A5023244823- Diabetes Management and Research
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Diabetes and associated disorders
- COVID-19 and healthcare impacts
- Pancreatic function and diabetes
- Adolescent and Pediatric Healthcare
- Global Cancer Incidence and Screening
- Cardiac, Anesthesia and Surgical Outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Economic and Financial Impacts of Cancer
- Lymphatic System and Diseases
- Systemic Sclerosis and Related Diseases
- Healthcare cost, quality, practices
- Breast Cancer Treatment Studies
- Grief, Bereavement, and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Breast Cancer Therapies
- Antiplatelet Therapy and Cardiovascular Diseases
- Child and Adolescent Health
- Esophageal Cancer Research and Treatment
- Dermatologic Treatments and Research
- Eosinophilic Esophagitis
- Cancer Diagnosis and Treatment
University of Manchester
2019-2025
Manchester Academic Health Science Centre
2020-2025
Centre for Mental Health
2023-2024
Wythenshawe Hospital
2023
Manchester University NHS Foundation Trust
2023
Farr Institute
2019
In persons with type 1 diabetes and high glycated hemoglobin levels, the benefits of intermittently scanned continuous glucose monitoring optional alarms for low blood levels are uncertain.
The prescription of antipsychotics to children and adolescents has been increasing worldwide. We described up-to-date trends in antipsychotic prescribing identified likely indications a contemporary English cohort.We used large primary care database, the Clinical Practice Research Datalink (CPRD) Aurum we included all aged 3-18 years database registered England between Jan 1, 2000, Dec 31, 2019, excluding those whose gender was recorded as indeterminate. Participants were followed up until...
Abstract Background The B-MaP-C study aimed to determine alterations breast cancer (BC) management during the peak transmission period of UK COVID-19 pandemic and potential impact these treatment decisions. Methods This was a national cohort patients with early BC undergoing multidisciplinary team (MDT)-guided recommendations pandemic, designated ‘standard’ or ‘COVID-altered’, in preoperative, operative post-operative setting. Findings Of 3776 (from 64 units) study, 2246 (59%) had...
Few studies have investigated the effect of COVID-19 pandemic on mental health beyond 2020. This study quantifies changes to healthcare utilisation and symptoms for common problems over pandemic's first 21 months.Parallel cohort using primary care database survey data adults (≥16 years) in England from January 2015 December 2021: 16,551,842 Clinical Practice Research Datalink (CPRD) 40,699 UK Household Longitudinal Survey (UKHLS). Interrupted time-series models estimated monthly prevalence...
Women with breast pain constitute >20% of clinic attendees.
Introduction Optimising glycaemic control in type 1 diabetes (T1D) remains challenging. Flash glucose monitoring with FreeStyle Libre 2 (FSL2) is a novel alternative to the current standard of care self-monitoring blood (SMBG). No randomised controlled trials date have explored potential benefits FSL2 T1D. We aim assess impact people suboptimal T1D comparison SMBG. Methods This open-label, multicentre, (via stochastic minimisation), parallel design study conducted at eight UK secondary and...
This study examines the safety and feasibility of same-day discharge (SDD) in patients undergoing percutaneous coronary intervention (PCI) to chronic total occlusions (CTOs) explores independent associations clinical procedural characteristics with SDD.
Abstract Background To address if the long-standing association between maternal infection, depression/anxiety in pregnancy, and offspring neurodevelopmental disorder (NDD) is causal, we conducted two negative-control studies. Methods Four primary care cohorts of UK children (pregnancy, 1 2 years prior to siblings) born January 1990 31 December 2017 were constructed. NDD included autism/autism spectrum disorder, attention-deficit/hyperactivity intellectual disability, cerebral palsy,...
Little information is available on the clinical trajectories of children and adolescents who attend general practice (GP) with psychiatric symptoms. We aimed to examine 5-year service use in English primary care for neurodevelopmental or mental health symptoms diagnoses. In this retrospective cohort study, we used anonymised records from Clinical Practice Research Datalink Aurum database (CPRD-Aurum). identified (aged 3-18 years) presenting England between Jan 1, 2000, May 9, 2016, a symptom...
The monarchE study added the CDK4/6 inhibitor abemaciclib to care of women with oestrogen-positive (ER+) breast cancers. Eligibility required meeting criteria—either >3 positive axillary nodes, or 1–3 sentinel nodes (SNB+) tumour size >50 mm grade 3 Women were advised proceed completion node clearance (cANC) if size/grade criteria not fulfilled for be identified. However, cANC is associated significant morbidity, conflicting potential benefits abemaciclib. We analysed data 229...
Abstract Objective We previously showed that intermittently scanned continuous glucose monitoring (isCGM) reduces HbA1c at 24 weeks compared with self‐monitoring of blood finger pricking (SMBG) in adults type 1 diabetes and high levels (58–97 mmol/mol [7.5%–11%]). aim to assess the economic impact isCGM SMBG. Methods Participant‐level baseline follow‐up health status (EQ‐5D‐5L) within‐trial healthcare resource‐use data were collected. Quality‐adjusted life‐years (QALYs) derived weeks,...
Objective To assess health-related quality of life in patients with non-dysplastic Barrett’s oesophagus (NDBO) and endoscopically treated dysplastic (DBO). Design This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance healthy individuals. Fisher’s exact Spearman’s rank correlation tests used for analysis. Propensity score...
This study assessed a) the impact of playing Dignity board game on participants' understanding respectful maternal and newborn care b) perceptions how influenced their subsequent practice in Malawi Zambia.
Abstract Purpose The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they awaiting surgery due reprioritisation resources. Methods This multicentre, multinational cohort recruited 6045 from UK, Spain and Portugal during peak pandemic period (Feb–July 2020). Patients BrET followed up investigate duration of, response to, BrET....
We explore whether same day discharge (SDD) is a feasible and safe practice following rotational atherectomy (ROTA) treatment during elective percutaneous coronary intervention (PCI), examine which baseline characteristics are independently associated with SDD.
Infertility randomized controlled trials (RCTs) are often too small to detect realistic treatment effects. Large observational studies have been proposed as a solution. However, this strategy threatens weaken the evidence base further, because non-random assignment treatments makes it impossible distinguish effects of from confounding factors. Alternative solutions required. Power in an RCT can be increased by adjusting for prespecified, prognostic covariates when performing statistical...
Background: Financial pressures for reducing hospitalization costs have driven to a move toward same day discharge (SDD) following uncomplicated percutaneous coronary intervention. The UK healthcare system has transitioned predominantly SDD elective This study aimed examine patient’s clinical, procedural, and institutional characteristics that are associated with the increased adoption of over time in United Kingdom determine whether these vary by region. Methods: data were derived from...
Clinical trials assessing systemic sclerosis (SSc)-related digital ulcers have been hampered by a lack of reliable outcome measures healing. Our objective was to assess the feasibility patients collecting high-quality mobile phone images their lesions as first step in developing smartphone-based measure.Patients with SSc-related (finger) photographed one or more each day for 30 days using smartphone and uploaded secure Dropbox folder. Image quality assessed six criteria: blurriness, shadow,...
Background: There is limited data around drivers of changes in mortality over time. We aimed to examine the temporal mortality, and understand determinants time.Methods: All patients from British Cardiovascular Intervention Society (BCIS) database who were aged between 18-100 years underwent Percutaneous Coronary (PCI) for Acute Myocardial Infarction (AMI) England Wales 2006 2021 included. decomposed contributing factors difference observed proportions using Fairlie decomposition method....
This corrects the article doi: 10.25270/jic/21.00036.
A Correction to this paper has been published: https://doi.org/10.1038/s41416-021-01378-x