A5026860953- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- 3D Printing in Biomedical Research
- Urinary Bladder and Prostate Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Animal Vocal Communication and Behavior
- Diabetes Treatment and Management
- Cell Image Analysis Techniques
- Bone Tissue Engineering Materials
- Advanced Fluorescence Microscopy Techniques
- Receptor Mechanisms and Signaling
- Urological Disorders and Treatments
- Animal Behavior and Reproduction
- Pelvic floor disorders treatments
University of California, San Diego
2016-2021
Highlights•Early social deprivation (ESD) causes downregulation of Drd3 signaling in the LS•Blunted LS neuronal activity mediate ESD-induced dysfunctions•Drd3 has corresponding effects on LS•Activation normalize impairments ESD miceSummaryEarly life stress (ELS) form child abuse/neglect is associated with an increased risk developing dysfunction adulthood. Little known, however, about neural substrates or neuromodulatory that govern ELS-induced dysfunction. Here, we show dopamine receptor 3...
Drugs of abuse induce persistent remodeling reward circuit function, a process thought to underlie the emergence drug craving and relapse use. However, how circuit-specific, drug-induced molecular cellular plasticity can have distributed effects on mesolimbic dopamine system facilitate use is not fully elucidated. Here, we demonstrate that receptor D3 (DRD3)-dependent in ventral pallidum (VP) drives potentiation release nucleus accumbens during cocaine seeking after abstinence. We show two...
Dopamine transmission from midbrain ventral tegmental area (VTA) neurons underlies behavioral processes related to motivation and drug addiction. The pedunculopontine nucleus (PPTg) is a brainstem containing glutamate-, acetylcholine-, GABA-releasing with connections basal ganglia limbic brain regions. Here we investigated the role of PPTg glutamate in reinforcement, an emphasis on their projections VTA dopamine neurons. We used cell-type-specific anterograde tracing optogenetic methods...
Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) and grid are thought to support spatial navigation. To determine whether these computations dependent on local circuits, we record neuronal activity mEC layers II III optogenetically perturb locally projecting layer pyramidal cells. We find that sharply tuned HD only weakly responsive while speed, broadly show pronounced transient excitatory inhibitory responses. During brief period of feedback...
The classic basal ganglia circuit model asserts a complete segregation of the two striatal output pathways. Empirical data argue that, in addition to indirect-pathway projection neurons (iSPNs), direct-pathway (dSPNs) innervate external globus pallidus (GPe). However, functions latter were not known. In this study, we interrogated organization principles striatopallidal projections and their roles full-body movement mice (both males females). contrast canonical motor-promoting response dSPNs...
The basal ganglia are a group of subcortical nuclei that regulates motor and cognitive functions 1,2 . Recent identification neuronal heterogeneity in the suggests functionally distinct neural circuits defined by their efferent projections exist even within same 3-5 This distinction may account for multitude symptoms associated with disorders such as Parkinson’s disease (PD) 6,7 However, our incomplete understanding functional organization has hindered further investigation individual...
Glucagon Like Peptide 1 (GLP-1) positive neurons in the hindbrain Nucleus Tractus Solitarius (NTS) send robust projections to paraventricular nucleus of hypothalamus (PVN), which is involved regulation food intake. However, it unclear whether this pathway sufficient and necessary control feeding behavior, or how GLP-1 affect synaptic function modulate Here, we found that specific stimulation afferent fibers within PVN suppress intake independent glutamate release. receptor (GLP-1R)...
Dopamine transmission from midbrain ventral tegmental area (VTA) neurons underlies behavioral processes related to motivation and drug addiction. The pedunculopontine nucleus (PPTg) is a brainstem containing glutamate-, acetylcholine-, GABA-releasing with connections basal ganglia limbic brain regions. Here we investigated the role of PPTg glutamate in reinforcement, an emphasis on their projections VTA dopamine neurons. We used cell-type-specific anterograde tracing optogenetic methods...
Abstract The classic basal ganglia circuit model asserts a complete segregation of the two striatal output pathways. Empirical data argue that, in addition to indirect-pathway projection neurons (iSPNs), direct-pathway (dSPNs) innervate external globus pallidus (GPe). However, functions latter were not known. In this study, we interrogated organization principles striatopallidal projections and their roles full-body movement mice (both males females). contrast canonical motor-promoting...
Urination may occur either reflexively in response to a full bladder or deliberately irrespective of immediate need. Voluntary control is desired because it ensures that waste expelled when consciously and socially appropriate 1,2 . Urine release requires two primary components: pressure urethral relaxation 1–3 Although the contracts during urination, its slow smooth muscle not under direct voluntary contraction alone sufficient for voiding. The decisive action urination at sphincter, where...