A5100681912- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Cancer-related molecular mechanisms research
- Pickering emulsions and particle stabilization
- Photonic Crystals and Applications
- Bacterial Infections and Vaccines
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Folklore, Mythology, and Literature Studies
- Urban Transport and Accessibility
- Maternal and fetal healthcare
- Renal cell carcinoma treatment
- Peroxisome Proliferator-Activated Receptors
- Urinary and Genital Oncology Studies
- Systemic Lupus Erythematosus Research
- Selenium in Biological Systems
- Surgical site infection prevention
- Sperm and Testicular Function
- Chinese history and philosophy
- Maternal and Perinatal Health Interventions
- Chemical synthesis and alkaloids
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Pharmaceutical studies and practices
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
North China University of Science and Technology
2023-2024
Western University
2024
Binzhou University
2014-2023
Binzhou Medical University
2014-2023
Johnson & Johnson (United States)
2021-2023
Shandong University of Finance and Economics
2022-2023
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
Wuhan Institute of Virology
2020-2022
Abstract Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology not been explored. Here we demonstrate a critical for IRF9 mediating neointima formation following injury. Notably, mice, ablation inhibits the proliferation migration of smooth muscle cells (VSMCs) attenuates intimal thickening response to injury, whereas gain-of-function promotes VSMC migration, which aggravates arterial narrowing....
Mindin/spondin 2, an extracellular matrix (ECM) component that belongs to the thrombospondin type 1 (TSR) class of molecules, plays prominent roles in regulation inflammatory responses, angiogenesis and metabolic disorders. Our most recent studies indicated mindin is largely involved initiation development cardiac cerebrovascular diseases [Zhu et al. (2014) J. Hepatol. 60, 1046–1054; Bian (2012) Mol. Med. 90, 895–910; Wang (2013) Exp. Neurol. 247, 506–516; Yan (2011) Cardiovasc. Res. 92,...
The COVID-19 outbreak is becoming a public health emergency. Data are limited on the clinical characteristics and causes of death. A retrospective analysis deaths were performed for patients' characteristics, laboratory results, In total, 56 patients (72.7%) decedents (male–female ratio 51:26, mean age 71 ± 13, survival time 17.4 8.4 days) had comorbidities. Acute respiratory failure (ARF) sepsis main Increases in C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer lactic acid...
Incorporating phosphorus (P) into the active metals of a catalyst is an effective strategy to enhance catalytic performance. However, mechanisms underlying influence introduced species on performance remain largely unknown. Herein, we observe pronounced shift in product selectivity CO2 hydrogenation from CH4 CO upon introducing P Ru/SiO2 catalysts. This alteration attributed role as "fence" hindering migration H species. The adsorbed CO, key intermediate for methanation, preferentially...
Grisemycin (1), the first sulfur angucyclinone with an unusual ether-bridged system, was isolated from a marine-derived Streptomyces griseus strain M268. Its novel, here cage-like, structure determined by spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited modestly selective activity against HL-60 cell line IC50 value of 31.54 μM. Futhermore, absolute stereochemistry kiamycin (2), 1,12-epoxybenz[a]anthracene, previously obtained same strain, established...
We develop a salt-templated route to monodisperse hollow nanostructures in green, robust, efficient, cost-effective and scalable manner.
Interferon regulatory factor 8 (IRF8), a member of the IRF transcription family, was recently implicated in vascular diseases. In present study, using mouse left carotid artery wire injury model, we unexpectedly observed that expression IRF8 greatly enhanced smooth muscle cells (SMCs) by injury. Compared with wild-type controls, global knockout mice exhibited reduced neointimal lesions and maintained SMC marker gene expression. We further generated SMC-specific transgenic an SM22α-driven...
Background Interferon regulatory factor 7 ( IRF 7), a member of the interferon family, plays important roles in innate immunity and immune cell differentiation. However, role neointima formation is currently unknown. Methods Results Significant decreases expression were observed vascular smooth muscle cells VSMC s) following carotid artery injury vivo platelet‐derived growth factor‐ BB PDGF ‐ ) stimulation vitro. Compared with non‐transgenic NTG controls, SMC ‐specific transgenic 7‐ TG mice...
We report the gram-scale hydrothermal synthesis of superparamagnetic Fe3O4 CNCs with superior long-term charge stability, which are suitable building blocks for magnetically responsive photonic crystals (MRPCs) widely, rapidly and reversibly tunable diffractions across visible near IR range, as well stability performances. The scalable excellent colloidal will facilitate their wide application in photonics, biomedicine, catalysis other areas.
The spatial distribution and accessibility of urban public service facilities affect socioeconomic factors in the lives residents, especially housing prices. Given that most previous studies focus on a certain, single type facility its impact prices, this research uses improved two-step floating catchment area (2SFCA) methods by considering differences capacity different types real life to evaluate their residential communities Jinan city based 3117 covering 11 kinds facilitates. Then, we...
Vascular smooth muscle cell (VSMC) proliferation is central to the pathophysiology of neo-intima formation. Interferon regulatory factor 3 (IRF3) inhibits growth cancer cells and fibroblasts. However, role IRF3 in vascular formation unknown. We evaluated protective against mice underlying mechanisms.IRF3 expression was down-regulated VSMCs after carotid wire injury vivo, SMCs platelet-derived (PDGF)-BB challenge vitro. Global knockout (IRF3-KO) led accelerated VSMCs, whereas opposite seen...
RNA interference (RNAi) is an intrinsic antiviral immune mechanism conserved in diverse eukaryotic organisms. However, the by which RNAi mammals regulated poorly understood. In this study, we uncovered that E3 ubiquitin ligase STIP1 homology and U-box-containing protein 1 (STUB1) was a new regulator of machinery mammals. We found STUB1 interacted with ubiquitinated AGO2, targeted it for degradation chaperon-dependent manner. promoted formation Lys48 (K48)-linked polyubiquitin chains on...
The mechanism of silica etching by hot water is elucidated which allows the controlled synthesis mesoporous nanostructures.
Abstract Site‐selective growth on non‐spherical seeds provides an indispensable route to hierarchical complex nanostructures that are interesting for diverse applications. However, this has only been achieved through epitaxial growth, which is restricted crystalline materials with similar crystal structures and physicochemical properties. A non‐epitaxial strategy reported nanostructures, where site‐selective controlled by the curvature of seeds. This effective silica nanorods from different...
A unique ring C-expanded angucyclinone, oxemycin (1), and seven new ring-cleavage derivatives (2–5 9–11) were isolated from the marine actinomycete Streptomyces pratensis KCB-132, together with eight known analogues (6–8 12–16). Their structures elucidated by spectroscopic analyses, single-crystal X-ray diffractions, NMR ECD calculations. Among these atypical angucyclinones, compound 1 represented first seven-membered ketoester in angucyclinone family, which sheds light on origin of...
Abstract A new 1,3‐dihydroisobenzofuran derivative ( 1 ), together with its epimer 2 was isolated from marine Streptomyces sp. W007. The structure of the two compounds established by extensive spectroscopic analysis and comparison reported data. absolute configurations were determined a combination experimental computational means, including J ‐coupling nuclear Overhauser effect spectroscopy (NOESY) spectra, magnetic resonance (NMR) calculations, electronic circular dichroism (ECD), optical...
Abstract (±)‐Pratenone A ( 1 ), the first representative of natural 3‐(1‐naphthyl)‐2‐benzofuran‐1(3H)‐one polyketides, was isolated from a marine‐derived Streptomyces pratensis strain KCB‐132 together with three other new analogues 2−4 ). Its structure assigned by spectroscopic analysis, and absolute configurations two enantiomers separated high‐performance liquid chromatography were determined single‐crystal X‐ray diffraction electronic circular dichroism calculations. The solvent‐induced...
First Asp-containing actinomycin and two unusual tetracyclic chromophoric analogues with potent cytotoxic antibacterial activities from marine-derived Streptomyces sp. strain S22.