A5115602692- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Cancer Mechanisms and Therapy
- Ocular Oncology and Treatments
- Optical Coherence Tomography Applications
- Mechanisms of cancer metastasis
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Effects and risks of endocrine disrupting chemicals
- Corneal surgery and disorders
- Peptidase Inhibition and Analysis
- Ocular and Laser Science Research
- Antimicrobial Resistance in Staphylococcus
- Circular RNAs in diseases
- Bacterial Identification and Susceptibility Testing
- Cancer-related Molecular Pathways
- Corneal Surgery and Treatments
- Psoriasis: Treatment and Pathogenesis
- Migraine and Headache Studies
- Drug-Induced Ocular Toxicity
- Cytokine Signaling Pathways and Interactions
- Ocular Infections and Treatments
Tianjin Medical University
2012-2025
Nankai University
2020-2024
Tianjin Medical University Eye Hospital
2016-2024
Beijing Tongren Hospital
2022
Qingdao Municipal Hospital
2022
Qingdao University
2022
Wenzhou Medical University
2022
Chinese University of Hong Kong
2022
Nanjing Medical University
2021
Shanxi Medical University
2017-2020
Abstract SND1 is an AEG-1/MTDH/LYRIC-binding protein that upregulated in numerous human cancers, where it has been assigned multiple functional roles. In this study, we report its association with the TGFβ1 signaling pathway, which promotes epithelial–mesenchymal transition (EMT) breast cancer. was cancer tissues, particular primary invasive ductal carcinomas. Transcriptional activation of gene controlled by TGFβ1/Smad specifically Smad2/Smad3 complex. The promoter region contained several...
Tudor staphylococcal nuclease (Tudor-SN) is a multifunctional protein implicated in variety of cellular processes. In the present study, we identified Tudor-SN as novel regulator cell cycle. was abundant proliferating cells whereas barely expressed terminally differentiated cells. Functional analysis indicated that ectopic overexpression promoted G1/S transition, knockdown caused G1 arrest. Moreover, live-cell time-lapse experiment demonstrated cycle MEF(-/-) (knock-out mouse embryonic...
Background: Radiotherapy is one of the most effective therapeutic strategies for cervical cancer patients, although radioresistance-mediated residual and recurrent tumors are main cause treatment failure. However, mechanism tumor radioresistance still elusive. DNA damage response pathways key determinants radioresistance. The purpose this study was to investigate role SND1 in cancer. Methods: A stable HeLa cell line with knockout (HeLa-KO) generated through a modified CRISPR/Cas9...
Cancer immunoediting is defined as the integration of immune system's dual host-protective and tumor-promoting roles, including three phases: elimination, equilibrium, escape. Immune selective pressure causes tumor cells to lose major histocompatibility complex expression or acquire immunosuppressive gene expression, which promotes evasion progression. Interleukin-17D (IL-17D), a member IL-17 family cytokines, plays an important role in host defense against infection inflammation. However,...
Importance The global prevalence of myopia has shown a steady increase over recent decades, with urban areas seemingly experiencing more significant impact. Objective To assess the association between urbanization and prevalence, incidence, progression, severity myopia. Design, Setting, Participants This cohort study included students in grades 1 to 6 Tianjin, China, who underwent 3 vision examinations conducted 2-year period, from March 1, 2021, 31, 2023. 4 completed follow-up. Exposures...
Abstract To investigate the effects of a high-fat diet (HFD) and apolipoprotein E ( Apoe ) deficiency on retinal structure function in mice. KO mice wild-type C57BL/6J were given low-fat (LFD) or HFD for 32 weeks. Blood glucose, serum lipids, body weight visceral fat evaluated. Retinal sterol quantification was carried out by isotope dilution gas chromatography-mass spectrometry. The cholesterol metabolism related genes SCAP-SREBP expressions detected qRT-PCR. recorded using an...
Abstract Background Oxidative stress can induce age-related diseases. Age-related retinal diseases, such as macular degeneration (AMD), are difficult to cure owing their complicated mechanisms. Although anti-neovascular therapeutics used treat wet AMD, vision cannot always be completely restored, and disease progression inhibited. Therefore, determining a method prevent or slow damage is important. This study aimed investigate the protective effect of chrysanthemum water extract rich in...
// Liwen Jin 1, * , Wei Zhang 2, 3, Hong Pan 3 Tengyan Li 2 Beihong Liu Junyang Zhao 4 and Binbin Wang 1 Department of Ophthalmology, Maternal Children's Hospital, Quanzhou, Fujian, China Center for Genetics, National Research Institute Family Planning, Beijing, Graduate School Peking Union Medical College, Beijing Capital University, These authors contributed equally to this work Correspondence to: Wang, email: wbbahu@163.com Zhao, zhaojunyang@163.com Keywords: retinoblastoma, retrospective...
Malonate, a classic inhibitor of respiratory electron transport chain, induces mitochondrial stress. Stress granules ( SG s) are kind dynamic foci structure during The study on the connection stress and assembly is still limited. Here, we demonstrated that malonate treatment leads to formation translation inhibition, apart from stress, including enhanced ROS formation, reduced Δψ m ATP level. phosphorylation levels eIF 2α 4 EBP 1 protein were affected upon dysfunction. However, knockdown...
Objective: To investigate ocular development and the characteristics of visual function among children with cerebral palsy (CP) intellectual disabilities in Beijing's Chaoyang District schools. Methods: A total 160 (320 eyes) CP disabilities, including 86 males 74 females aged between 6 18 years old (median, 13.5 years), were included this study. 214 healthy to 10 years) recruited as a control group for function, 116 98 females. Subjective far vision, objective vision (electrophysiological...
Abstract Background Kidney and eye diseases may be closely linked. Tears of the retinal pigment epithelium (RPE) have been reported to related kidney diseases, such as IgA nephropathy light-chain deposition disease. However, tears associated with membranous not or systematically analysed. Case presentation A 68-year-old man presented decreased right visual acuity. Optical coherence tomography (OCT) revealed cystic macular edema, localized serous detachment retina loss outer structure in...
An increasing prevalence of mental disorders (MDs) has been reported among children and adolescents. However, only few studies have conducted ocular examinations, including those on refractive status, in these groups patients. Thus, the purpose this study was to evaluate status findings adolescents with MDs compared matched controls similar socioeconomic backgrounds.A total 178 participants 200 were recruited between April 2021 May 2022. All underwent cycloplegic or noncycloplegic...
To report the efficacy of a bleb-independent penetrating canaloplasty in management glaucoma secondary to iridocorneal endothelial syndrome (GS-ICE).Prospective, non-comparative clinical study.Penetrating was performed on 35 eyes from patients with GS-ICE and medically uncontrolled intraocular pressure (IOP) between January 2018 April 2020. Patients were followed up at 1 week, months 1, 3, 6, 12 postoperatively, semi-annually thereafter. The IOP, anti-glaucoma medication, surgery-related...
Serum levels of amino acids related to urea cycle are associated with risk type 2 diabetes mellitus (T2DM). Our study aimed explore whether serum cycle, i.e., arginine, citrulline, and ornithine, also increased chronic kidney disease (CKD) in T2DM. We extracted medical records 1032 consecutive patients T2DM from the Electronic Administrative System Liaoning Medical University First Affiliated Hospital (LMUFAH) system May 2015 August 2016. Of them, 855 completed data available were used...
Retinoblastoma (RB) is a common intraocular malignant tumor in infants and young children. However, reports on the morphological descriptions of RB cells from native foreign scholars are rare.To investigate myelogram characteristics with extraocular extension bone marrow cerebrospinal fluid.For period May 2011 to February 2015, we analyzed clinical data 18 patients our hospital diagnosed as having metastatic other distant regions associated clear metastasis. The morphology fluid was...
Background The characteristics of eye movement waveforms in congenital nystagmus eyes is so complicated that the time-series waveform can hardly demonstrate oscillational kinetic property nystagmus, which not convenient for clinical diagnosis and evaluation.The system a nonlinear feedback control system, phase portrait analysis useful method describing system. Objective This study was to establish provide new technique evaluation nystagmus. Methods A prospective series-case...