A5101817015- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Advanced Glycation End Products research
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Congenital gastrointestinal and neural anomalies
- Vagus Nerve Stimulation Research
- Gastroesophageal reflux and treatments
- Pelvic floor disorders treatments
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- Digestive system and related health
- Acupuncture Treatment Research Studies
- Phagocytosis and Immune Regulation
- Sphingolipid Metabolism and Signaling
- Inflammasome and immune disorders
- Synthesis of Organic Compounds
- Antibiotic Resistance in Bacteria
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Chemotherapy-induced organ toxicity mitigation
University of Michigan
2025
Wuxi No.2 People's Hospital
2013-2024
Jiangnan University
2023-2024
State Key Laboratory of Food Science and Technology
2023
Nanjing Medical University
2015-2021
Wuxi People's Hospital
2020-2021
Xian Yang Central Hospital
2021
University of Benin
2016
University Gastroenterology
2016
Texas A&M University
2007
Increasing researches have confirmed the relationship between slow-transit constipation and gut microbiota dysbiosis. Many population animal experiments identified probiotics as effectors for relief of symptoms, but specific mechanism remains unclear. In this intervention study, Lactobacillus rhamnosus strains isolated from five different sources were administered to mice with loperamide-induced constipation, impacts these on constipation-related indicators evaluated. All L. found improve...
TNF-related apoptosis-inducing ligand (TRAIL) functions as a selective in cancer cells with normal remaining unaffected; however, resistance limits its anticancer properties. Cancer stem (CSCs) are involved the treatment of resistant cases including liver (LC). The aim this study was to look into approaches for increasing sensitivity (LCSCs) toward TRAIL.PLC, HepG2 and Huh7 LC cell lines were used study. Quantitative reverse transcription PCR (qRT-PCR) analysis done evaluating expression...
BackgroundNonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH. Pyroptosis mediated by inflammasome activation pathways caspase-1–mediated canonical signaling pathway caspase-11–mediated noncanonical pathway. Until now, the precise role caspase-11 NASH remains unknown. In present study, potential roles were explored.MethodsWe established methionine-...
Constipation is a major health concern worldwide and requires effective safe treatment options. In this study, we selected ten strains of two species lactobacilli to identify whether they were against constipation induced by loperamide administration in BALB/c mice. Monitoring constipation-related indicators indicated that Lactobacillus paracasei (L. paracasei) mainly acted on the whole intestinal peristalsis relieve constipation. Furthermore, through detection biological, chemical,...
Gastric dysmotility and gastric slow wave dysrhythmias have been well documented in patients with diabetes. However, little is known on the effect of hyperglycemia small intestine motility, such as intestinal waves, due to limited options measuring its activity. Moreover, food intake digestion process reported alter motility normal rats, but their roles that diabetic rats remains unknown. This study aimed explore myoelectrical activity (IMA) responses various meals rats. IMA was recorded via...
The abnormalities of gastrointestinal (GI) slow waves play key roles in the pathophysiology diabetic gastroparesis that is highly prevent type 2 diabetes (T2D). While relatively well-investigated enteric neuropathy, and progressive impairments gastric (GSW) duodenal (DSW) are under-investigated during progression T2D. aim this study was to explore alterations GSW DSW development induced by high fat diet (HFD) followed with a low dose streptozotocin (STZ). Weekly recordings from healthy,...
Klebsiella pneumoniae (K. pneumoniae, KP) are divided into two types: classic K. (cKP) and hypervirulent (hvKP). hvKP causes liver abscess metastatic infection. Here, we report one case with pyogenic (PLA) endogenous endophthalmitis (EE) due to a relatively rarely reported serotype of in China.An 80-year old man presented nausea, vomiting, epigastric discomfort for 2 weeks.PLA was identified by CT scan abdominal ultrasound. Urgent ophthalmologic consultation performed. B-scan ocular...
To investigate the characteristics of high-resolution anorectal manometry (HR-ARM) in Parkinson disease (PD) patients with defecation disorder (DD) compared functional (FDD).DD is a common gastrointestinal symptom PD. HR-ARM relatively new and reliable method for detecting DD.A cohort PD DD was matched FDD patients. Defecatory symptoms were investigated by questionnaire. Anorectal motility sensation evaluated HR-ARM. Differences defecatory symptoms, sensorimotor parameters, type analyzed....
Phospholipid scramblase 1 (PLSCR1) serves a function in the pathogenesis and progression of various types cancer. However, role PLSCR1 human primary liver cancer remains unknown. The aim present study was to evaluate expression analyse clinical significance. In addition, detected compared biological behaviours HepG2 cells with different levels activated or silenced PLSCR1. tissue samples examined using immunohistochemistry. Cultured were infected lentiviruses suppress activate expression....
Purpose: To evaluate the effect of bryostatin I on proliferation pancreatic cancer cells as well tumor growth in mice xenograft model.Methods: Activation NF-κB was evaluated by preparing nuclear material extract using kit (Carlsbad, CA, USA) followed enzyme-linked immunosorbent assay (ELISA). Mice were injected with 3 x 105 MIApaCa 2 100 μL volume PBS. The animals treatment group 50 μg/kg 1 daily for month morning whereas those untreated received an equal normal saline.Results: Treatment...