A5059935776- Hepatitis B Virus Studies
- Hepatitis C virus research
- Stellar, planetary, and galactic studies
- Astronomy and Astrophysical Research
- Adaptive optics and wavefront sensing
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Astronomical Observations and Instrumentation
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Viral Infections and Vectors
- Calibration and Measurement Techniques
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- HIV Research and Treatment
- Superconducting and THz Device Technology
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Immunotherapy and Immune Responses
- Polar Research and Ecology
- Virus-based gene therapy research
- Plant Virus Research Studies
- Virology and Viral Diseases
University of Hong Kong
2018-2025
Hainan Medical University
2018-2025
Ministry of Education of the People's Republic of China
2023
Pennsylvania State University
2013-2022
Institute of Deep-Sea Science and Engineering
2022
Chinese Academy of Sciences
2022
Peking Union Medical College Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Peking University Shougang Hospital
2022
Nanjing Institute of Astronomical Optics & Technology
2006-2017
Rocahepevirus ratti (rat hepatitis E virus; rHEV) is a ubiquitous pathogen of rats that has recently emerged as cause in humans. Although several rHEV cases have been detected worldwide, the extent human exposure to this agent still poorly defined. We conducted multicenter surveillance study China examining exposures demographically diverse populations from One Health perspective. In cross-sectional study, we used fully validated IgG enzymatic immunoassays and reverse transcription PCR 1,199...
We present the second release of value-added catalogues LAMOST Spectroscopic Survey Galactic Anticentre (LSS-GAC DR2). The values radial velocity $V_{\rm r}$, atmospheric parameters --- effective temperature $T_{\rm eff}$, surface gravity log$g$, metallicity [Fe/H], $\alpha$-element to iron (metal) abundance ratio [$\alpha$/Fe] ([$\alpha$/M]), elemental abundances [C/H] and [N/H], absolute magnitudes ${\rm M}_V$ M}_{K_{\rm s}}$ deduced from 1.8 million spectra 1.4 unique stars targeted by...
The mature nucleocapsid (NC) of hepatitis B virus containing the relaxed circular (RC) DNA genome can be secreted extracellularly as virions after envelopment with viral surface proteins or, alternatively, disassembled to release RC (i.e., uncoating) into host cell nucleus form covalently closed (CCC) DNA, which sustains replication and persistence. In contrast, immature NCs single-stranded or pregenomic RNA are incompetent for either uncoating. Little is currently known about how NCs, not...
Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as transcriptional template for all viral RNAs. CCC DNA is converted from relaxed (RC) in virion early during infection well RC intracellular progeny nucleocapsids via an amplification pathway. Current antiviral therapies suppress but cannot eliminate DNA. Thus, of remains obstacle toward curing chronic HBV infection. Unfortunately, very little known...
Hepatitis B virus (HBV) covalently closed circular (CCC) DNA functions as the only viral template capable of coding for all RNA species and is thus essential to initiate sustain replication. CCC converted, in a multistep ill-understood process, from relaxed (RC) DNA, which neither two strands closed. To detect putative intermediates during RC conversion, 3' exonucleases, exonuclease I (Exo I) Exo III, were used combination degrade with free end, would nevertheless preserve either...
The domes, or local elevation maxima, on the Antarctic plateau provide a unique opportunity for ground-based astronomy in that turbulent boundary layer is so thin telescope small tower can be free atmosphere, i.e., portion of atmosphere which turbulence decoupled from effect Earth's surface. There, it enjoy itself appears to offer superior conditions temperate sites. This breaks problem characterizing at sites into two separate tasks: determining variability, distribution and thickness...
We present the first direct measurements of terahertz atmospheric transmission above Dome A, highest point on Antarctic plateau at an elevation 4.1 km. The best-quartile during Austral winter is 80% a frequency 661 GHz (453 μm), corresponding to precipitable water vapor column 0.1 mm. Daily averages as low 0.025 mm were observed. atmosphere very stable, and excellent observing conditions generally persist for many days time. exceptional over high open new far-infrared spectral windows...
ABSTRACT Hepatitis B virus (HBV) infects hundreds of millions people worldwide and causes acute chronic hepatitis, cirrhosis, hepatocellular carcinoma. HBV is an enveloped with a relaxed circular (RC) DNA genome. In the nuclei infected human hepatocytes, conversion RC from incoming virion or cytoplasmic mature nucleocapsid (NC) to covalently closed (CCC) DNA, which serves as template for producing all viral transcripts, essential establish sustain replication. For reasons yet be understood,...
ABSTRACT Assembly of hepatitis B virus (HBV) begins with packaging the pregenomic RNA (pgRNA) into immature nucleocapsids (NC), which are converted to mature NCs containing genomic relaxed circular (RC) DNA as a result reverse transcription. Mature have two alternative fates: (i) envelopment by viral envelope proteins, leading secretion extracellularly virions, or (ii) disassembly (uncoating) deliver their RC content host cell nucleus for conversion covalently closed (CCC) DNA, template How...
Hepatitis B virus (HBV) infects hundreds of millions people worldwide and causes acute chronic hepatitis, cirrhosis, hepatocellular carcinoma. HBV is an enveloped with a relaxed circular (RC) DNA genome. In the nuclei infected human hepatocytes, conversion RC from incoming virion or cytoplasmic mature nucleocapsid (NC) to covalently closed (CCC) DNA, which serves as template for producing all viral transcripts, essential establish sustain replication. A prerequisite CCC formation uncoating...
Parvoviruses are a diverse group of viruses that capable infecting wide range animals. In this study, we report the discovery novel parvovirus, tilapia parvovirus HMU-HKU, in fecal samples crocodiles and intestines Hainan Province, China. The was firstly identified from fed with using next-generation sequencing (NGS). Screening studies revealed prevalence crocodile feces on (75-86%) apparently higher than chicken (4%). Further collected at four areas Province between 40 90%. Four stains were...
Throughout the COVID-19 pandemic, rhinovirus (RV) remained notable persistence, maintaining its presence while other seasonal respiratory viruses were largely suppressed by pandemic restrictions during national lockdowns. This research explores epidemiological dynamics of RV infections among pediatric populations on Hainan Island, China, specifically focusing impact before and after zero-COVID policy was lifted. From January 2021 to December 2023, 19 680 samples collected from patients...
The PLATeau Observatory (PLATO) is an automated self-powered astrophysical observatory that was deployed to Dome A, the highest point on Antarctic plateau, in 2008 January. PLATO consists of a suite site-testing instruments designed quantify benefits A site for astronomy, and science take advantage unique observing conditions. Instruments include CSTAR, array optical telescopes transient astronomy; Gattini, instrument measure sky brightness cloud cover statistics; DASLE, experiment...
We introduce ART, a distribution-free and model-agnostic framework for changepoint detection that provides finite-sample guarantees. ART transforms independent observations into real-valued scores via symmetric function, ensuring exchangeability in the absence of changepoints. These are then ranked aggregated to detect distributional changes. The resulting test offers exact Type-I error control, agnostic specific or model assumptions. Moreover, seamlessly extends multi-scale settings,...
Background: During the COVID-19 pandemic, we continuously monitored epidemiology of influenza virus among pediatric patients from January 2021 to December 2023 in Hainan Island, China. Methods: In this study, collected 54,974 nasopharyngeal swab samples for A Virus (IAV) testing and 53,151 B (IBV) outpatients. Additionally, also 19,687 inpatients IAV IBV testing. Outpatient were screened viruses (IVs) infection by colloidal gold method. Targeted Next-Generation Sequencing (tNGS) was used...
Eld's deer (Rucervus eldii) is a rare and globally endangered tropical Southeast Asian species. There no research on pathogens in Hainan, China. This study aimed to understand the virus diversity novel viruses deer, provided important epidemiological baseline information for conservation of this 33 nasal swabs, anal 9 wound (bitten by ticks) swabs were collected from wild nature reserve which constituted into 5 pools. Based next-generation sequencing (NGS) macrogenomic analysis, there...
Human parainfluenza viruses (HPIVs) are the leading causes of acute respiratory tract infections (ARTIs), particularly in children. During COVID-19 pandemic, non-pharmaceutical interventions (NPIs) significantly influenced epidemiology viruses. This study analyzed 19,339 specimens from pediatric patients with ARTIs to detect HPIVs using PCR or tNGS, focusing on period 2021 2023. were identified 1395 (7.21%, 1395/19,339), annual detection rates 6.86% (303/4419) 2021, 6.38% (331/5188) 2022,...
Over a decade of site testing in Antarctica has shown that both South Pole and Dome C are exceptional sites for astronomy, with certain atmospheric conditions superior to those at existing mid-latitude sites. However, the highest point on Antarctic plateau, A, is expected experience colder temperatures, lower wind speeds, turbulent boundary layer confined closer ground. The Polar Research Institute China, who were first visit A January 2005, plan establish permanently manned station there...
In January 2005, members of a Chinese expedition team were the first humans to visit Dome A on Antarctic plateau, site predicted be one very best astronomical sites earth. 2006, Center for Astronomy (CCAA) was founded promote development astronomy in Antarctica, especially at A. CCAA has since taken part two traverses A, organized by Polar Research Institute China (PRIC), austral summers 2007/2008 and 2008/2009. These resulted installation many site-testing science instruments, supported...
Astroviruses infect human and animals cause diarrhea, fever, vomiting. In severe cases, these infections may be fatal in infants juvenile animals. Previous evidence showed that humans contact with infected can develop serological responses to astroviruses. Mamastrovirus 11 is a species of was first reported 2018. It detected the fecal samples California sea lion. The genome sequence its capsid protein (CP) submitted GenBank. However, non-structural region not elucidated. present study, we...
Pre-HEAT is a 20 cm aperture submillimeter-wave telescope with 660 GHz (450 micron) Schottky diode heterodyne receiver and digital FFT spectrometer for the Plateau Observatory (PLATO) developed by University of New South Wales. In January 2008 it was deployed to Dome A, summit Antarctic plateau, as part scientific traverse led Polar Research Institute China Chinese Academy Sciences. A may be one best sites in world ground based Terahertz astronomy, on exceptionally cold, dry stable...
The risk of emerging infectious diseases (EID) is increasing globally. More than 60% EIDs worldwide are caused by animal-borne pathogens. This study aimed to characterize the virome, analyze phylogenetic evolution, and determine diversity rodent-borne viruses in Hainan Province, China. We collected 682 anal throat samples from rodents, combined them into 28 pools according their species location, processed for next-generation sequencing bioinformatics analysis. diverse viral contigs closely...