A5101687417- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Respiratory Support and Mechanisms
- Multiple Myeloma Research and Treatments
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Prostate Cancer Treatment and Research
- S100 Proteins and Annexins
- Biomarkers in Disease Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- HIV Research and Treatment
- Neuroscience of respiration and sleep
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
First Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
Pennsylvania State University
2017-2020
McGill University Health Centre
2002
Hepatitis B virus (HBV) covalently closed circular (CCC) DNA functions as the only viral template capable of coding for all RNA species and is thus essential to initiate sustain replication. CCC converted, in a multistep ill-understood process, from relaxed (RC) DNA, which neither two strands closed. To detect putative intermediates during RC conversion, 3' exonucleases, exonuclease I (Exo I) Exo III, were used combination degrade with free end, would nevertheless preserve either...
Little is known about the structural response of diaphragm to controlled mechanical ventilation. We examined effects this intervention on muscle mass, myosin heavy chain isoforms, and contractile function in rat diaphragm. Animals were mechanically ventilated for up 4 days, comparisons made with normal control rats as well spontaneously breathing animals anesthetized same duration ventilation group. The diaphragm-to-body weight ratio was significantly reduced group only. After ventilation,...
Hepatitis B virus (HBV) delivers a partially double-stranded, relaxed circular (RC) DNA genome in complete virions to the host cell nucleus for conversion covalently closed (CCC) DNA, which establishes and sustains viral infection. An overlength pregenomic RNA (pgRNA) is then transcribed from CCC packaged into immature nucleocapsids (NCs) by core (HBc) protein. pgRNA reverse produce RC mature NCs, are enveloped secreted as virions, or delivered replenish nuclear pool. whether originating...
The covalently closed circular (CCC) DNA of hepatitis B virus (HBV) functions as the only viral transcriptional template capable producing all RNA species and is essential to initiate sustain replication. CCC converted from a relaxed (RC) DNA, in which neither two strands closed. As RC mimics damaged cellular host cell damage repair (DDR) system thought be responsible for HBV formation. potential role major DDR pathways, ataxia telangiectasia mutated (ATM) pathway ATM Rad3-related (ATR)...
The increase in the number of thyroid cancer cases recent years has increased not only medical burden but also potential for overtreatment. Therefore, it is crucial to distinguish papillary from benign nodules before surgery when treating nodules.The patients were divided into two groups: 117 made up validation cohort and 414 primary cohort. As a result cohort, preoperative prediction model was developed, which then validated externally Preoperative thyrotropin (thyroid stimulating hormone,...
<div>Abstract<p>The enhancer pioneer transcription factor FoxA1 is a global mediator of steroid receptor (SR) action in hormone-dependent cancers. In castration-resistant prostate cancer (CRPC), acts as an androgen cofactor to drive G<sub>2</sub> M-phase cell-cycle transit. Here, we describe mechanistically distinct SR-independent role for driving G<sub>1</sub> S-phase transit CRPC. By comparing binding sites cell genomes, defined codependent set...