A5102809377- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Advances in Oncology and Radiotherapy
- BRCA gene mutations in cancer
- Surgical site infection prevention
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Healthcare cost, quality, practices
- Virus-based gene therapy research
- Cholesterol and Lipid Metabolism
- Wound Healing and Treatments
- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- Inflammatory mediators and NSAID effects
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
St James's University Hospital
2013-2024
Leeds Teaching Hospitals NHS Trust
2013-2024
Liechtenstein Institute
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2021
Ceres Nanosciences
2020
Calderdale and Huddersfield NHS Foundation Trust
2020
Bradford Teaching Hospitals NHS Foundation Trust
2020
York Teaching Hospital NHS Foundation Trust
2020
University of Leeds
2013-2018
Airedale General Hospital
2018
Abstract Background The B-MaP-C study aimed to determine alterations breast cancer (BC) management during the peak transmission period of UK COVID-19 pandemic and potential impact these treatment decisions. Methods This was a national cohort patients with early BC undergoing multidisciplinary team (MDT)-guided recommendations pandemic, designated ‘standard’ or ‘COVID-altered’, in preoperative, operative post-operative setting. Findings Of 3776 (from 64 units) study, 2246 (59%) had...
Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as it known to be up-regulated by chemotherapeutics. Our aims this study were determine whether activation of Notch signalling responsible for chemotherapy-induced MRP1 expression breast cancers, pathway manipulated with an inhibitor activity. Notch1 investigated 29 patients treated neoadjuvant chemotherapy (NAC) cancer, using...
<h3>Background</h3> NICE guidance exists for the use of faecal calprotectin (FC) when irritable bowel syndrome or inflammatory disease are suspected. Often, however, colorectal cancer is considered within differential. Should FC have a high diagnostic accuracy cancer, it may be applicable as primary care screening test all patients with lower gastrointestinal symptoms. <h3>Aim</h3> To determine negative and positive predictive value (NPV/PPV) in referred from suspected cancer. <h3>Design...
Three main xenobiotic efflux pumps have been implicated in modulating breast cancer chemotherapy responses. These are P-glycoprotein (Pgp), Multidrug Resistance-associated Protein 1 (MRP1), and Breast Cancer Resistance (BCRP). We investigated expression of these proteins cancers before after neoadjuvant (NAC) to determine whether their levels define response NAC or subsequent survival. Formalin-fixed paraffin-embedded tissues were collected representing matched pairs core biopsy (pre-NAC)...
Abstract Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy typically restricted cytotoxic chemotherapy, which fails more often in patients with elevated circulating cholesterol. Liver x receptors are ligand-dependent transcription factors that homeostatic regulators of cholesterol, and linked regulation broad-affinity xenobiotic transporter activity non-tumor tissues. We show LXR ligands confer...
Partial breast reconstruction with a pedicled chest wall perforator flap (CWPF) enables conservation in higher tumour: volume ratio scenario. Since there is limited evidence, this retrospective cohort study aimed to ascertain immediate (30-days) and medium-term (follow-up duration) surgical outcomes.STROBE-compliant protocol ascertained CWPF outcomes between March 2011-March 2021. UK centres known perform were invited participate if they performed at least 10 cases. Data retrospectively...
Background: Adherence to the World Cancer Research Fund (WCRF) and American Institute for (AICR) cancer prevention guidelines is linked lower incidence improved outcomes. However, relationship between these chemotherapy response, particularly in Triple Negative Breast Cancer, not well understood. TNBC has poorest survival rates among breast subtypes, with only 32% of patients achieving pathological complete response after neoadjuvant chemotherapy. Predicting which will respond gain benefits...
Objective: Triple-negative breast cancer (TNBC) patients with excess adipose tissue experience poorer disease-free survival than those a healthy body mass index. Adipocytes, abundant in mammary tissue, store and release cholesterol, which can be hydroxylated to form oxysterols. These cholesterol derivatives activate the liver X receptor (LXR) pathway. This study tested hypothesis that adipocytes contribute an imbalanced tumour-microenvironment by exposing cells elevated oxysterols, mimicking...
Abstract Background Therapeutic mammaplasty, which combines breast reduction and mastopexy techniques with tumour excision, may extend the boundaries of breast-conserving surgery improve outcomes for patients, but current practice is unknown high-quality outcome data are lacking. This prospective multicentre cohort study aimed to explore short-term technique. Methods Consecutive patients undergoing therapeutic mammaplasty at participating centres between 1 September 2016 30 June 2017 were...
Abstract Background Therapeutic mammaplasty (TM) may be an alternative to mastectomy, but few well designed studies have evaluated the success of this approach or compared short-term outcomes TM with mastectomy without immediate breast reconstruction (IBR). Data from national iBRA-2 and TeaM were combined compare safety IBR. Methods The subgroup patients in study who underwent avoid identified, data on demographics, complications, oncology adjuvant treatment those undergoing IBR study....
Wide local excision and adjuvant radiotherapy is the standard of care for early breast cancer. For large tumours, however, mastectomy frequently recommended as conventional breast-conserving techniques often result in poor cosmetic outcomes. Therapeutic mammaplasty (TM) may extend boundaries surgery by combining reduction mastopexy with tumour excision, preserving a natural shape avoiding need mastectomy. The prevalence this operative option among surgeons UK its success rate are unknown....
Introduction The COVID-19 pandemic caused widespread changes in delivery of breast cancer care, aiming to protect vulnerable patients whilst minimising compromise oncological outcomes. This multicentre observational study aimed establish early surgical outcomes from surgery performed during the peak pandemic. Materials and methods Data were collected on consecutive that underwent four units between 16 March 24 April 2020. Outcome data at 30 days post-operation collected, including documented...
Approximately 55,000 women in the United Kingdom are diagnosed with new breast cancer annually. Since emerging December 2019, SARS-CoV-2 (coronavirus disease COVID-19) has become a global pandemic, affecting healthcare delivery worldwide. In response to multiple guidelines were issued assist rationalising care. The primary aim of B-MaP-C study is audit and describe management patients newly during COVID-19 pandemic against pre-COVID-19 practice UK. implications changes will be determined...
Abstract Background Breast cancer stem cells (BCSCs) are drivers of therapy-resistance, therefore responsible for poor survival. Molecular signatures BCSCs from primary cancers remain undefined. Here, we identify the consistent transcriptome shared across breast subtypes, and examine clinical relevance ITGA7, one genes differentially expressed in BCSCs. Methods Primary were assessed using immunohistochemistry fluorescently labelled Aldefluor ( n = 17). Transcriptomes sorted matched non-stem...
Background: Despite a UK 5-year breast cancer survival rate of 86.6%, patients may develop recurrence within the same after conserving surgery, as well in remaining skin or chest wall mastectomy ipsilateral lymph glands. These recurrences, collectively termed locoregional (LRR), occur around 8% 10 years their original diagnosis. Currently, there is lack robust information on presentation and prevalence LRR with no UK-specific clinical guidelines available for optimal management this patient...
Therapeutic mammaplasty (TM) facilitates large tumour resection while maintaining optimal aesthetic outcome. It carries higher wound complication risks, which may delay adjuvant therapy initiation. Whether this affects oncological outcome requires evaluation. Data were collected for consecutive patients receiving TM at the Leeds breast unit (2009-2017). A prospectively maintained database was used to determine characteristics, rates, receipt of and cancer recurrence or death. In total 112...
Evidence based guidelines for the optimal management of breast cancer locoregional recurrence (LRR) are limited, with potential variation in clinical practice. This national practice questionnaire (NPQ) was designed to establish current UK multidisciplinary teams (MDTs) regarding LRR management.UK units were invited take part MARECA study MDT NPQ. Scenario-based questions used elicit preference pre-operative staging investigations, surgical management, and adjuvant therapy.822 members across...
Abstract Purpose The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they awaiting surgery due reprioritisation resources. Methods This multicentre, multinational cohort recruited 6045 from UK, Spain and Portugal during peak pandemic period (Feb–July 2020). Patients BrET followed up investigate duration of, response to, BrET....