In most previous studies, it has been difficult for a robot hand to regrasp target quickly because its motion was static or quasi-static, in constant contact state. order achieve high-speed regrasping, we propose new strategy which call dynamic regrasping. this strategy, the regrasping task is achieved by throwing up and catching it. paper, based on visual feedback presented experimental results using multifingered vision system are shown. A cylinder chosen as specific example of with...

Intracellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) depends on the interaction between its spike protein with cellular receptor angiotensin-converting enzyme (ACE2) and Furin-mediated cleavage priming by host cell proteases, including transmembrane protease serine (TMPRSS2). As expression ACE2, TMPRSS2, Furin in middle inner ear remain unclear, we analyzed these proteins mouse tissues.Animal Research.We performed immunohistochemical analysis to examine...

Objective Patients with coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome 2 (SARS‐CoV‐2), exhibit not only symptoms but also of chemo‐sensitive disorders. Cellular entry SARS‐CoV‐2 depends on the binding its spike protein to a cellular receptor named angiotensin‐converting enzyme (ACE2), and subsequent protein‐priming host cell proteases, including transmembrane protease serine (TMPRSS2). Thus, high expression ACE2 TMPRSS2 is considered enhance invading...

Objectives: This study aimed to determine the positive predictive value of our NMD Suspicion Criteria in diagnosis NMDs. Other clinical factors routinely examined voice and swallowing examinations were also investigated see if they had a significant association with Methods: retrospectively medical charts patients who visited Voice Swallowing outpatient clinic between 2013 2022. Patients previously diagnosed NMDs excluded from analysis. Among remaining patients, we included those that...

Abstract Objective To investigate the effects of modified central‐part laryngectomy with pharyngeal space reduction (CPL‐PR) on patients weak deglutitive contraction, as seen in late‐stage amyotrophic lateral sclerosis (ALS). Study Design Retrospective case series. Setting Single‐institution academic center. Methods Patients ALS confined at The University Tokyo Hospital between 2019 and March 2024 whom CPL‐PR had been performed were identified. who undergone simultaneous flap surgery or no...

In recent years, the use of aspiration prevention surgery (APS) for treatment severe dysphagia has been on rise. However, relevant clinical studies have included small samples, and frequency of, risk factors postoperative complications not clarified. We investigated features patients undergoing APS whether oral-intake status suction could be reduced.A case series.Single-institution academic center.We retrospectively evaluated medical charts generated from 2010 to 2021. The characteristics...

Abstract Purpose To discuss the different swallowing improvement surgeries that address one or more dysfunctional pharyngolaryngeal structures causing dysphagia. These reduce risk of aspiration without sacrificing vocal function. Methods We searched PubMed database and used Google Scholar search engine to find studies discussing surgeries. A manual references in selected articles reviews was done as well. No chronologic limitation set for studies; however, only written English Japanese were...

Vocal fold motion impairment (VFMI) is the inappropriate movement of vocal folds during respiration, leading to adduction and/or abduction problems and causing respiratory impairments. Neurodegenerative diseases (NDDs) are a wide range disorders characterized by progressive loss neurons deposition altered proteins in brain peripheral organs. VFMI may be unrecognized patients with NDDs. NDDs caused following: laryngeal muscle weakness due muscular atrophy, brainstem motor neuron degeneration...

Objectives/Hypothesis Unilateral vocal fold paralysis (UVFP) induces hoarseness due to progressive atrophy of the denervated thyroarytenoid (TA) muscle. Therefore, treatments aimed at regenerating atrophied TA muscle are required. Basic fibroblast growth factor (bFGF) is involved in development and regeneration. This study elucidate effects bFGF injection on Study Design Animal research. Methods A recurrent laryngeal nerve–paralysis rat model was established, low‐ (200 ng) or high‐dose...

Introduction: Multiple system atrophy (MSA) has detrimental effects on swallowing function. The function of patients with MSA not been systematically characterized and the underlying pathophysiological mechanisms dysphagia remain poorly understood. Objectives: To investigate characteristics swallow in using high-resolution manofluorography (HRMF). Methods: We conducted a retrospective review twenty-five who underwent HRMF from 2016 to 2017. was utilized only oral diet (Functional Oral Intake...

Objectives/Hypothesis Contrast agent (CA) aspiration is an established complication of upper gastrointestinal and videofluoroscopic swallow studies. The underlying molecular biological mechanisms acute response to CA in the respiratory organs remain unclear. aims this study were elucidate histological influences three kinds CAs on lung clarify differences responses. Study Design Animal model. Methods Eight‐week‐old male Sprague Dawley rats divided into five groups (n = 6 each group). Three...

Abstract Objective Patients with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), exhibit not only symptoms but also of chemo-sensitive disorders and kidney failure. Cellular entry SARS-CoV-2 depends on the binding its spike protein to a cellular receptor named angiotensin-converting enzyme (ACE2), subsequent protein-priming host cell proteases, including transmembrane protease serine (TMPRSS2). Thus, high expression ACE2 TMPRSS2 are considered...

Dysphagia, one of the major complications neuromuscular diseases such as Parkinson's disease and amyotrophic lateral sclerosis (ALS), decreases quality life may lead to malnutrition or aspiration pneumonia. Although recent reports have suggested that surgical prevention improves enables oral intake, selection appropriate techniques has rarely been discussed. In this report, we present cases three patients with who underwent prevention; selected based on analysis dysphagia mechanisms,...

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder. Since patients with MSA often have sleep-related respiratory disorders including upper-airway obstruction and/or central sleep disturbance, appropriate evaluation of the upper airway especially during may be indispensable. Fiberoptic laryngoscopy diazepam-induced has been reported for verification. However, some cannot endure uncomfortable sensation fiberscope. To address these issues, we devised protocol four...

Abstract Objectives Intracellular entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) depends on interaction between its spike protein to a cellular receptor named angiotensin-converting enzyme (ACE2) and Furin-mediated 23 cleavage priming by host cell proteases including 24 transmembrane protease serine (TMPRSS2). Tmprss1, Tmprss3, Tmprss5 are expressed in spiral ganglion neurons organ Corti inner ear; however, Ace2, Tmprss2, Furin expression profiles middle ear remain...

Oral intake after aspiration prevention surgery (APS) is influenced by postoperative pharyngeal pressure and the dynamics of upper esophageal sphincter (UES). We examined effects less invasive APS combined with UES relaxation techniques (laryngeal closure cricopharyngeal myotomy [LC-CPM] central-part laryngectomy [CPL]) on dynamics.Retrospective, observational study.Single center.We assessed high-resolution manometric parameters patients who underwent from 2018 to 2020. Then, we compared...

Objectives Esophageal dysmotility (ED) in patients with multiple system atrophy (MSA) are poorly understood. This study aimed to investigate the prevalence of ED MSA and assess relationship esophageal abnormalities other clinical findings characteristics these patients. Methods A retrospective chart review was conducted identify compare them elderly controls without (65+ years) who underwent a videofluorographic esophagram from 2014 2019. Disease type, disease severity, vocal fold mobility...

Systemic sclerosis (SSc) is often associated with dysphagia and esophageal dysmotility; however, only a few clinical studies on this topic have been conducted. Patients SSc who underwent swallowing examinations esophagography at our institution between 2010 2022 were included. A retrospective evaluation of the patients' backgrounds, autoantibody positivity, function, motility was performed using medical charts. The association dysmotility in patients respective risk factors investigated....

Research on regenerative medicine using basic fibroblast growth factor (bFGF) has recently advanced in the field of laryngology. We previously reported that local administration bFGF 1 month after recurrent laryngeal nerve (RLN) paralysis compensated for atrophy thyroarytenoid muscle. The objective this study was to elucidate effects early muscle RLN transection and investigate underlying mechanisms.A rat model established study. One day transection, low- (200 ng) or high-dose (2000 saline...