01/04/21 01/04/22, were included determine the relationship characteristics mortality. 35 patients (57% male; median(IQR) age 68(56-77) yrs); 69% limb-onset 31% bulbar-onset). are shown in Tab 1. Survival...