A5048647544- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Pluripotent Stem Cells Research
- Dental Implant Techniques and Outcomes
- Polyoxometalates: Synthesis and Applications
- Genetic Neurodegenerative Diseases
- Osteoarthritis Treatment and Mechanisms
- Biomedical Ethics and Regulation
- Enzyme Structure and Function
- Orthopaedic implants and arthroplasty
- Advanced Nanomaterials in Catalysis
- Supramolecular Chemistry and Complexes
- Aldose Reductase and Taurine
- Dental Radiography and Imaging
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Magnetism in coordination complexes
- Immunodeficiency and Autoimmune Disorders
- Electrochemical Analysis and Applications
- Esophageal and GI Pathology
- Autoimmune Neurological Disorders and Treatments
- Nanocluster Synthesis and Applications
Qilu Hospital of Shandong University
2020-2025
Stomatology Hospital
2009-2024
Zhejiang University
2009-2024
East China University of Science and Technology
2024
Shanghai Eighth People Hospital
2024
Xi’an University
2015-2022
First Hospital of Shanxi Medical University
2020
Shanxi Medical University
2020
Donghua University
2019
Shenyang Institute of Engineering
2012
Cysteine dioxygenase is a non-heme mononuclear iron metalloenzyme that catalyzes the oxidation of cysteine to sulfinic acid with addition molecular dioxygen. This irreversible oxidative catabolism initiates several important metabolic pathways related diverse sulfurate compounds. therefore very for maintaining proper hepatic concentration intracellular free cysteine. Mechanisms mouse and rat dioxygenases have recently been reported based on their crystal structures in absence substrates,...
To evaluate the outcomes of an apically repositioned flap (ARF) plus xenogeneic collagen matrix (XCM) in augmenting keratinized mucosa width (KMW) around dental implants when compared with ARF free gingival grafts (FGG).Twenty-six participants at least one site KMW ≤2 mm were randomized into FGG or XCM group. Clinical examinations performed baseline and 2 6 months after surgery, including KMW, thickness, index (GI), probing depth (PD). Post-operative pain patient satisfaction also...
This study aimed to compare the effects of bone morphogenetic protein BMP2/7 heterodimer and BMP homodimers on regeneration in defects model. Identical peri-implant model were created using proper controls frontal skull 18 minipigs. Collagen sponges with low-dose (30 ng/mL) heterodimer, BMP2 or BMP7 homodimer filled defects. New formation expression type I collagen (Col1), alkaline phosphatase (ALP) osteocalcin (OCN) evaluated after 2, 3, 6 weeks implantation. resulted significantly higher...
In the repair of large segmental bone defects, tissue is often unable to heal due destruction vascular network near wound site. An ideal material should have both angiogenic and osteogenic capabilities. To achieve this goal, we used biodegradable mesoporous silica nanoparticles (MSNs) as a delivery vehicle for dexamethasone (DEX), small-molecule drug that induces differentiation. Subsequently, chitosan was covalently modified onto surface by glycidoxypropyltrimethoxysilane (GPTMS) construct...
Abnormal trinucleotide CAG repeat expansions in exon 10 of the ataxin-3 (ATXN3) gene has been identified as cause Spinocerebellar Ataxia Type 3 (SCA3). We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts patient with genetically confirmed SCA3. The pluripotency these iPSCs was verified by expression several undifferentiated hPSCs markers at both RNA protein levels, well their capability to differentiate into all three germ layers.
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of nerve cells in the spinal cord and brain. We generated human induced pluripotent stem cell (iPSC) line from skin fibroblasts patient with ALS due to SOD1 Mutation. The pluripotency these iPSCs was verified expression several markers at both RNA protein levels, as well their capability differentiate into all three germ layers.
Heterodimeric bone morphogenetic proteins (BMPs) were exhibited to be more potent than and thus potential substitutes for homodimeric BMPs whose clinical application is limited the drawbacks resulted from their higher effective doses. This study aims delineate biofunctional characteristics of recombinant human BMP2/7 (rhBMP2/7) heterodimer in inducing osteoblastogenesis MC3T3-E1 through vitro time–course dose–response studies. rhBMP2/7 induced cell migration with a significantly lower...
Three Schiff base ligands containing two pyridine rings, S1, S2, and S3, show strong gelation abilities with AgNO3 in several pure or mixed solvents at room temperature. 1H NMR Fourier transform infrared spectroscopy measurements not only demonstrated the coordination interaction between silver ion nitrogen atom of ring S2 ligand S2-Ag metallogel, but also showed that hydrogen bonding contributes to formation metallogels. In particular, metallogel shows a super smart fully reversible...
Background Women with congenital heart disease are considered at high risk for adverse events. Therefore, we aim to establish 2 prediction models mothers and their offspring, which can predict the of events occurred in pregnant women disease. Methods Results A total 318 were included; 213 divided into development cohort, 105 validation cohort. Least absolute shrinkage selection operator was used predictor selection. After validation, multivariate logistic regression analysis develop model....
Large-volume bone defects can result from congenital malformation, trauma, infection, inflammation and cancer. At present, it remains challenging to treat these with clinically available interventions. Allografts, xenografts most synthetic materials have no intrinsic osteoinductivity, so an alternative approach is functionalize the biomaterial osteoinductive agents, such as morphogenetic protein 2 (BMP2). Because has been previously demonstrated that human salivary histatin-1 (Hst1) promotes...
This study identified potential general influencing factors for a mathematical prediction of implant stability quotient (ISQ) values in clinical practice.We collected the ISQ 557 implants from 2 different brands (SICace and Osstem) placed by surgeons 336 patients. Surgeon 1 329 SICace implants, surgeon 113 115 Osstem implants. measurements were taken at T1 (immediately after placement) T2 (before dental restoration). A multivariate linear regression model was used to analyze influence...
A 2-D coordination polymer with mixed ligands, [Zn2(BDC)(4,4′-bipy) (HCOO)2] (1) (BDC, 1,4-benzenedicarboxylate; 4,4′-bipy, 4,4′-bipyridine), has been synthesized by solvothermal reaction. Compound 1 provides the first structure constructed bridging BDC, and formate. Both BDC 4,4′-bipy link zincs alternatively, resulting in a zigzag chain; adjacent chains are further linked formates to form an infinite extended folding screen layer. The synthesis mechanism fluorescence property discussed.
The development, progression, and curative efficacy of head neck squamous cell carcinoma (HNSCC) are influenced by complex interactions between epithelial immune cells. Nevertheless, the specific changes in nature these their underlying molecular mechanisms HNSCC not yet fully understood. Cuproptosis, a form programmed death that is dependent on copper, has been implicated cancer pathogenesis. However, understanding cuproptosis context remains limited. In this study, we have discovered...
Promoting cell spreading is crucial to enhance bone healing and implant osteointegration. In this study, we investigated the stimulatory effect of human salivary histatin-1 (Hst-1) on osteogenic cells in vitro as well potential signaling pathways involved. Osteogenic were seeded bio-inert glass slides with or without presence Hst1 dose-dependent time-course assays. 1 scrambled 6 truncated variants also evaluated. Cell was analyzed using a well-established point-counting method. Fluorescent...
The avascular structure and lack of regenerative cells make the repair osteochondral defects in temporomandibular joint (TMJ) highly challenging clinic. To provide a viable treatment option, we developed methacrylated gelatin (Gel-MA) hydrogel functionalized with human salivary histatin-1 (Hst1). Gel-MA is biocompatible, biodegradable, cost-effective. Hst1 capable activating series cell activities, such as adhesion, migration, differentiation, angiogenesis. evaluate efficacy Hst1/Gel-MA,...
Abstract A metal‐organic coordination polymer formulated as (H 3 O) 2 [Zn(BTEC)] ( 1 ), where BTEC = 1,2,4,5‐benzenetetracarboxylate, was synthesized by solvothermal reaction and characterized elemental analyses, thermal stability analysis, fluorescence IR spectroscopy, well single‐crystal X‐ray diffraction analysis. Compound is a three‐dimensional network containing one‐dimensional rhombic channels, the sizes of windows are approximately 8 Å at widest 4.5 narrowest spacing (excluding van...
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