A5043713844- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Galectins and Cancer Biology
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Mechanisms of cancer metastasis
- IL-33, ST2, and ILC Pathways
- Lipid metabolism and disorders
- Lymphatic System and Diseases
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Cancer Risks and Factors
- Brain Metastases and Treatment
- Microbial metabolism and enzyme function
Shandong First Medical University
2019-2025
Shandong Tumor Hospital
2021-2025
Shandong University
2012-2024
Jinan Central Hospital
2012-2022
Saint Louis University
2018-2021
The functional state of T cells is a key determinant for effective antitumor immunity and immunotherapy. Cellular metabolism, including lipid controls cell differentiation, survival, effector functions. Here, we report that development senescence driven by both malignant tumor regulatory general feature in cancers. Senescent have active glucose metabolism but exhibit unbalanced metabolism. This results changes expression metabolic enzymes, which, turn, alters species accumulation droplets...
Rationale: Immune checkpoint inhibitors (ICIs) against the PD-1/PD-L1 pathway showed limited success in non-small cell lung cancer (NSCLC) patients, especially those with activating epidermal growth factor receptor (EGFR) mutations. Elucidation of mechanisms underlying EGFR-mediated tumor immune escape and development effective therapeutics are urgently needed. Immunoglobulin-like transcript (ILT) 4, a crucial immunosuppressive molecule initially identified myeloid cells, is enriched solid...
Tumor-infiltrating immune cells (TICs) are highly relevant to tumor development and promising prognostic biomarkers. However, the precise assessment of TICs is limited by deficiencies traditional measurements, such as lack phenotypic markers. Here, we analyzed composition in cervical cancer based on RNA expression data with a metagene approach called CIBERSORT evaluated value TICs. The infiltration profiles functioned intrinsic features distinguish from normal tissue. According Cox...
Background Current immunotherapies including checkpoint blockade therapy have limited success rates in certain types of cancers. Identification alternative molecules for the development effective strategies tumor immunotherapy is urgently needed. Immunoglobulin-like transcript 4 (ILT4) an immunosuppressive molecule expressed both myeloid innate cells and malignant cells. However, role tumor-derived ILT4 regulating cancer biology immunity remains unclear. Methods expression patient samples...
Immunoglobulin‐like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 over‐expressed in human non‐small cell lung cancer (NSCLC) cells and involved tumour evasion via an unknown mechanism. In this report, we demonstrate increases expression co‐inhibitory molecule B7‐H3 through PI3K/AKT/mTOR signalling. primary NSCLC tissues, a significant positive relationship observed between expression. ILT4/B7‐H3 co‐expression...
Abstract Metabolic disorder is one of the hallmarks cancers, and reprogramming metabolism becoming a novel strategy for cancer treatment. Citrate key metabolite critical metabolic regulator linking glycolysis lipid in cellular energy homeostasis. Here it reported that citrate treatment (both sodium citric acid) significantly suppresses tumor cell proliferation growth various types. Mechanistically, promotes excessive biosynthesis induces disruption cells, resulting senescence inhibition....
Aberrant tumor cell expression of B7-H3, a member the B7-family that stimulates interleukin-10 (IL-10) secretion, contributes to immune evasion and progression. The aim this study was investigate B7-H3 IL-10 in ductal lobular breast cancer tissues. Using immunohistochemistry, protein specimens primary human investigated. association between or clinicopathological variables analyzed. correlation also evaluated. In tissues, identified on membrane cytoplasm. Expression observed 90.60% (106/117)...
Abstract Immunochemotherapy combinations have been the standard first‐line therapy for advanced lung adenocarcinoma (LUAD) without driver mutations, wherein concurrent chemotherapy and immunotherapy are conventionally anchored in established dosing regimen. A few studies suggested that timing of may a significant impact on efficacy. However, this issue has not addressed an LUAD cohort. We aimed to investigate prognostic significance immunochemotherapy patients with LUAD. retrospectively...
Abstract Antiangiogenic therapy targeting VEGF‐A has become the standard of first‐line for non‐small cell lung cancer (NSCLC). However, its clinical response rate is still less than 50%, and most patients eventually develop resistance, even when using combination with chemotherapy. The major cause resistance activation complex bypass signals that induce angiogenesis tumor progression. Therefore, exploring novel proangiogenic mechanisms developing promising targets are crucial improving...
8014 Background: The phase 3 trial (CAPSTONE-1) showed that adebrelimab (PD-L1 antibody) combined with first-line chemotherapy could prolong overall survival (OS) in patients (pts) extensive-stage small cell lung cancer (ES-SCLC). Previous studies have shown radiotherapy can enhance the immunogenicity of tumors, indicating great potential combining immunotherapy. purpose this study was to explore efficacy and safety sequential thoracic (TRT) as therapy for ES-SCLC. Methods: Key inclusion...
Cancer associated fibroblasts (CAFs) are a crucial cellular component in tumor microenvironment and could promote progression. CAFs usually derived from resident fibroblasts, which undergoing an activated process stimulated by cells. However, the agents mechanism driving this switch have not yet been elucidated. Progranulin (PGRN), well acknowledged secreted glycoprotein, proliferation angiogenesis of colorectal cancer (CRC) cells, high expression PGRN correlated with patient poor prognosis....
The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed myeloid innate cells. Recent studies showed that ILT4 was highly multiple malignant cells and regulated tumor biologies including proliferation, invasion metastasis. However, the immunomodulatory role cell-derived unclear. Here we aimed analyze correlation cell expression with T...
Infiltration of immunosuppressive cells in the tumor microenvironment (TME) induced colorectal cancer (CRC) progression and its resistance to immunotherapy. Identification tumor-specific factors modulate inhibitory immunocyte infiltration would provide alternative novel targets for CRC Immunoglobulin-like transcript (ILT) 5 is a negative regulator myeloid cell activation. However, expression functional role solid tumors still unknown. Using human tissues lines, we found that ILT5 was highly...
Abstract Increasing evidence indicates that human forkhead box C1 (FOXC1) plays important roles in tumor development and metastasis. However, the underlying molecular mechanism of FOXC1 non–small cell lung cancer (NSCLC) metastasis remains unclear. Here, we identified as an independent prognostic factor NSCLC showed clear biological implications invasion overexpression enhanced proliferation, migration cells, whereas silencing impaired effects both vitro vivo. Importantly, found a positive...