A5018345618- Animal Virus Infections Studies
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Assisted Reproductive Technology and Twin Pregnancy
- Bacteriophages and microbial interactions
- Ovarian function and disorders
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- melanin and skin pigmentation
- interferon and immune responses
- Cutaneous lymphoproliferative disorders research
- Tea Polyphenols and Effects
- Hepatitis Viruses Studies and Epidemiology
- Reproductive Health and Technologies
- Cancer Mechanisms and Therapy
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
Shanghai Jiao Tong University
2024
International Peace Maternity & Child Health Hospital
2024
Pennsylvania State University
2018-2022
China Agricultural University
2014-2018
University of Minnesota
2014
Jiangsu Province Hospital
2006
Nanjing Medical University
2006
Air Force Medical University
2003
Xijing Hospital
2003
Baylor College of Medicine
1989
The loss of detectable hepatitis B surface antigen (HBsAg) is considered a functional cure in chronic B. Naturally, HBsAg can be incorporated into the virion envelope or assembled subviral particles (SVPs) with lipid from host cells. Until now, there has been no detailed structure HBsAg, and published SVP structures are controversial. Here, we report first subnanometer-resolution spherical virus (HBV) related woodchuck (WHV) determined by cryo–electron microscopy combination AlphaFold2...
Hepatitis B virus (HBV) core protein (HBc) contains an N-terminal domain (NTD, assembly domain) and a C-terminal (CTD), which are linked by flexible linker region. HBc plays multiple essential roles in viral replication, including capsid assembly, packaging of the pregenomic RNA (pgRNA) into nucleocapsids, reverse transcription that converts pgRNA to genomic DNA, secretion DNA-containing (complete) virions or genome-free (empty) virions. The is generally assumed act merely as spacer between...
Hepatitis B virus (HBV) delivers a partially double-stranded, relaxed circular (RC) DNA genome in complete virions to the host cell nucleus for conversion covalently closed (CCC) DNA, which establishes and sustains viral infection. An overlength pregenomic RNA (pgRNA) is then transcribed from CCC packaged into immature nucleocapsids (NCs) by core (HBc) protein. pgRNA reverse produce RC mature NCs, are enveloped secreted as virions, or delivered replenish nuclear pool. whether originating...
Hepatitis B virus (HBV) capsid or core protein (HBc) contains an N-terminal domain (NTD) and a C-terminal (CTD) connected by short linker peptide. HBc plays critical role in virtually every step of viral replication, which is further modulated dynamic phosphorylation dephosphorylation its CTD. While several cellular kinases have been identified that mediate CTD phosphorylation, there little information on the phosphatases dephosphorylation. Herein, consensus binding motif for phosphatase 2A...
Hepatitis B virus (HBV) is an important global human pathogen and persistently infects hundreds of millions people, who are at high risk cirrhosis liver cancer. HBV capsid packages a host cell protein kinase, the cyclin-dependent kinase 2 (CDK2), which thought to be required trigger disassembly viral nucleocapsid during infection by phosphorylating protein, prerequisite for successful infection.
Hepatitis B virus (HBV) is a major human pathogen causing serious liver diseases, including cancer. Interactions between the HBV capsid and large (L) envelope protein are required for formation of infectious viral particles also negatively regulate an DNA episome in host cell nucleus, which serves as sole transcriptional template capable supporting all gene expression to sustain replication and, therefore, molecular basis persistence.
A method of in situ hybridization using single-stranded RNA probes opposite polarity for quantitative enumeration hepatitis virus (HAV) infected cells has been developed. Kinetic experiments showed that foci appeared as early day 2 postinfection. The absence examined immediately after adsorption indicated detected subsequently were related to viral replication. Foci by with complementary HAV genomic but not identical RNA. number observed was linearly the dose inoculated. Focus formation...
Hepatitis B virus (HBV) contains a partially double-stranded, relaxed circular (RC) DNA genome synthesized within nucleocapsid (NC) in the host cell cytoplasm. The release of RC from NC, an ill-defined process called uncoating, to nucleus is required for its conversion covalently closed (CCC) DNA, viral episome serving as transcriptional template all RNAs necessary replication and, thus, essential establishing and sustaining infection. In efforts better understand we analyzed HBV core (HBc)...
Abstract Purpose The study aimed to investigate the potential influence of COVID-19 infection on embryo implantation and early development in women undergoing frozen transfer (FET), with a specific focus infections occurring at different periods around FET. Methods A retrospective analysis was performed who had undergone FET during period marked by significant surge Shanghai. All enrolled experienced their first documented time FET, ensuring that did not occur prior oocyte retrieval....
The avian influenza virus (AIV) causes frequent disease with high morbidity and mortality. RNA interference (RNAi) has been shown to provide an effective antiviral defense in animals, several studies have focused on harnessing small interfering RNAs (siRNAs) inhibit viral infections. In addition, single chain variable fragments (scFvs) contain the complete antigen binding site, specific scFvs can bind neutralize viruses. Fourteen positive were selected by yeast two-hybrid system. Using...