A5006788177- Plant chemical constituents analysis
- Synthesis of Organic Compounds
- Food Quality and Safety Studies
- Chemical Synthesis and Analysis
- Synthesis and Biological Activity
- Advanced Synthetic Organic Chemistry
- Synthesis and Catalytic Reactions
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Phytochemistry and Biological Activities
- Chemical Reactions and Isotopes
- Steroid Chemistry and Biochemistry
- Chemokine receptors and signaling
- Crystallization and Solubility Studies
- Medicinal Plant Extracts Effects
- Neuroscience and Neuropharmacology Research
- Sesquiterpenes and Asteraceae Studies
- Oxidative Organic Chemistry Reactions
- Cancer therapeutics and mechanisms
- Chemical synthesis and alkaloids
- Sphingolipid Metabolism and Signaling
- Essential Oils and Antimicrobial Activity
Indian Institute of Technology Madras
2011-2023
New York University Abu Dhabi
2022
University of Minnesota
2015-2017
The Hooker oxidation is one of the most intriguing transformations wherein lapachol (1) readily converted to norlapachol (2) in very good yield. This one-pot reaction involves a intricate mechanism which alkyl side chain shortened by carbon unit. Previous studies have unequivocally established involvement an indane carboxylic acid derivative 3, as key intermediate (Hooker intermediate), and its simultaneous conversion via oxidative cleavage vicinol diol subsequent intramolecular aldol...
Abstract An efficient one‐pot synthesis of sterically hindered aromatic tertiary amines through Lewis acid induced intermolecular Schmidt reaction benzylic azides is described. In the presence EtAlCl 2 , azide underwent a smooth to give corresponding iminium ion, which, upon reduction with NaBH 4 in situ, afforded amine. The effects substituents on ring and steric alkyl side chain have also been studied.
A TiCl4-promoted domino semipinacol–Schmidt reaction of oxaspiropentane-azide provides an easy access to bridged azatricyclic ring systems, which possess the azaquaternary center, present in immunosupressant FR901483 and platelet aggregation inhibitor daphlongeranine B.
Abstract We showed previously that daily gavage of Angelica gigas Nakai (AGN) root ethanolic extract starting 8 weeks age inhibited growth prostate epithelium and neuroendocrine carcinomas (NE-Ca) in the transgenic adenocarcinoma mouse (TRAMP) model. Because decursin (D) its isomer decursinol angelate (DA) are major pyranocoumarins AGN extract, we tested hypothesis D/DA represented active/prodrug compounds against TRAMP carcinogenesis. Three groups male C57BL/6 mice were treated with...
We have previously shown that the ethanol extract of dried Angelica gigas Nakai (AGN) root exerts anticancer activity against androgen receptor (AR)-negative human DU145 and PC-3 prostate cancer xenografts primary carcinogenesis in transgenic adenocarcinoma mouse (TRAMP) model. The major pyranocoumarin isomers decursin (D) decursinol angelate (DA), when provided at equi-molar intake to by AGN extract, accounted for inhibitory efficacy precancerous epithelial lesions TRAMP mice. Since we...
(+)-Dihydromethysticin was recently identified as a promising lung cancer chemopreventive agent, while (+)-dihydrokavain completely ineffective. A pilot in vivo structure–activity relationship (SAR) explored, evaluating the efficacy of its analogs blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced short-term O6-methylguanine and long-term adenoma formation tissues A/J mice. Both results revealed cohesive SARs, demonstrating that methylenedioxy functional group DHM is essential...
Precise photochemical control, using two-photon excitation (2PE), of the timing and location activation glutamate is useful for studying molecular cellular physiology brain. Antenna-based light harvesting strategies represent a general method to increase sensitivity 2PE otherwise insensitive photoremovable protecting groups (PPGs). This was applied most commonly used form "caged" glutamate, MNI-Glu. Computational investigation showed that four- or six-carbon linker attached between...
Abstract Prostate cancer is a malignant disease quite unique to men and has the second highest mortality rate next lung in United States, with an estimated 233,000 new cases be diagnosed 2014. Angelica gigas Nakai (AGN) traditional medicinal herb Korea China. Ethanol extract of dried AGN root been shown by us others exert anti-cancer activity several allograft xenograft models. In recently completed studies primary carcinogenesis model (TRAMP mice), our group demonstrated that ethanol can...
Abstract A concise approach has been developed for the diastereoselective synthesis of azatricyclic core (−)‐7 a‐ epi ‐lepadiformine ( 8 a ) and C b using stereoselective domino semipinacol‐Schmidt reaction as key step. In presence TiCl 4 , oxaspiropentane‐azide derivatives underwent cyclization to furnish corresponding angularly fused cores in very good yields. Moreover, also realized, stepwise manner, through intramolecular Schmidt azido‐spirocyclobutanone intermediate. The synthetic...
<p>TRAMP prostate epithelial lesion scoring guide.</p>
<p>Effect of daily gavage AGN or D/DA on weights prostate lobes in TRAMP mice vs. wild type.</p>
<p>qRT-PCR primer sequences.</p>
<p>Hematoxylin and eosin (H&E) immuno-histochemical characterization of epithelial lesions, NE-Ca metastatic lymph nodes.</p>
<p>TRAMP prostate epithelial lesion scoring guide.</p>
<p>qRT-PCR primer sequences.</p>
<p>Hematoxylin and eosin (H&E) immuno-histochemical characterization of epithelial lesions, NE-Ca metastatic lymph nodes.</p>
<p>Effect of daily gavage AGN or D/DA on weights prostate lobes in TRAMP mice vs. wild type.</p>
<div>Abstract<p>We showed previously that daily gavage of <i>Angelica gigas</i> Nakai (AGN) root ethanolic extract starting 8 weeks age inhibited growth prostate epithelium and neuroendocrine carcinomas (NE-Ca) in the transgenic adenocarcinoma mouse (TRAMP) model. Because decursin (D) its isomer decursinol angelate (DA) are major pyranocoumarins AGN extract, we tested hypothesis D/DA represented active/prodrug compounds against TRAMP carcinogenesis. Three groups male...
The Cover Feature represents the power of a domino semi-pinacol-Schmidt reaction in synthesis biologically relevant molecules, bearing aza-tricyclic core. flow water from mountain is natural and proceeds on its own without any visible external force. Likewise, spontaneous, efficient, downhill process, which leads to final product with high degree stereoselectivity through series reactions one pot. In this art, each fall formation interconversion intermediate that spontaneously participates...
<div>Abstract<p>We showed previously that daily gavage of <i>Angelica gigas</i> Nakai (AGN) root ethanolic extract starting 8 weeks age inhibited growth prostate epithelium and neuroendocrine carcinomas (NE-Ca) in the transgenic adenocarcinoma mouse (TRAMP) model. Because decursin (D) its isomer decursinol angelate (DA) are major pyranocoumarins AGN extract, we tested hypothesis D/DA represented active/prodrug compounds against TRAMP carcinogenesis. Three groups male...
Abstract If an enantiomerically enriched compound (I) is used as starting material, the reaction proceeds with preservation of stereochemical information.