A5000114345- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Eating Disorders and Behaviors
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Obesity, Physical Activity, Diet
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
- Pain Mechanisms and Treatments
- Food Security and Health in Diverse Populations
- Transcranial Magnetic Stimulation Studies
- Distributed and Parallel Computing Systems
- Particle physics theoretical and experimental studies
- Advanced Fluorescence Microscopy Techniques
- Neurobiology and Insect Physiology Research
- Biomedical and Engineering Education
- Treatment of Major Depression
- Child Nutrition and Feeding Issues
University of California, Berkeley
2016-2025
Stanford University
2011-2015
Energy Sciences Network
2010
Goethe University Frankfurt
2008
Philipps University of Marburg
2008
Dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in Parkinson's disease. Their selective loss causes major motor symptoms of disease, but for high vulnerability SN DA neurons, compared neighbouring, more resistant ventral tegmental area dopamine still unclear. Consequently, there is no cure available Current therapies compensate progressive by administering its precursor l-DOPA and/or D2-receptor agonists. D2-autoreceptors and Cav1.3-containing...
Abstract The sucrose preference test (SPT) measures the relative of over water to assess hedonic behaviors in rodents. Yet, it remains uncertain what extent SPT reflects other behavioral components, such as learning, memory, motivation, and choice. Here, we conducted an experimental computational decomposition mouse behavior discovered previously unrecognized subcomponents associated with changes preference. We show that acute chronic stress have sex-dependent effects on preference, but...
Abstract Calorie-rich foods, particularly those that are high in fat and sugar, evoke pleasure both humans animals 1 . However, prolonged consumption of such foods may reduce their hedonic value, potentially contributing to obesity 2–4 Here we investigated this phenomenon mice on a chronic high-fat diet (HFD). Although these preferred food over regular chow home cages, they showed reduced interest calorie-rich no-effort setting. This paradoxical decrease feeding has been reported previously...
The dorsal raphe (DR) is a heterogeneous nucleus containing dopamine (DA), serotonin (5HT), γ-aminobutyric acid (GABA) and glutamate neurons. Consequently, investigations of DR circuitry require Cre-driver lines that restrict transgene expression to precisely defined cell populations. Here, we present systematic evaluation mouse targeting neuromodulatory cells in the DR. We find substantial differences specificity between DA neurons, penetrance 5HT Using these tools map circuits, show...
A major challenge for neuroscience, public health, and evolutionary biology is to understand the effects of scarcity uncertainty on developing brain. Currently, a significant fraction children adolescents worldwide experience insecure access food. The goal our work was test in mice whether transient versus secure food during juvenile-adolescent period produced lasting differences learning, decision-making, dopamine system adulthood. We manipulated feeding schedules from postnatal day (P)21...
Abstract Dopamine controls diverse behaviors and their dysregulation contributes to many disorders. Our ability understand manipulate the function of dopamine is limited by heterogenous nature dopaminergic projections, diversity neurons that are regulated dopamine, varying distribution five receptors (DARs), complex dynamics release. In order improve our specifically modulate distinct DARs, here we develop a photo-pharmacological strategy using Membrane anchored Photoswitchable orthogonal...