A5061663604- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Estrogen and related hormone effects
- Immune cells in cancer
- Acupuncture Treatment Research Studies
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Steroid Chemistry and Biochemistry
- Neuroscience of respiration and sleep
- Tannin, Tannase and Anticancer Activities
- Pain Mechanisms and Treatments
- Cancer Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- HER2/EGFR in Cancer Research
- Hydrogen's biological and therapeutic effects
- Edible Oils Quality and Analysis
- Nuclear Receptors and Signaling
- Liver Diseases and Immunity
- Extracellular vesicles in disease
- Odor and Emission Control Technologies
- Artificial Intelligence in Healthcare
Nanjing Tech University
2024-2025
AbbVie (United States)
2025
University of Illinois Urbana-Champaign
2018-2024
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2022-2023
Chinese PLA General Hospital
2017-2020
Urbana University
2020
Bayi Children's Hospital
2018
Abstract Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates is poorly understood. Here we show in male mice that hypercholesterolemia-driven endothelial activation, monocyte recruitment atherosclerotic lesion formation promoted by a crosstalk between macrophages cells mediated cholesterol metabolite 27-hydroxycholesterol (27HC). The pro-atherogenic actions macrophage-derived 27HC...
Abstract The tumor microenvironment (TME) is complex and significantly influences how patients respond to immunotherapy. Despite decades of research generating numerous gene signatures describe the TME, there no consensus on best way capture meaningful variation, as commonly used are heavily T cell-biased with high degrees collinearity. To better understand TME dynamics represent them consistently interpretably, we developed a framework for immunophenotyping using disparate immuno-oncology...
There is an urgent need for more effective strategies to treat ovarian cancer. Elevated cholesterol levels are associated with a decreased progression-free survival time (PFS) while statins protective. 27-Hydroxycholesterol (27HC), primary metabolite of cholesterol, has been shown modulate the activities estrogen receptors (ERs) and liver x (LXRs) providing potential mechanistic link between cancer progression. We found that high expression CYP27A1, enzyme responsible synthesis 27HC, was...
Abstract Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy typically restricted cytotoxic chemotherapy, which fails more often in patients with elevated circulating cholesterol. Liver x receptors are ligand-dependent transcription factors that homeostatic regulators of cholesterol, and linked regulation broad-affinity xenobiotic transporter activity non-tumor tissues. We show LXR ligands confer...
Abstract Cholesterol has been implicated in the clinical progression of breast cancer, a disease that continues to be most commonly diagnosed cancer women. Previous work identified cholesterol metabolite 27-hydroxycholesterol (27HC) as major mediator effects on tumor growth and progression. 27HC can act an estrogen receptor (ER) modulator promote ERα+ tumors, liver X (LXR) ligand myeloid immune cells establish immune-suppressive program. In fact, metastatic properties require presence with...
Immune checkpoint blockade (ICB) has had limited utility in several solid tumors such as breast cancer, a major cause of cancer-related mortality women. Therefore, there is considerable interest alternate strategies to promote an anti-cancer immune response. A paper co-published this issue describes how NR0B2, protein involved cholesterol homeostasis, functions within myeloid cells modulate the inflammasome and reduce expansion immune-suppressive regulatory T (T
Although survival from breast cancer has dramatically increased, many will develop recurrent, metastatic disease. Unfortunately, for this stage of disease remains very low. Activating the immune system incredible promise since it potential to be curative. However, checkpoint blockade (ICB) which works through T cells been largely disappointing cancer. One reason is a suppressive myeloid compartment that unaffected by ICB. Cholesterol metabolism and proteins involved in cholesterol...
Diabetic neuropathic pain (DNP) is a common complication of diabetes. Streptozotocin (STZ)-induced changes protein in dorsal root ganglion (DRG) and spinal cord horn (SCDH) are critical for DNP genesis. However, which proteins change remains elusive. Here, the model was established by single intraperitoneal injection STZ, accompanied increased fasting blood glucose (FBG), decreased body weight (BW), paw withdrawal latency (PWL). Proteins L4-L6 DRGs SCDH rats were detected. Western blot...
Abstract Dysregulation of cholesterol homeostasis is associated with many diseases such as cardiovascular disease and cancer. Liver X receptors (LXRs) are major upstream regulators activated by endogenous metabolites 27-hydroxycholesterol (27HC). LXRs various LXR ligands 27HC have been described to influence several extra-hepatic biological systems. However, disparate reports function emerged, especially respect immunology cancer biology. This would suggest that, similar steroid nuclear...
Abstract The involvement of small heterodimer partner (SHP) in the inhibition hepatic bile acid synthesis from cholesterol has been established. However, extrahepatic expression SHP implies that may have regulatory functions other than those liver. Here, we find mRNA is high murine bone marrow cells, suggesting a physiological role within macrophages. Indeed, macrophages decreases transcriptional activity and nuclear localization factor κB, whereas downregulation opposite effects. Expression...
Electroacupuncture (EA) at ST36 can improve the survival rate in rats after hemorrhagic shock (HS). The current study investigated with 60% blood loss. 144 were divided into four groups: hemorrhage without fluid resuscitation (HS), EA (EA), delayed (DFR), and (EA + DFR). biological parameters 0, 3, 12, 24 h HS investigated. of DFR was significantly higher than that DFR. 12 hemorrhage, level mean arterial pressure DFR, levels renal flow, intestinal mucosal hepatic flow also those Three hours...
Abstract Machine learning algorithms identify patterns that would otherwise be difficult to observe in high-dimensional molecular and clinical data. For this reason, machine has the potential have a profound impact on decision making drug target discovery. Nevertheless, there remain considerable technical challenges adapting these tools for use. These include feature engineering, model selection, defining optimal strategies training. cancer care, RNA sequencing of patient tumor biopsies...
To explore the effect of dimethyl sulfoxide(DMSO) on suppressing release gut inflammatory cytokine and re-store barrier impairment following zymosan-insulted systemic response syndrome (SIRS).S D rats were randomly divided into four groups:sham with administration normal saline (SS group); sham DMSO (DS zymosan (ZS (ZD group), each group includes two subgroups at 4 h 24 after surgery. At intraperitoneal injection (750 mg/kg), levels intestinal cytokines (tumor necrosis factor-αand...
Abstract Ovarian cancer continues to have a high mortality and recurrence rate. Hence, there is an urgent need develop new therapeutic or lifestyle strategies. In this regard, epidemiologic studies implicated elevated cholesterol as negative prognostic factor. Conversely, ovarian patients prescribed cholesterol-lowering drugs (HMGCoA-R inhibitors; statins) exhibit significantly increased progression-free survival (PFS). cohort of 134 patients, we found LDL (≥130 mg/dL) also associated with...
Abstract Immune checkpoint blockade has had underwhelming responses in breast cancer, part due to the highly immune suppressive microenvironment. As a result, cancer continues be second most common cancer-related mortality amongst women, providing strong rationale for development of new therapeutic approaches. Elevated circulating cholesterol is poor prognostic, while patients taking cholesterol-lowering drugs display increased time recurrence. We and others have previously demonstrated that...
Abstract Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy typically restricted cytotoxic chemotherapy, which fails more often in patients with elevated circulating cholesterol. Liver x receptors are ligand-dependent transcription factors that homeostatic regulators of cholesterol, and linked regulation broad-affinity xenobiotic transporter activity non-tumor tissues. We show LXR ligands confer...