A5045039849- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Proteomics Techniques and Applications
- Species Distribution and Climate Change
- Advanced Chemical Sensor Technologies
- Pain Mechanisms and Treatments
- Genomics and Phylogenetic Studies
- 3D Printing in Biomedical Research
- Mitochondrial Function and Pathology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- DNA and Nucleic Acid Chemistry
- Paleontology and Evolutionary Biology
- Analytical chemistry methods development
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Wildlife-Road Interactions and Conservation
- Scarabaeidae Beetle Taxonomy and Biogeography
- Amino Acid Enzymes and Metabolism
- Biomedical Text Mining and Ontologies
- Muscle metabolism and nutrition
Saint Louis University
2014-2024
UCLouvain Saint-Louis Brussels
2015-2023
WakeMed
2022
Nuffield Orthopaedic Centre
2022
University of Oxford
2022
Saint Louis University
2019
Janssen (United States)
2019
University of Maryland, College Park
2011-2013
Institute for Bioscience and Biotechnology Research
2011-2013
Advanced Bioscience Laboratories (United States)
2011-2013
Data about biodiversity are either scattered in many databases or reside on paper other media not amenable to interactive searching. The Global Biodiversity Information Facility (GBIF) is a framework for facilitating the digitization of data and making interoperable an as-yet-unknown number that distributed around globe. In concert with existing efforts, GBIF will catalyze completion Catalog Names Known Organisms develop search engines mine vast quantities data. It be outstanding tool...
Metabolites in islets of Langerhans and Escherichia coli strain DH5-alpha were analyzed using negative-mode, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). For analysis anionic metabolites by MALDI, 9-aminoacridine as the matrix yielded a far superior signal comparison to alpha-cyano-4-hydroxycinnamic acid, 2,5-dihydrobenzoic 2,4,6,-trihydroxyacetophenone, 3-hydroxypicolinic acid. Limits detection for metabolite standards low 15 nM GDP, GTP, ADP,...
The basis of all comparative biology is the determination phylogenetic relationships and lineages. most difficult question in lineage whether similarity between two forms result monophyly, parallel evolution, or convergent evolution. erection a new phylogeny testing previously proposed grouping involves several steps: (1) relation characters their homologous character states-the morphocline; (2) within morphocline its primitive derived states polarities; (3) evaluation by means weighting...
Intracellular amine metabolite changes were quantified from hyperglycemic human aortic endothelial cells (HAECs) as a model for macrovascular complications of diabetes. Amines selectively tagged using the N-hydroxysuccinimide ester (NHS) based isobaric tag DiART (Deuterium Amine Reactive Tag), synthesized in house. labeling improved chromatographic resolution derivatized amines, resulted 100-fold signal-to-noise enhancement mass spectrometry (MS) analyses, and allowed multiplex...
Glycans play significant roles in physiological and pathological processes. Therefore, quantitative analysis of glycans from normal disease specimens can provide insight into onset progression. Relative glycan quantification usually requires modification the with either chromogenic or fluorogenic tags for optical measurement isotopic mass spectrometric analysis. Because rapid advances spectrometry (MS) instruments resolution, sensitivity, speed, MS-based methods have become increasingly...
Abstract Examination of the vertebral columns representatives all families salamanders revealed that, in contrast to condition found most other vertebrates, salamander spinal nerves often pass through foramina vertebrae. Two kinds nerve were found: those anterior halves vertebrae, and posterior halves. In addition, many retain intervertebral nerves. However, within each family or, a few cases, subfamily there is characteristic pattern nerve‐vertebral relationships. The first exits foramen...
Chromosomal DNA replication requires the spatial and temporal coordination of activities several complexes that constitute replisome. A previously uncharacterized protein, encoded by TK1252 in archaeon Thermococcus kodakaraensis, was shown to stably interact with archaeal GINS complex vivo, a central component Here, we document this protein (TK1252p) is processive, single-strand DNA-specific exonuclease degrades 5′ → 3′ direction. TK1252p binds specifically GINS15 subunit T. kodakaraensis...
Isobaric tags have broad applications in both basic and translational research, as demonstrated by the widely used isobaric tag for relative absolute quantitation (iTRAQ). Recent results from large-scale quantitative proteomics projects, however, indicate that protein quantification iTRAQ is often biased complex biological samples. Here, we report application of another tag, deuterium amine reactive (DiART), quantifying proteome Thermoanaerobacter tengcongensis (T. tengcongensis), a...
SYNOPSIS. The evolution of the tetrapod limb is examined from two perspectives: structural and functional. Rosen et al. (1981) argued that lungfishes are sister group tetrapods, with characteristics comprising an important subset their evidence. A re-analysis characters advocated by does not support contention, but instead suggests rhipidistian fishes family Osteolepidae closest relatives tetrapods. In order to understand probable selective pressures leading limb, a functional analysis fins...