A5037199747- Hepatitis B Virus Studies
- Potato Plant Research
- Cervical Cancer and HPV Research
- Nutritional Studies and Diet
- Carcinogens and Genotoxicity Assessment
- Diet and metabolism studies
- Bacterial Infections and Vaccines
- Genital Health and Disease
- Nutrition and Health in Aging
- Plant Pathogenic Bacteria Studies
- Pneumonia and Respiratory Infections
- Immunotherapy and Immune Responses
- Plant Pathogens and Resistance
- Hepatitis C virus research
- Plant-Microbe Interactions and Immunity
- Alcohol Consumption and Health Effects
- Advanced Sensor and Control Systems
- Adipokines, Inflammation, and Metabolic Diseases
- Herpesvirus Infections and Treatments
- Obesity, Physical Activity, Diet
- Sesame and Sesamin Research
- Eosinophilic Esophagitis
- Bacteriophages and microbial interactions
- Bacillus and Francisella bacterial research
- Connexins and lens biology
Anhui Agricultural University
2022-2024
Zhejiang University
2020-2024
The University of Sydney
2024
First Affiliated Hospital Zhejiang University
2024
Ministry of Agriculture and Rural Affairs
2021
Jiangsu Provincial Center for Disease Control and Prevention
2011-2019
General Hospital of Guangzhou Military Command
2014
Nanjing University of Aeronautics and Astronautics
2013
Xian Center for Disease Control and Prevention
2012
Abstract Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the air, oils, water, and food products we encounter every day. Among these exposures, consumption is a major route of PAH exposure for nonsmokers. The dietary levels vary among different countries; however, many studies have shown to be highly concerning human health. contamination mainly influenced by processing procedures cooking methods, they could attenuated modifying adding antioxidant‐rich marinades. Several PAHs...
Background Whether consumption of egg and cholesterol is detrimental to cardiovascular health longevity highly debated. Data from large-scale cohort studies are scarce. This study aimed examine the associations intakes with mortality all causes, disease (CVD), other causes in a US population. Methods findings Overall, 521,120 participants (aged 50–71 years, mean age = 62.2 41.2% women, 91.8% non-Hispanic white) were recruited 6 states 2 additional cities between 1995 1996 prospectively...
Abstract Background Increasing evidence highlights healthy dietary patterns and links daily cooking oil intake with chronic diseases including cardiovascular disease (CVD) diabetes. However, food-based supporting the consumption of oils in relation to total cardiometabolic mortality remains largely absent. We aim prospectively evaluate relations death from (CVD diabetes) other causes. Methods identified followed 521,120 participants aged 50–71 years National Institutes Health-American...
Background Hand, foot, and mouth disease (HFMD) has been emerging as an important public problem over the past few decades, especially in Asian Pacific regions. A national program on EV71 vaccine development against HFMD was initiated China, 2008, which called for a need seroepidemiological study target population. Methodology/Principal Findings This retrospective conducted Jiangsu Province, October, 2010. We measured neutralizing antibodies CoxA16 cohort of infants aged 2, 7, 12, 27–38...
This phase II/III, double-blind, randomized trial assessed the efficacy, immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in young Chinese women (ClinicalTrials.gov registration NCT00779766). Women aged 18-25 years from Jiangsu province were (1:1) to receive HPV (n = 3,026) or Al(OH)3 control 3,025) at months 0, 1 6. The primary objective was efficacy (VE) against HPV-16/18 associated 6-month persistent infection (PI) and/or cervical intraepithelial...
Abstract Background Cervical cancer is a major public health concern in China. We report the end‐of‐study results of phase II/III trial to assess efficacy, immunogenicity, and safety AS04‐human papillomavirus (HPV)‐16/18 vaccine Chinese women aged 18‐25 years followed for up 72 months after first vaccination. Results approximately 57 following vaccination have been previously reported. Methods Healthy 18‐25‐year‐old (N = 6051) were randomized (1:1) receive three doses AS04‐HPV‐16/18 or...
Abstract We previously reported the results of a phase II/III, double‐blind, randomized controlled study in Chinese women (NCT00779766) showing 94.2% (95% confidence interval: 62.7–99.9) HPV‐16/18 AS04‐adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6‐month (M) persistent infection (PI) with mean follow‐up <2 years, and immunogenicity until 7 months post‐dose 1. Here, we report safety from an event‐triggered analysis ~3 years...
Baseline human papillomavirus (HPV) prevalence and type distribution were evaluated in young Chinese women enrolled a clinical trial of an HPV vaccine (ClinicalTrials.gov registration NCT00779766). Cervical specimens blood samples collected at baseline from aged 18-25 years (n = 6,051) four sites across Jiangsu province. tested for DNA by SPF10 PCR-DEIA-LiPA25 version 1, HPV-16/18 type-specific polymerase chain reaction. Anti-HPV-16 anti-HPV-18 antibody titres quantified enzyme-linked...
Bacillus pumilus plays an important role in industrial application and biocontrol activities, as well causing humans plants disease, leading to economic losses biosafety concerns. However, until now, the pathogenesis underlying mechanisms of B. strains remain unclear. In our previous study, one representative isolate named HM-7 has been recovered proved be causal agent fruit rot on muskmelon (Cucumis melo). Herein, we present a complete annotated genome sequence that contains 4,111 coding...
Abstract The extracytoplasmic function (ECF) sigma factor AlgU is involved in the regulation of various virulence-related pathways Pseudomonas syringae , especially alginate biosynthesis and motility, role differs among P. pathovars. However, to date, mechanism its virulence pv. actinidiae ( Psa ) still unclear. ECF factors are a class alternative that typically with anti-sigma as part cell-surface signaling systems. Under non-inducing conditions, remains inhibited by such MucA MucB. To...
Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models insulin resistance reveal consistent decrease in level processing peptidase miPEP. To determine role miPEP resistance. experimentally test this observation, generated adipocyte-specific knockout mice to interrogate its aetiology We observed strong phenotype characterised...
Background: Hypertensive patients are sensitive to the amount of dietary cholesterol intake, especially from whole eggs. Whether egg and consumption suitable for hypertensive is still controversial. Aim: The objective study was examine associations intake eggs as well with total mortality in a Chinese nationwide cohort. Methods: We utilized data China Health Nutrition Survey (CHNS) year 1991 2015. Cumulative averages were calculated represent long-term diet participants each available round...
AbstractPertussis continues to circulate in Chinese communities and older children, adolescents adults are sources of infection for unprotected infants. Two studies conducted Jiangsu Province the People’s Republic China assessed immunogenicity, reactogenicity safety Boostrix™, a combined reduced antigen content diphtheria-tetanus-acellular pertussis vaccine (dTpa) when administered as booster dose children 6−8 years age. Immunogenicity was before one month after vaccination subset....
The current study developed an ultrahigh-performance liquid chromatography tandem mass spectrometry method to simultaneously analyze cascade metabolites of acrylamide in urine rats and humans, including acrylamide, glycidamide, N-acetyl-S-(2-carbamoylethyl)-l-cysteine (AAMA), N-acetyl-S-(2-carbamoylethyl)-l-cysteine-sulfoxide, N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-l-cysteine, N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-l-cysteine. A solid-phase extraction procedure was novelly used purify all...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Abstract Background Pseudomonas syringae pv. actinidiae (Psa) is an important bacterial plant pathogen that causes severe damage to the kiwifruit industry worldwide. Three Psa strains were recently obtained from different orchards in Anhui Province, China. The present study mainly focused on variations virulence and genome characteristics of these based pathogenicity assays comparative genomic analyses. Results identified as biovar 3 (Psa3), along with strain QSY6 showing higher than JZY2...
Acrylamide is classified as a Class 2A carcinogen and mainly metabolized to produce hepatotoxicity. Phosphatidylcholine thought protect the liver from damage, but protective role of phosphatidylcholine on acrylamide-exposed metabolic disorders remains unclear. We investigated effect hepatic metabolism in rats exposed acrylamide using metabolomics molecular biology approaches. Overall, 32 endogenous biomarkers 4 exposure were identified differential signature metabolites responsible for...