A5065763749- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Plant Virus Research Studies
- Hydrocarbon exploration and reservoir analysis
- High Altitude and Hypoxia
- Digestive system and related health
- Infant Nutrition and Health
- Ruminant Nutrition and Digestive Physiology
- Rangeland Management and Livestock Ecology
- Soil Carbon and Nitrogen Dynamics
- Soil Mechanics and Vehicle Dynamics
- Hepatitis B Virus Studies
- Soil and Water Nutrient Dynamics
- Neurogenesis and neuroplasticity mechanisms
- Geological and Geophysical Studies
- Cervical Cancer and HPV Research
- Mitochondrial Function and Pathology
- Gout, Hyperuricemia, Uric Acid
- Geological Studies and Exploration
Tibet Academy of Agricultural and Animal Husbandry Sciences
2013-2024
Guizhou Academy of Sciences
2022-2024
Animal Science Research Institute
2021-2024
Zhejiang University
2020-2024
Hangzhou Normal University
2020-2024
Affiliated Hospital of Hangzhou Normal University
2024
Second Xiangya Hospital of Central South University
2023-2024
Central South University
2023-2024
Xi'an University of Science and Technology
2024
Sinopec (China)
2013-2023
Yak (Bos grunniens) is an unique ruminant species in the Qinghai-Tibetan Plateau (QTP). The gastrointestinal tract (GIT) microbiota not only associated with nutrients metabolism, but also contributes to host's local adaptation. Examining between cattle and yak different geography could improve our understanding about role of metabolism To this end, we compared rumen, reticulum, omasum abomasum dairy cattle, yellow three herds (WQ yak, SZ ZB yak) lived altitude, based on sequencing bacterial...
Abstract Background The Intramuscular fat (IMF) content in meat products, which is positively correlated with quality, an important trait considered by consumers. regulation of IMF deposition species specific. However, the IMF-deposition-related mRNA and non-coding RNA their regulatory network yak ( Bos grunniens ) remain unknown. High-throughput sequencing technology provides a powerful approach for analyzing association between transcriptome-related differences specific traits animals....
This phase II/III, double-blind, randomized trial assessed the efficacy, immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in young Chinese women (ClinicalTrials.gov registration NCT00779766). Women aged 18-25 years from Jiangsu province were (1:1) to receive HPV (n = 3,026) or Al(OH)3 control 3,025) at months 0, 1 6. The primary objective was efficacy (VE) against HPV-16/18 associated 6-month persistent infection (PI) and/or cervical intraepithelial...
Genomic structural variation represents a source for genetic and phenotypic variation, which may be subject to selection during the environmental adaptation population differentiation. Here, we described genome-wide analysis of copy number variations (CNVs) in 16 populations yak based on genome resequencing data CNV-based cluster analyses these populations. In total, identified 51,461 CNV events defined 3174 regions (CNVRs) that covered 163.8 Mb (6.2%) with more "loss" than both "gain"...
Abstract Background Cervical cancer is a major public health concern in China. We report the end‐of‐study results of phase II/III trial to assess efficacy, immunogenicity, and safety AS04‐human papillomavirus (HPV)‐16/18 vaccine Chinese women aged 18‐25 years followed for up 72 months after first vaccination. Results approximately 57 following vaccination have been previously reported. Methods Healthy 18‐25‐year‐old (N = 6051) were randomized (1:1) receive three doses AS04‐HPV‐16/18 or...
Abstract Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines involved nearly every aspect of cellular functions such as migration, survival, proliferation, differentiation. Oligodendrocytes the myelin-forming cells central nervous system play critical roles conduction action potentials, supply metabolic components for axons, other functions. Emerging evidence suggests that both...
Abstract Oligodendrocyte differentiation and myelination in the central nervous system are controlled coordinated by a complex gene regulatory network that contains several transcription factors, including Zfp488 Nkx2.2. Despite proven role oligodendrocyte little is known about exact mode of Nkx2.2 action, their target genes. Here, we used overexpression differentiating CG4 cells to identify aspects oligodendroglial expression profile depend on these factors. Although both factors primarily...
The yak is a valuable species in the Qinghai-Tibet Plateau of China. Nevertheless, molecular mechanisms underlying its adaptation to high-altitude environments remain largely unknown. In present study, comparative transcriptome sequencing was performed for lung and gluteus tissues from two low-altitude cattle (Sanjiang Holstein cattle), Tibetan (living at moderate altitude), high altitude) differentially expressed genes were validated using real-time quantitative PCR. results showed that...
Microbial infections due to bacteria, viruses, and molds are a serious threat both human life the health of other organisms. To develop inexpensive, easy-to-prepare, efficient, portable nano-antibacterial materials, as well explore antibacterial prospects cationic agents, in this work, six different membrane materials were prepared by electrostatic spinning method characterized scanning electron microscopy (SEM), transmission (TEM), X-ray diffraction (XRD), Fourier transform infrared...
Abstract We previously reported the results of a phase II/III, double‐blind, randomized controlled study in Chinese women (NCT00779766) showing 94.2% (95% confidence interval: 62.7–99.9) HPV‐16/18 AS04‐adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6‐month (M) persistent infection (PI) with mean follow‐up <2 years, and immunogenicity until 7 months post‐dose 1. Here, we report safety from an event‐triggered analysis ~3 years...
Rumen microbiota are closely linked to feed utilization and environmental adaptability of ruminants. At present, little is known about the influence different extreme environments on rumen yaks. In this study, 30 ruminal fluid samples from healthy female yaks (average 280 kg BW) in 5-8 years life were collected three regions Tibet, China, compared by gas chromatography high-throughput sequencing. Results showed that propionic acid, butyric total volatile fatty acids significantly (
Abstract Background The yak ( Bos grunniens ) is a large ruminant species that lives in high-altitude regions and exhibits excellent adaptation to the plateau environments. To further understand genetic characteristics adaptive mechanisms of yak, we have developed multi-omics database including genome, transcriptome, proteome, DNA methylation data. Description Yak Genome Database http://yakgenomics.com/ integrates research results methylation, provides an integrated platform for researchers...
This paper proposes a flow-path network (FPN) model to simulate complex surface flow based on drainage-constrained triangulated irregular (TIN). The TIN was constructed using critical points and drainage lines extracted from digital terrain surface. Runoff generated the simplified as 'water volumes' at constrained random that were then used starting of paths (i.e. source points). for each volume' by tracing direction point over stream system outlet watershed. FPN represented set...
Abstract Background On the Qinghai–Tibet Plateau, known as roof ridge of world, yak is a precious cattle species that has been indispensable to human beings living in this high-altitude area. However, origin domestication, dispersal route, and divergence domestic yaks from different areas are poorly understood. Results Here, we resequenced genome 91 individuals 31 populations 1 wild throughout China. Using population genomics approach, observed considerable genetic variation. Phylogenetic...
Abstract Yak is an important livestock animal for the people indigenous to harsh, oxygen‐limited Qinghai‐Tibetan Plateau and Hindu Kush ranges of Himalayas. The yak genome was sequenced in 2012, but its assembly fragmented because inherent limitations Illumina sequencing technology used analyse it. An accurate complete reference essential study genetic variations this species. Long‐read sequences are more than their short‐read counterparts have been successfully applied towards high‐quality...
The yak (Bos grunniens), an indigenous bovine on the Qinghai-Tibetan plateau (QTP), is reported to digest low quality forage a greater extent and require less protein energy for maintenance than introduced Qaidam cattle taurus). Ruminal bacteria play major role in feed degradation, therefore, we hypothesized that ruminal composition would differ between yaks cattle, confer advantage poor diets. To test our hypothesis, determined profiles, rumen fermentation parameters, enzyme activities...
Traditionally, yaks graze only natural pasture all year round without supplements. Forage intake of lactating is below energy and protein requirements, even in the summer, suckling lose a substantial amount significant body weight. Today, to mitigate loss weight, supplementary feed being offered yaks. However, effects on ruminal bacterial communities unknown. In current study, we examined effect microbiota, using 16S rRNA sequencing, volatile fatty acids (VFAs). Twenty-four similar weight...
Yak is the unique Bovidae species in Qinghai-Tibetan Plateau. A previous proteomic study has compared yak muscle tissue to one cattle strain using isobaric tags for relative and absolute quantification approach. In this study, further investigate molecular mechanisms underlying adaptation, profiles of gluteus were between moderate-altitude (Tibetan cattle) two low-altitude strains (Holstein Sanjiang a label-free quantitative method. The comparisons identified 20, 364, 143 upregulated...
Yaks display unique properties of the lung and heart, enabling their adaptation to high-altitude environments, but underlying molecular mechanisms are still largely unknown. In present study, proteome differences in heart tissues were compared between yak (Bos grunniens) three cattle strains taurus, Holstein, Sanjiang Tibetan cattle) using sequential window acquisition all theoretical mass spectra/data-independent (SWATH/DIA) proteomic method. total, 51,755 peptides 7215 proteins identified....
Background The yak ( Bos grunniens ) is an important livestock species that can survive the extremely cold, harsh, and oxygen-poor conditions of Qinghai-Tibetan Plateau provide meat, milk, transportation for Tibetans living there. However, regulatory network drive this hypoxic adaptation remain elusive. Results heart tissues from LeiRoqi (LWQY) their related cattle Taurus breeds, which are two native breeds located in high altitude (HAC) low (LAC) regions, respectively, were collected RNA...