A5084811113- Liver Diseases and Immunity
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Toxoplasma gondii Research Studies
- Cancer Cells and Metastasis
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Parasites and Host Interactions
- Urinary and Genital Oncology Studies
- PI3K/AKT/mTOR signaling in cancer
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Parasite Biology and Host Interactions
- Biological Research and Disease Studies
- Angiogenesis and VEGF in Cancer
- Mycobacterium research and diagnosis
- Helminth infection and control
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
Alexandria University
2002-2023
Qassim University
2007
A growing body of evidence supports the concept helminths therapy in a variety autoimmune diseases. Here, we aimed to investigate protective effects autoclaved Schistosoma mansoni antigen (ASMA) and Trichinella spiralis (ATSA) on clinical immunopathological features rheumatoid arthritis (RA). Adjuvant was induced by subcutaneous intradermal injections complete Freund’s adjuvant into plantar surface right hind paw root tail, respectively. Rats were randomly assigned serve as normal control,...
Pathogen-based cancer vaccine is a promising immunotherapeutic weapon to stimulate immunosuppressive state. Toxoplasma gondii potent immunostimulant, and low-dose infection was linked resistance. Our goal evaluate the therapeutic antineoplastic activity of autoclaved (ATV) against Ehrlich solid carcinoma (ESC) in mice reference combination with cyclophosphamide (CP), immunomodulator. Mice inoculation ESC followed by applying different treatment modalities including ATV, CP, CP/ATV. We...
Abstract Background With cancer cases escalation, an urgent request to develop novel combating strategies arise. Pathogen-based cancer-immunotherapy is getting more consideration. Autoclaved parasitic antigens seem promising candidates, taking steadily their first steps. Our aim was examine the prophylactic antineoplastic activity of autoclaved Toxoplasma vaccine (ATV) and test for shared antigen theory between gondii cells. Methods Mice were immunized with ATV followed by Ehrlich solid...
AbstractObjectives : This prospective study was done to demonstrate the effect of repeated resection superficial bladder tumors (TURT) on deep malignant cell infiltration in wall. Material and Methods Thirty-six patients underwent radical cystectomy for invasive cancer, 16 originally had cancer that became after TURT (group I) other 20 II) presented with from start. Each specimen subjected a thorough histopathological study. Results There statistically significant difference pattern local...
Abstract Background Breast cancer stem cells (BCSCs) are drivers of therapy-resistance, therefore responsible for poor survival. Molecular signatures BCSCs from primary cancers remain undefined. Here, we identify the consistent transcriptome shared across breast subtypes, and examine clinical relevance ITGA7, one genes differentially expressed in BCSCs. Methods Primary were assessed using immunohistochemistry fluorescently labelled Aldefluor ( n = 17). Transcriptomes sorted matched non-stem...
The aim of this study was to investigate the cytotoxic potency live Toxoplasma gondii tachyzoites as well antigen on MCF-7 human breast cancer cell line. Cancer lines are considered an essential preliminary step towards in-vitro investigation potential antineoplastic impact novel chemotherapeutic agents. Pathogens, including viruses, bacteria, and parasites noticeably under investigation, considering their activity. Some have attained a steady position in clinical field hepatitis B virus,...
The conventional osteosarcoma (OS) is the commonest primary malignant, bone tumor with complex genomic profiles and poor survival. Runt-related transcription factor 2 (RUNX2) WW domain containing oxidoreductase (WWOX) genes are implicated in normal osteogenesis as well development of OS. We retrospectively assessed protein RNA expression RUNX2 WWOX by quantitative real time PCR (qPCR) immunohistochemistry (IHC) 80 cases OS 20 control (NC) subjects. Proteins levels both were correlated to...
From the results of current study, it can be concluded that:• CD8 cytotoxic T lymphocytes were associated with good prognostic parameters.• While FOXP3 (Treg) poor parameters in breast cancer patients.•CD8 and used as potential markers cancer.
<h3>Introduction</h3> T helper (Th)17 cells, a newly identified subset of Th are major mediators inflammation-associated disease and have reciprocal developmental relationship with the immunosuppressive regulatory (Treg) which actively restrain inflammatory response. The present work was designed to study balance between Th17 cells Treg in patients chronic hepatitis C (CHC) relation activity severity hepatic fibrosis. <h3>Methods</h3> Twenty treatment-naive CHC 20 healthy subjects were...
Background: Cancer cervix constitutes a major health problem worldwide. It is one of the most common female malignancy in both incidence and mortality. has many risk factors, important persistent infection with HPV high types. Its morbidity mortality can be reduced by frequent screening early diagnosis. So that, several studies have been conducted recent years order to find better tests for pre-invasive disease so intervention prognosis. This study aimed compare sensitivity Pap test DNA as...