A5060134247- Urinary Bladder and Prostate Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Sulfur Compounds in Biology
- Trace Elements in Health
- Alzheimer's disease research and treatments
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Hormonal and reproductive studies
- Urticaria and Related Conditions
- Chemical and Physical Studies
- Sexual function and dysfunction studies
- Obstructive Sleep Apnea Research
- Tryptophan and brain disorders
- Pregnancy and Medication Impact
- Neurological Complications and Syndromes
- Neuroscience and Neuropharmacology Research
- Anodic Oxide Films and Nanostructures
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024
Japan Society for the Promotion of Science
2020-2022
Kōchi University
2017-2022
Japan Society for the Promotion of Science London
2020-2022
Kochi Medical School Hospital
2018-2022
Honda (Japan)
2018
Narishige (Japan)
2018
Smoking Research Foundation
2018
Shimizu (Japan)
2018
Daegu University
2018
Extracellular zinc, which is released from hippocampal neurons in response to brain ischaemia, triggers morphological changes microglia. Under ischaemic conditions, microglia exhibit two opposite activation states (M1 and M2 activation), may be further regulated by the microenvironment. We examined role of extracellular zinc on M1 Pre-treatment with 30-60 μM ZnCl2 resulted dose-dependent increases interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNFα) secretion...
Abstract Oligodendrocyte differentiation and myelination in the central nervous system are controlled coordinated by a complex gene regulatory network that contains several transcription factors, including Zfp488 Nkx2.2. Despite proven role oligodendrocyte little is known about exact mode of Nkx2.2 action, their target genes. Here, we used overexpression differentiating CG4 cells to identify aspects oligodendroglial expression profile depend on these factors. Although both factors primarily...
To clarify the roles of hydrogen sulfide (H2 S), an endogenous gasotransmitter, in rat bladder and prostate, we investigated distribution enzymes related to H2 S biosynthesis (cystathionine β-synthase [CBS], cystathionine γ-lyase [CSE], 3-mercaptopyruvate sulfurtransferase [MPST], cysteine aminotransferase [CAT], D-amino acid oxidase [DAO]) content S. We also effects donors (NaHS GYY4137) on contractility both tissues micturition.The these was by real-time PCR, Western blot,...
Abstract Microglia, the resident immune cells of central nervous system, can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to attenuation brain inflammation. Although previous studies have indicated that zinc promotes activation, effect on microglial activation remains be determined....
OBJECTIVE Glioma stem cells (GSCs) are responsible for tumor initiation, therapeutic resistance, and recurrence. CD146 is mainly expressed in dividing GSCs regulates cell cycle progression. However, the evaluation of efficacy targeted therapy against vivo remains to be investigated. In this study, authors aimed develop gene targeting using chitosan oligosaccharide lactate (COL) nanoparticles (NPs) conjugated with folic acid–polyethylene glycol (FA-PEG-COL NPs) vitro delivery...
Abstract Aim Brain nitric oxide (NO) have been reported in regulation of the sympatho‐adrenomedullary system, which can affect voiding and storage functions. Therefore, we investigated effects intracerebroventricularly (icv) administered 3‐(4‐morpholinyl)sydnonimine, hydrochloride (SIN‐1) (NO donor) on micturition reflex, focusing their dependence system brain N ‐methyl‐D‐aspartate (NMDA) α ‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionate (AMPA) receptors urethane‐anesthetized (0.8 g/kg, ip)...
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology I1 Apr 2018MP09-03 HYDROGEN SULFIDE CAN FUNCTION AS AN ENDOGENOUS RELAXATION FACTOR IN THE RAT BLADDER AND PROSTATE Takahiro Shimizu, Suo Zou, Shogo Youichirou Higashi, Hideaki Ono, Kumiko Nakamura, Takaaki Aratake, Masaki Yamamoto, Tomoya Hamada, Yoshiki Nagao, Masashi Honda, and Motoaki Saito ShimizuTakahiro Shimizu More articles by this author , ZouSuo Zou ShimizuShogo HigashiYouichirou Higashi OnoHideaki...
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology I1 Apr 2018MP09-09 BRAIN NITRIC OXIDE CAN INDUCE FREQUENT URINATION IN RATS Takahiro Shimizu, Hideaki Ono, Shogo Youichirou Higashi, Suo Zou, Masaki Yamamoto, Takaaki Aratake, Tomoya Hamada, Yoshiki Nagao, Yusuke Ueba, Masashi Honda, and Motoaki Saito ShimizuTakahiro Shimizu More articles by this author , OnoHideaki Ono ShimizuShogo HigashiYouichirou Higashi ZouSuo Zou YamamotoMasaki Yamamoto AratakeTakaaki...
[BACKGROUND] Under ischemic conditions, microglia exhibit two opposite activation states (inflammatory M1 and anti-inflammatory M2 activation). Recent studies have indicated that increase in the exacerbates post-ischemic brain damage. We previously demonstrated ischemia-induced extracellular zinc release from neurons primes to enhance production of pro-inflammatory cytokines via reactive oxygen species (ROS) generation response stimuli. Here, we evaluate effect marine-derived compound-A...
Background: Hydrogen sulfide (H2S), an endogenous gasotransmitter, has a wide range of biological functions including neuromodulation, vasorelaxation and cytoprotection. In the lower urinary tract, however, physiological roles H2S have not been clarified in detail yet. this study, we investigated (1) tissue distributions enzymes related to biosynthesis [cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MPST), cysteine aminotransferase (CAT)...
Background: Peripheral nitric oxide (NO) has a local inhibitory effect on urination, while, in the central nervous system, NO seems to have both and facilitatory effects. We previously reported that SIN-1 (NO donor) centrally activated sympatho-adrenomedullary (SA) system rats. In this study, we investigated effects of administered micturition their dependence SA
Introduction: Psychological stress is involved in the development of lower urinary tract symptoms. We investigated effects centrally administered angiotensin II (Ang II), a stress-related neuropeptide on micturition reflex, and downstream signaling mechanisms.
[Background] Microglia are the resident immune cells of central nervous system. They polarized into two opposite activation states known as neurodegenerative M1 and neuroprotective M2. Arginase (Arg)-1 expressed in M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for L-arginine (L-Arg), which contributes to attenuation brain inflammation. On other hand, recent researches demonstrated that excessive Arg-1 depletion L-Arg observed Alzheimer's disease...