A5102845746- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Aerospace and Aviation Technology
- Insect symbiosis and bacterial influences
- Adaptive Control of Nonlinear Systems
- Mosquito-borne diseases and control
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Immune cells in cancer
- Computational Fluid Dynamics and Aerodynamics
- Plasma and Flow Control in Aerodynamics
- Guidance and Control Systems
- HER2/EGFR in Cancer Research
- Underwater Acoustics Research
- Underwater Vehicles and Communication Systems
- Advanced Control Systems Optimization
- Industrial Technology and Control Systems
- interferon and immune responses
- Advanced Breast Cancer Therapies
- Traffic Prediction and Management Techniques
- Sustainable Building Design and Assessment
- Aeroelasticity and Vibration Control
- Aerodynamics and Fluid Dynamics Research
- Cancer Immunotherapy and Biomarkers
Nanjing University
2023-2024
Chongqing University of Science and Technology
2024
Tianjin University
2024
Fujian Agriculture and Forestry University
2023-2024
Anhui University
2023
Ministry of Agriculture and Rural Affairs
2023
Northwestern Polytechnical University
2019-2022
Hebei University of Technology
2011
Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, reduce for wound treatment is presented. These findings reveal Ag/PDAs exhibit broad‐spectrum...
Abstract In situ tumor vaccines (ISTVs) hold great potential in immunotherapy, however, three major obstacles, including inadequate endogenous antigen uptake by dendritic cells (DCs), weak T‐cell immune responses, and stubborn immunosuppressive microenvironment (TME), still need to be fully addressed. Herein, a trifecta nanovaccine (TriNV) with TME‐responsive transformable ability is developed tri‐boost antitumor immunity. First, sufficient tumor‐associated antigens (TAAs) are liberated...
Background: Nanovaccines have emerged as a promising vaccination strategy, exhibiting their capacity to deliver antigens and adjuvants elicit specific immune responses. Despite this potential, optimizing the design delivery of nanovaccines remains challenge. Methods: In study, we engineered dendritic mesoporous silica-based nanocarrier enveloped in metal-phenolic network (MPN) layer containing divalent manganese ions tannic acid (MSN@MT). This was tailored for antigen loading serve...
The dense extracellular matrix (ECM) in the tumor microenvironment forms an abnormal physical barrier, which impedes delivery and penetration of nanomedicines hinders their therapeutic efficacy. Herein, we synthesize matrix-degrading soft-nanocapsules composed human serum albumin (HSA) hyaluronidase (HAase) for overcoming obstruction ECM microenvironment. albumin/hyaluronidase soft-nanocapsules, referred to as HSA/HAase SNCs, possess a uniform diameter, inward hollow structure, wrinkled morphology.
The development of nanovaccines capable eliciting tumor-specific immune responses holds significant promise for tumor immunotherapy. However, many nanovaccine designs rely heavily on incorporating multiple adjuvants and carriers, increasing the biological hazards associated with these additional components. Here, this work introduces novel flexible nanocapsules (OVAnano) designed to mimic extracellular vesicles, primarily using ovalbumin antigen minimal polyethylenimine adjuvant These...
The aerodynamic layout of the Canard Rotor/Wing (CRW) aircraft in helicopter flight mode differs significantly from that conventional helicopters. In order to study dynamics characteristics CRW mode, first, model main rotor system is established based on blade element theory and wind tunnel test results. forces moments canard wing, horizontal tail, vertical tail fuselage are obtained via theoretical analysis empirical formula. developed validated by data. Next, a method trimming using an...
This paper proposes an adaptive fault-tolerant control strategy for a hybrid vertical take-off and landing (VTOL) unmanned aerial vehicle (UAV) to simultaneously compensate actuator faults model uncertainties. With the proposed schemes, both uncertainties can be accommodated without knowledge of fault information uncertainty bounds. The scheme is constructed with two separate modules. low-level allocation module used distribute virtual signals among available redundant actuators. high-level...
Nanovaccines In article number 2311480, Yongbin Mou, Zhaogang Teng, Heng Dong, and co-workers present a tumor microenvironment-responsive soft-transformable nanovaccine that comprehensively addresses the major obstacles faced by in situ vaccines. It includes promoting immunogenic cell death cells, fostering dendritic maturation, encouraging macrophage M1 polarization, all while reprogramming immunosuppressive microenvironment.
Abstract Antibacterial therapy targeting the regulation of macrophage polarization may be a useful approach for normalizing immune environment and accelerating wound healing. Inspired by black phosphorus‐based nanoplatforms, more stable yet less‐explored violet phosphorus nanosheets (VPNSs) are expected to provide superior solution effectively combating bacterial infections. In this study, an average thickness 5–7 nm VPNSs fabricated through liquid‐phase exfoliation method serve as...
Individuals with abnormalities are key drivers of subtle stress changes in forest ecosystems. Although remote sensing monitoring and deep learning have been developed for ecosystems, they faced the complexity landscapes, multiple sources data, high costs, complex terrain, which pose significant challenges to automatic identification. Therefore, taking pine nematode disease as an example, this paper proposes D-SCNet, intelligent network abnormal individuals applicable UAV visible images. In...
The Stopped-Rotor (SR) UAV combines the advantages of vertical take-off and landing helicopter high-speed cruise fixed-wing aircraft. At same time, it also has a unique aerodynamic layout, which leads to great differences in control characteristics various flight modes, brings challenges dynamics modelling full-mode flight. In this paper, method SR is studied. First, based on typical profile when performing missions, using theory fuzzy mathematics, T-S model established by synthesizing each...
Based on the important role of antibiotic treatment in research interaction between Wolbachia and insect hosts, this study aimed to identify most suitable concentration for elimination P. xylostella, investigate effect bacterial community xylostella. Our results showed that Wolbachia-infected strain was plutWB1 supergroup B xylostella population collected Nepal study; 1 mg/mL rifampicin could remove infection after generation feeding toxic relatively low; among 29 samples adult our (10 WU...
<title>Abstract</title> Traffic flow prediction plays a crucial role in improving traffic management efficiency and optimizing resource allocation. However, existing models are often difficult to accurately capture complex spatial–temporal dependencies. To this end, paper proposes fusion Transformer based graph convolutional network (STFFormer-GCN) for prediction, aiming address the issues of long- short-term dynamic relationships, propagation delays, feature fusion. First, we propose...
Wolbachia bacteria (phylum Proteobacteria) are ubiquitous intracellular parasites of diverse invertebrates. In insects, coevolution has forged mutualistic associations with species, influencing reproduction, immunity, development, pathogen resistance, and overall fitness. However, the impact on other microbial associates within insect microbiome, which crucial for host fitness, remains less explored. The diamondback moth (Plutella xylostella), a major pest cruciferous vegetables worldwide,...
Abstract In situ tumor vaccines (ISTVs) hold great potential in immunotherapy, however, three major obstacles, including inadequate endogenous antigen uptake by dendritic cells (DCs), weak T-cell immune responses, and stubborn immunosuppressive microenvironment (TME) still should be fully addressed. Herein, a trifecta nanovaccine (TriNV) with TME-responsive transformable ability is developed to tri-boost antitumor immunity. First, sufficient tumor-associated antigens (TAAs) were liberated...
For the canard rotor/wing (CRW) aircraft, elliptical wing with blunt trailing edge poses challenges to control surfaces and flap design. Based on characteristics of CRW an active circulation (CC) system was introduced for aircraft lift enhancement. The designed investigated based numerical simulation. A benchmark problem used validate calibrate simulation method control. Design parameters two-dimensional (2D) determined by variant parameter analysis. curved surface optimized above design...
Taking the hard air refueling device as an object, momentum distance method is used to model it, and dynamic system which can reflect its motion characteristics obtained. The PID control law design Simulation of are carried out. simulation results show that has strong resistance vertical horizontal coupling. ground demonstration automatic docking completed on test-bed boom aerial device, further verifies feasibility meets needs engineering design.
Change detection (CD), a crucial technique for observing ground-level changes over time, is challenging research area in the remote sensing field. Deep learning methods CD have made significant progress intelligent interpretation. However, with very high-resolution (VHR) satellite imagery, technical challenges such as insufficient mining of shallow-level features, complex transmission deep-level and difficulties identifying change information features led to severe fragmentation low...