A5100356396- Cervical Cancer and HPV Research
- Autophagy in Disease and Therapy
- Photodynamic Therapy Research Studies
- Molecular Biology Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Olfactory and Sensory Function Studies
- Spaceflight effects on biology
- Mycobacterium research and diagnosis
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Vascular Tumors and Angiosarcomas
- Autopsy Techniques and Outcomes
- Alcohol Consumption and Health Effects
- Palliative Care and End-of-Life Issues
- Endometriosis Research and Treatment
- RNA modifications and cancer
- Biochemical Analysis and Sensing Techniques
- Calcium signaling and nucleotide metabolism
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Tuberous Sclerosis Complex Research
- Viral-associated cancers and disorders
- High Altitude and Hypoxia
Minzu University of China
2019-2024
Qilu Hospital of Shandong University
2022-2024
China Medical University
2011-2022
First Hospital of China Medical University
2022
Shandong University
2022
Lanzhou University
2022
First Hospital of Lanzhou University
2022
Duke Medical Center
2018
Duke University
2018
Binzhou People's Hospital
2017
5-Aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) is a possible minimally-invasive treatment for high-grade cervical intraepithelial neoplasia (HSIL). The present study was carried out to assess the effect of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in squamous (CIN2) combined with high-risk human papillomavirus (HR-HPV) infection. In this study, 190 patients CIN2 HR-HPV infection were finally included. They divided into LEEP Group (n=116) PDT (n=74)...
High-altitude cerebral edema (HACE) is a severe neurological condition that can occur at high altitudes. It characterized by the accumulation of fluid in brain, leading to range symptoms, including headache, confusion, loss coordination, and even coma death. Exosomes play crucial role intercellular communication, their contents have been found change various diseases. This study analyzed metabolomic characteristics blood exosomes from HACE patients compared those healthy controls (HCs) with...
Inhibition of Bcl2 family proteins Bcl-XL and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cells. Here we report novel inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported inhibitors that induce death mainly through apoptosis, makes an attractive molecular tool studying the cellular regulation
Objective: To investigate the morphological and structural changes of oral mucosa under influence alcohol.Methods: Sixty male female specimens (42 males 18 females) who died chronic alcoholism were selected in this study. The (5-7 mm) sliced by morphological-histological detection method, stained HE Spielmeyer (myelin staining) protocols respectively. Then five immune peroxidase chemical reaction tests performed.Results: 10% tissue sections had epithelial hyperplasia points with...
Abstract Cyclin D1, with a common G/A polymorphism in rs9344, is an essential regulator of the G1 phase cell cycles and plays important role several tumor types, homology cyclin D1 human papillomavirus (HPV)‐16 E7 brought our attention to CCND1 gene cervical cancer. A total 738 native Chinese subjects consist 327 cases 411 controls were enrolled this study. genotyping was analyzed by polymerase chain reaction‐restriction fragment length (PCR‐RFLP) partially verified sequencing genomic DNA...
This study was to assess whether human papillomavirus (HPV) resulting in genetic instability is one reason for the high incidence and mortality of cervical cancer Longnan.Between 2012 2016, a total 346 samples from Longnan were collected divided into four groups: cervicitis group (n=57), intraepithelial neoplasia I (CIN I, n=63), CIN II/III (n=79) invasive squamous cell carcinoma (SCC, n=147). HPV E6/E7 mRNA detected by Quantivirus® RNA 3.0 assay (bDNA). The markers DNA damage response (DDR)...
The present study was planned to investigate the characteristics of nosocomial infection and its effects on survival in advanced non-small cell lung cancer (NSCLC) patients. Retrospective analysis performed for 169 chemotherapy patients with NSCLC during hospitalization Binzhou City Central Hospital from March, 2013 January, 2015. In addition, 170 without were also involved as a control group. distribution major drug resistance Gram-negative (G-) Gram-positive (G+) analyzed. conditions...
Objective: This study aimed to identify reliable risk factors for residual/recurrent cervical intraepithelial lesions in patients with negative margins after cold-knife conization. Methods: A total of 2352 women HSILs (high-grade squamous lesions) who underwent conization between January 2014 and December 2020 were included; total, 1411 assigned the development cohort, 941 validation cohort. Multivariate logistic regression was used build four predictive models based on different...
Introduction Siraitia grosvenorii (Swingle) C. Jeffrey, is an edible and traditional medicine widely used in China. Mogroside V (MGV) mogrol (MG) are its main active ingredients, which have been found to be effective the treatment of neurodegenerative diseases recently. However, whether they can effectively treat Parkinson’s disease (PD) their underlying mechanisms not sufficiently explored. In this study, we investigated neuroprotective metabolic regulatory effects MGV MG on PD. Materials...
Objective To investigate the diagnostic accuracy and influencing factors of intraoperative frozen section pathological examination in endometrial carcinoma(EC). Methods From January 2006 to December 2014, 170 patients with EC who were hospitalized department Gynecology Obstetrics, Military General Hospital Beijing, chosen as study objects. The gold standard was postoperative paraffin embedded biopsy results. sensitivity specificity differences diagnosis tumor cell level, histological...
Objective To study the characteristics of craniocerebral injury caused by handgun bullet impacting on bulletproof helmet.Methods Fourteen healthy landrace pigs were involved and randomly divided into group(n =9)and control =5).The group shot vertically head under protection helmet plate with 9 mm at velocity 360 m/s.While dealt same process as except for use unarmed ammunition dose.The changes vital sign in early period retina two hours after observed.Porcine cerebrospinal fluid (CSF)at...
Objective To observe the infection status and distribution of gene subtypes human papillomavirus (HPV) in Huzhou. Methods Cervical exfoliated cells were collected from women who attended physical examination cervical HPV June 2017 to December Huzhou Maternal Child Health-Care hospital. A total 2 830 tested for 21 genotypes (including HPV-16, 18, 31, 59, 66, 53, 33, 58, 45, 56, 52, 35, 68, 51, 39, 82, 26, 73, 6, 11, 81), using real-time polymerase chain reaction (RT-PCR), investigated...
Abstract Background: Perivascular epithelioid cell tumor (PEComa) is an uncommon of mesenchymal origin which can arise at a variety visceral and soft tissue sites. It most often occurs in the uterus, but develops liver very infrequently, only 8% PEComa cases.Here, we present two pathologically proven cases liver, retrospectively discuss clinical, imaging histological features. Case presentation: Case1:A 54-year-old female patient with intermittent epigastric discomfort for 2 years aggravated...