A5048372642- Cancer, Hypoxia, and Metabolism
- Urban Transport and Accessibility
- Ferroptosis and cancer prognosis
- Transportation Planning and Optimization
- Heat Transfer and Boiling Studies
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Environmental Sustainability in Business
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Corporate Finance and Governance
- Nuclear Engineering Thermal-Hydraulics
- Human Mobility and Location-Based Analysis
- RNA modifications and cancer
- Transportation and Mobility Innovations
- Energy, Environment, Economic Growth
- Gut microbiota and health
- Polyamine Metabolism and Applications
- Statistical Methods in Clinical Trials
- Helicobacter pylori-related gastroenterology studies
- Pain Management and Treatment
- Private Equity and Venture Capital
Hangzhou Hospital of Traditional Chinese Medicine
2025
Yale University
2021-2024
Renmin University of China
2021-2024
Zhejiang University
2012-2024
Wenzhou Medical University
2023-2024
Xi'an Physical Education University
2023-2024
Affiliated Eye Hospital of Wenzhou Medical College
2023-2024
Affiliated Hospital of Qingdao University
2024
Jiangsu University
2021-2024
Harbin Engineering University
2024
Aberrant tumor metabolism is a hallmark of cancer in which metabolic rewiring can support growth under nutrient deficient conditions. KRAS mutations occur 35-45% all colorectal (CRC) cases and are difficult to treat. The relationship between mutant aberrant CRCs has not been fully explored could be target for intervention. We previously acquired non-targeted metabolomics data from 161 tissues 39 normal colon stage I-III chemotherapy naïve CRC patients. In this study, we revealed that only...
Dopamine transmission from midbrain ventral tegmental area (VTA) neurons underlies behavioral processes related to motivation and drug addiction. The pedunculopontine nucleus (PPTg) is a brainstem containing glutamate-, acetylcholine-, GABA-releasing with connections basal ganglia limbic brain regions. Here we investigated the role of PPTg glutamate in reinforcement, an emphasis on their projections VTA dopamine neurons. We used cell-type-specific anterograde tracing optogenetic methods...
The limitations surrounding the education and teaching of green building courses in higher institutions are becoming increasingly evident. roles instructors, learning environments building-related courses, impact student engagement these attracting significant academic interest. This study delves into cross-level mediating climate helping behaviors, exploring link between instructors’ sense responsibility engagement. It employs a multi-layer structural equation model for statistical...
The emergence of targeted therapies for MET exon 14 (METex14) skipping mutations has significantly changed the treatment landscape NSCLC and other solid tumors. METex14 results in activating MET-HGF pathway promoting tumor cell proliferation, migration, preventing apoptosis. Type Ib inhibitors, designed to selectively target "DFG-in" conformation MET, characteristically bind ATP-binding pocket a U-shaped conformation, extending into solvent-accessible region interact strongly with residue...
Abstract Background Bile acids are known to be genotoxic and contribute colorectal cancer (CRC). However, the link between CRC tumor bile location, patient sex, microbiome, immune-regulatory cells, prognosis is not clear. Methods We conducted acid analysis using targeted liquid chromatography–mass spectrometry (LC–MS) on tissues from patients ( n = 228) with survival analysis. performed quantitative immunofluorescence (QIF) tumors examine immune cells. Results Twelve of were significantly...
Using the sample of A-share listed companies from 2011 to 2022, we show a robust negative relationship between customer concentration and stock price crash risk in China. This finding contrasts with previous research based on U.S. firms, which shows that is positively correlated risk. We believe Chinese imperfect capital market key factor contributing this divergence. reveal concentrated base can reduce by improving corporate governance supply chain transparency. Heterogeneity analysis...
This study aims to explore the application effect of Child Life intervention on pain, anxiety, fatigue, and sleep disturbance in children with acute leukemia.In a single-blinded, parallel-group randomized controlled trial, 96 leukemia were either group, which received twice week for 8 weeks, or control routine care. Outcomes evaluated at baseline day 3 postintervention.All participants completed study. Compared group showed significant reduction (P < 0.001). However, no differences...
Praziquantel (PZQ) is a broad-spectrum antiparasitic drug used in mammals and fish. In this study, we developed an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) for the detection of PZQ residues. The hapten PZQ-HS produced by introducing amino group at benzene ring synthesized immunogen coating antigen with carrier proteins. Highly sensitive monoclonal antibodies (mAbs) were prepared following mouse immunization cell fusion. Under optimum conditions, half maximal...
The interplay between the sex-specific differences in tumor metabolome and colorectal cancer (CRC) prognosis has never been studied represents an opportunity to improve patient outcomes. This study examines link by sex for CRC patients. Using untargeted metabolomics analysis, abundances of 91 metabolites were obtained from primary tissues 197 patients (N = 95 females, N 102 males) after surgical colectomy stage I-III CRC. Cox Proportional hazard (PH) regression models estimated associations...
A monoclonal antibody (mAb), 2C9, selective for four eugenol compounds, was developed based on the derivatives (Eug-1). The semi-inhibitory concentrations (IC50) of this against eugenol, isoeugenol, methyl and isoeugenol were 0.043, 0.302, 0.016, 0.082 μg/mL, respectively, detection limits (LOD) 0.012, 0.070, 0.004 0.024 μg/mL. With exception which had cross-reactivity less than 15%, other compounds good, ranging from 52.4% to 269%. In ic-ELISA recovery test, between 80% 94%, indicating that...