A5019190720- Melanoma and MAPK Pathways
- HER2/EGFR in Cancer Research
- Synthesis and biological activity
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Cardiac Imaging and Diagnostics
- Cell Adhesion Molecules Research
- Advanced Breast Cancer Therapies
- Dermatological and COVID-19 studies
- Infectious Encephalopathies and Encephalitis
- Computational Drug Discovery Methods
- PI3K/AKT/mTOR signaling in cancer
- Mechanical Circulatory Support Devices
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Issues in Pregnancy
- Takotsubo Cardiomyopathy and Associated Phenomena
- Protein Kinase Regulation and GTPase Signaling
- Retinal and Optic Conditions
- Cardiovascular Health and Risk Factors
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Bone health and treatments
- Advanced Proteomics Techniques and Applications
- Parvovirus B19 Infection Studies
Icahn School of Medicine at Mount Sinai
2020-2025
Wythenshawe Hospital
2021-2024
University of Manchester
2021-2024
Mount Sinai Health System
2020-2024
MemorialCare Health System
2020-2024
Montefiore Health System
2022-2023
Stony Brook University
2022
Temple University Hospital
2021
The Christie NHS Foundation Trust
2012
Central nervous system (CNS) viral infections result in the clinical syndromes of aseptic meningitis or encephalitis. Although primary target coronavirus disease 2019 (COVID-19) is respiratory system, it increasingly being recognized as a neuropathogen. The hallmark feature altered mental status, ranging from mild confusion to deep coma. Most patients with encephalopathy encephalitis are critically ill. We present case COVID-19-related who presented acute delirium and new-onset seizures....
Ventricular fibrillation (VF) is often associated with underlying structural heart disease and occurs in a small percentage of acute myocardial infarction (MI) cases. Specific conditions such as complete coronary occlusion, anterior wall infarction, pre-existing like atrial or congenital abnormalities increase the risk VF. In this report, we present case 64-year-old male history hypertension, HIV, opioid dependence who developed VF during stress testing despite having no prior disease. This...
Refractory coronary artery spasm is a challenging condition with many complications, including acute myocardial infarction. We present the case of an elderly woman who developed refractory vasospasm requiring extensive hemodynamic support. She had abnormal electrocardiogram. was diagnosed severe that initially responded to intracoronary nitroglycerin. However, course complicated by arrhythmias and cardiogenic shock following additional episode required higher concentrations Notably, this...
Abstract There is overwhelming clinical evidence that the extracellular-regulated protein kinase 5 (ERK5) significantly dysregulated in human breast cancer. However, there no definite understanding of requirement ERK5 tumor growth and metastasis due to very limited characterization pathway disease models. In this study, we report a high level predictive marker metastatic Mechanistically, our vitro data revealed was critical for maintaining invasive capability triple-negative cancer (TNBC)...
Abstract Background Dissecting intramural hematoma is a rare complication of acute myocardial infarction (AMI) and has been associated with increased mortality. There paucity literature to establish protocols guidelines for management in such cases. Case presentation We hereby report the case 45-year-old male patient left ventricular dissecting (LV-IDH) who presented chest pain breathlessness diagnosed as non-ST-elevation (NSTEMI). Transthoracic echocardiography (TTE) was performed showing...
The monarchE study added the CDK4/6 inhibitor abemaciclib to care of women with oestrogen-positive (ER+) breast cancers. Eligibility required meeting criteria—either >3 positive axillary nodes, or 1–3 sentinel nodes (SNB+) tumour size >50 mm grade 3 Women were advised proceed completion node clearance (cANC) if size/grade criteria not fulfilled for be identified. However, cANC is associated significant morbidity, conflicting potential benefits abemaciclib. We analysed data 229...
Targeting HER2 has become a landmark in the treatment of HER2-driven breast cancer. Nonetheless, clinical efficacy anti-HER2 therapies can be short-lived and significant proportion patients ultimately develop metastatic disease die. One striking consequence oncogenic activation cancer cells is constitutive extracellular-regulated protein kinase 5 (ERK5) through its hyperphosphorylation. In this study, we sought to decipher significance unique molecular signature promoting therapeutic...
Abstract Breast cancer remains a leading cause of mortality, predominantly due to the development metastases vital organs. At present, predictive biomarkers organ specific metastasis and therapies targeted metastatic niche are limited. Here, identify molecular determinants breast we analysed patient-derived tumours by combining quantitative proteomics, bioinformatics, functional assays in vitro vivo. We identified elevated levels protein Osteomodulin (OMD) associated with bone samples. OMD...
Cutaneous manifestations are interesting presentations of COVID-19 infection, but only a few cases have described the histological findings skin biopsy in these patients. We present case positive patient with morbilliform rash whose showed presence fibrin microthrombi within small vessels as main distinctive histologic feature.
Coronavirus disease 2019 (COVID-19) is an evolving situation worldwide, which associated with a broad range of symptoms from pneumonia/acute respiratory distress syndrome (ARDS) to multiorgan failure. So far, we have also encountered several patients coagulopathy, including pulmonary embolism and deep vein thrombosis. A few cases limb ischemia related COVID-19 been reported as well, but most them involve critically ill patients. In this report, discuss case in patient who presented right...
Cardiogenic shock is a significant economic burden on healthcare facilities and patients. The prevalence outcome of cardiogenic in the South Bronx are unknown. aim study was to examine non-AMI CS Hispanic Black population characterize their in-hospital outcomes. We reviewed patient charts between 1/1/2022 1/1/2023 identify patients with primary diagnosis (ICD codes R57.0, R57, R57.8, R57.9) residing following zip codes: 10451-59 10463. Student's T-test used assess differences for continuous...
Hyperkalemia is one of the most common electrolyte abnormalities seen in clinical practice and life-threatening abnormality emergency department. It often due to impaired renal potassium excretion acute on chronic kidney disease or use drugs that inhibit renin-angiotensin-aldosterone axis. The presentation muscle weakness cardiac conduction abnormalities. In Emergency Department, ECG can come handy as first diagnosis hyperkalemia before labs are drawn reported. Early recognition...
Sphincter of Oddi dysfunction (SOD) is a syndrome caused by either dyskinesia or stenosis the sphincter Oddi. It has been categorized into biliary and pancreatic SOD based on clinical features laboratory findings. We present case 51-year-old female (post-cholecystectomy) who presented with intermittent chronic right upper quadrant pain. Laboratory investigations showed persistently elevated liver function tests dilated common bile duct without presence any stones. Endoscopic retrograde...
Oxaliplatin is one of the most common anti-neoplastic agents used in treatment small bowel adenocarcinoma. Peripheral neuropathy side effects oxaliplatin. Oxaliplatin-induced thrombocytopenia an extremely rare effect and can result from various mechanisms. We present a case 66-year-old female who presented to hospital for ninth cycle FOLFOX chemotherapy her The patient developed severe within 24 hours administration Physicians need be aware sudden onset associated with oxaliplatin use as...
Atypical hemolytic uremic syndrome (HUS) is a rare but severe form of thrombotic microangiopathies (TMAs) that affects both children and adults. The clinical presentation usually nonspecific, including broad spectrum symptoms ranging from abdominal pain, confusion, diarrhea, fatigue, irritability, hypertension, lethargy. We present case 36-year-old woman with medical comorbidities asthma pulmonary embolism who presented to our hospital in the 36th week her pregnancy for preterm premature...
Acute compartment syndrome develops when intracompartmental pressure increases either due to intrinsic or extrinsic causes. Increase in eventually can lead impaired tissue perfusion followed by death if no urgent intervention is performed. Patients with acute usually present pain out of proportion apparent injury. It cause rhabdomyolysis, myoglobinuria, and renal failure. The definite treatment fasciotomy a timely manner. We here report very interesting case young patient over his axilla an iPad.
<div><p>Targeting HER2 has become a landmark in the treatment of HER2-driven breast cancer. Nonetheless, clinical efficacy anti-HER2 therapies can be short-lived and significant proportion patients ultimately develop metastatic disease die. One striking consequence oncogenic activation cancer cells is constitutive extracellular-regulated protein kinase 5 (ERK5) through its hyperphosphorylation. In this study, we sought to decipher significance unique molecular signature promoting...
<p>These data support the conclusion that ERK5 inhibtion enhances cytostatic activity of lapatinib in resistance cells without increasing cytotoxicity.</p>
<p>AX-15836 and BIX-02189 reproduce the inhibitory effect of JWG-045 on level phospho-RB MDA-MB-361 cell density.</p>
<p>JWG-045 enhances the sensitivity of HER2+ breast cancer cells to trastuzumab through decreasing proportion in S phase, rather than increasing apoptotic cell death.</p>
<p>The effect of lapatinib and JWG-045 as single treatments was compared to that achieved in combination therapy on the cell cycle profile sensitive resistant breast cancer lines.</p>
<p>Lapatinib treatment inhibits tyrosine phosphorylation of HER1/2/3 in both sensitive and resistant breast cancer cells.</p>