A5076399146- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Literature: history, themes, analysis
- Spine and Intervertebral Disc Pathology
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Spinal Fractures and Fixation Techniques
- Scottish History and National Identity
- Historical Art and Culture Studies
- Folklore, Mythology, and Literature Studies
- Organ and Tissue Transplantation Research
- Historical and Literary Studies
- Musculoskeletal pain and rehabilitation
- Shakespeare, Adaptation, and Literary Criticism
- Medical Imaging and Analysis
- Themes in Literature Analysis
- Philippine History and Culture
- Renal Diseases and Glomerulopathies
- Historical Studies of British Isles
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Scoliosis diagnosis and treatment
- Short Stories in Global Literature
- Mechanical Circulatory Support Devices
- Liver Disease Diagnosis and Treatment
University of Dundee
2015-2024
SimBiotic Software (United States)
2022-2023
Vanderbilt University Medical Center
2023
Duquesne University
2022
Allegheny Health Network
2015-2021
Allegheny General Hospital
2011-2020
Brooklyn College
1979-2018
Perth Royal Infirmary
2018
Nia Association
2018
University of Delaware
2012-2018
Progressive nephrotoxicity caused by calcineurin inhibitor drugs contributes to the long-term decline in renal function kidney transplant patients.We conducted a randomized, prospective trial of drug avoidance 61 adult primary recipients. Each patient received induction therapy with 20 mg basiliximab on days 0 and 4, maintenance mycophenolate mofetil 1 g two times per day steroids. Thirty-one patients sirolimus, 5 daily after 15-mg loading dose. Doses were then concentration-controlled keep...
We performed a randomized prospective trial comparing calcineurin inhibitor (CNI)-free to CNI-based immunosuppression determine the impact on renal function, structure and gene expression. Sixty-one kidney recipients treated with basiliximab mycophenolate mofetil (MMF) prednisone (P) were randomly assigned concentration-controlled sirolimus or cyclosporine. Two years post-transplant 55 patients underwent function studies, 48 (87%) transplant biopsies; all classified by Banff scoring 41 DNA...
Background. We report the 5-year outcomes from a randomized prospective trial in primary adult renal allograft recipients, designed to evaluate calcineurin inhibitor (CNI)-free immunosuppression on kidney transplant function. Methods. Sixty-one patients were either sirolimus (n=31) or cyclosporine (n=30) after basiliximab induction and mycophenolate mofetil (MMF) with steroids. Sirolimus was concentration controlled at 10–12 ng/mL for least 6 months. Results. After 5 years,...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jul 2002Cytokine Polymorphisms in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Association Diagnosis and Treatment Response Daniel A. Shoskes, Qussay Albakri, Kim Thomas, Cook ShoskesDaniel Shoskes , AlbakriQussay Albakri ThomasKim Thomas CookDaniel View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64916-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
We treated 2 patients with IgM monoclonal paraproteinemic demyelinating peripheral neuropathy (PPN) monthly intravenous human immunoglobulin. Both had a steadily progressive course in spite of steroid and other immunosuppressive therapy for 3 years before starting the immunoglobulin therapy. rapid clinical improvement noticeable 5 to 10 days after 1st infusion lasting on average 6 weeks. Retreatment caused each consecutive infusion. There were no significant adverse side effects. High-dose...
We performed a pilot study in which 22 kidney recipients (14 LD: 8 DCD) were given alemtuzumab induction (30 mg day 0 and 1), steroids (500 mp 1, none thereafter), mycophenolate mofetil (MMF) maintenance b.i.d) sirolimus (concentration controlled 8-12 ng/mL). With mean follow-up of 15.9 months, patient survival is (21/22) 96% graft (19/22) 87%. Acute rejections occurred (8) 36.3% (two humoral). Of 19 surviving grafts, 18 (95%) remain steroid 15 (79%) CNI-free. At 1 year, creatinine was 1.43...
Objective: The ThinkFirst Canada Smart Hockey program is an educational injury prevention video that teaches the mechanisms, consequences, and of brain spinal cord in ice hockey. This study evaluates knowledge transfer behavioural outcomes 11–12 year old hockey players who viewed video. Design: Randomized controlled design. Setting: Greater Toronto Minor League, Ontario. Subjects: Minor, competitive male team coaches. Interventions: was shown to experimental teams at mid-season. An interview...
Using actuarial methods, factors influencing long-term graft survival were examined in 33,594 recent (since 1974) kidney transplants reported to the University of California, Los Angeles, Transplant Registry. One-and 10-year graft-survival rates as well late (from 3 through 10 years) graft-loss (half-lives) determined. The donor-recipient relationship had greatest influence on survival. Transplants between HLA-identical siblings 89% at 1 year and 68% years, compared with 76% 43% for parental...
A thorough understanding of the biomechanical characteristics healthy human spine is critical in furthering treatment spinal pathology. The goal this study was to investigate motion intact lumbar segment as measured by range (ROM), and dependencies thereof on gender intervertebral level.Kinematic data obtained for 42 segments (L1-S1) response a pure-moment loading protocol flexion extension (FE), lateral bending (LB) axial torsion (AT). Data 204 individual functional units (91 female, 113...
Abstract: Background: The recent development of powerful agents such as mycophenolate mofetil and tacrolimus has altered current regimens for the prevention treatment allograft rejection. Questions have been raised about these newer in terms susceptibility to opportunistic infections effects on host defenses. Severe hypogammaglobulinemia infrequently described solid organ transplant recipients, but recently noted six heart recipients at one center, whom five were receiving a combination...
We performed a sequential study to determine the efficacy and side effects of low-dose (1 g) mycophenolate mofetil (MMF) in CNI drug avoidance regimen including sirolimus/steroids.A total 260 kidney-only recipients were given basiliximab (232) or thymoglobulin (28) induction, sirolimus/steroids. In addition, 160 begun on standard MMF 1 g twice daily (2-g group), while 100 500 mg (1-g group). The 1-g concentration controlled keep mycophenolic acid (MPA) C0 levels at 1.8-4 microg/ml.There no...
Treatment of bipolar disorder with lithium therapy during pregnancy is a medical challenge. Bipolar more prevalent in women and its onset often concurrent peak reproductive age. typically involves administration the element lithium, which has been classified as class D drug (legal to use pregnancy, but may cause birth defects) one only thirty known teratogenic drugs. There no clear recommendation literature on maximum acceptable dosage regimen for pregnant, women. We recommend based...