A5061260539- Breast Cancer Treatment Studies
- Gallbladder and Bile Duct Disorders
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Breast Lesions and Carcinomas
- Cytokine Signaling Pathways and Interactions
- Antioxidant Activity and Oxidative Stress
- Atherosclerosis and Cardiovascular Diseases
- Appendicitis Diagnosis and Management
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- interferon and immune responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Metabolism, Diabetes, and Cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging Techniques and Applications
- Diverticular Disease and Complications
- MRI in cancer diagnosis
- Adipokines, Inflammation, and Metabolic Diseases
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Reconstructive Facial Surgery Techniques
St. Vincent's University Hospital
2023-2025
University of Bristol
2024
Gartnavel General Hospital
2021-2023
Eastbourne District General Hospital
2023
Barts Health NHS Trust
2022
St Bartholomew's Hospital
1995-2022
NHS Greater Glasgow and Clyde
2020-2021
KK Women's and Children's Hospital
2019-2020
Singapore General Hospital
2020
University of Glasgow
2001-2016
The energy-sensing pathway kinase AMPK inhibits proinflammatory JAK1 signaling.
Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion proposed to contribute insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism reported have anti-inflammatory actions tissue, yet the mechanisms underlying this remain poorly characterised. The effect AMPK activation on cytokine-stimulated proinflammatory signalling was therefore assessed cultured adipocytes. inhibited IL-1β-stimulated CXCL10 secretion,...
Abstract Background The B-MaP-C study aimed to determine alterations breast cancer (BC) management during the peak transmission period of UK COVID-19 pandemic and potential impact these treatment decisions. Methods This was a national cohort patients with early BC undergoing multidisciplinary team (MDT)-guided recommendations pandemic, designated ‘standard’ or ‘COVID-altered’, in preoperative, operative post-operative setting. Findings Of 3776 (from 64 units) study, 2246 (59%) had...
Here, we demonstrate that elevation of intracellular cyclic AMP (cAMP) in vascular endothelial cells (ECs) by either a direct activator adenylyl cyclase or endogenous cAMP-mobilizing G protein-coupled receptors inhibited the tyrosine phosphorylation STAT proteins an interleukin 6 (IL-6) receptor trans-signaling complex (soluble IL-6Ralpha/IL-6). This was associated with induction suppressor cytokine signaling 3 (SOCS-3), bona fide inhibitor vivo gp130, signal-transducing component IL-6...
Abstract Although the ability of bioactive lipid sphingosine-1-phosphate (S1P) to positively regulate anti-apoptotic/pro-survival responses by binding S1P 1 is well known, molecular mechanisms remain unclear. Here we demonstrate that expression renders CCL39 lung fibroblasts resistant apoptosis following growth factor withdrawal. Resistance was associated with attenuated accumulation pro-apoptotic BH3-only protein Bim. However, although blockade extracellular signal-regulated kinase (ERK)...
Abstract Background Wire localization is historically the most common method for guiding excision of non-palpable breast lesions, but there are limitations to technique. Newer technologies such as magnetic seeds may allow some these challenges be overcome. The aim was compare safety and effectiveness wire seed techniques. Methods Women undergoing standard or lesions between August 2018 2020 were recruited prospectively this IDEAL stage 2a/2b platform cohort study. primary outcome defined...
Partial breast reconstruction with a pedicled chest wall perforator flap (CWPF) enables conservation in higher tumour: volume ratio scenario. Since there is limited evidence, this retrospective cohort study aimed to ascertain immediate (30-days) and medium-term (follow-up duration) surgical outcomes.STROBE-compliant protocol ascertained CWPF outcomes between March 2011-March 2021. UK centres known perform were invited participate if they performed at least 10 cases. Data retrospectively...
Abstract Background CT thorax, abdomen and pelvis (CT-TAP) remains the standard in identification of metastatic disease patients with newly diagnosed breast cancer. In proven micro macro axillary nodal metastasis, optimal radiological technique controversial. A consensus on which should receive staging for distant how this be performed is not currently available. The aim study was to evaluate yield from disease. Methods Patients invasive cancer a positive sentinel lymph node biopsy (SLNB)...
IntroductionInvasive lobular carcinoma (ILC) accounts for 5–15% of invasive breast cancers. Typical ILC is oestrogen receptor (ER) positive and human epidermal growth factor 2 (HER2) negative. Atypical biomarker profiles (ER- HER2+, ER+ HER2+ or triple negative) appear to differ from typical ILCs. This study compared subtypes in terms clinical pathological parameters, response neoadjuvant chemotherapy (NACT) according profile.MethodsAll patients with treated a single centre January 2005...
Several studies have indicated that growth factors, such as platelet derived factor (PDGF), may be important in atherogenesis. These factors are released from platelets, or expressed by cells of the arterial wall. In order to study their role atherogenesis more directly, rabbits were immunized with PDGF‐BB, cytosolic protein, human serum albumin (HSA), until high titres antibody attained. Atherosclerotic lesions subsequently induced feeding animals a 2% cholesterol enriched diet. At end...
Abstract Purpose UK NICE guidelines recommend axillary node clearance (ANC) should be performed in all patients with biopsy-proven node-positive breast cancer having primary surgery. There is, however, increasing evidence such extensive surgery may not always necessary. Targeted dissection (TAD) an effective alternative low-volume nodal disease who are clinically negative (cN0) but have abnormal nodes detected radiologically. This survey aimed to explore current management of this group...
Here we demonstrate that overexpression of the human A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR) in vascular endothelial cells confers an ability interferon-α and a soluble IL-6 receptor/IL-6 (sIL-6Rα/IL-6) trans-signaling complex to trigger down-regulation signal transducer activator transcription (STAT) proteins. It is noteworthy STAT could be reversed by coincubation with A<sub>2A</sub>AR-selective inverse agonist...
Progressive tension suture (PTS) technique in cosmetic abdominoplasty is safe terms of seroma rates. This was extrapolated to deep inferior epigastric perforator (DIEP) flap donor site closure. No study our knowledge has analyzed the PTS alone without drains transverse rectus abdominis musculocutaneous (TRAM) sites. We aim show that no-drain closure similar complication rates and this may be applied TRAM flaps safely even though they have higher drain output.A single-center, single-surgeon...