A5044045159- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Dental Implant Techniques and Outcomes
- Extracellular vesicles in disease
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Inhalation and Respiratory Drug Delivery
- Dental materials and restorations
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Bacterial biofilms and quorum sensing
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- 3D Printing in Biomedical Research
- Ultrasound and Hyperthermia Applications
- Nanoparticles: synthesis and applications
- Wound Healing and Treatments
- Luminescence and Fluorescent Materials
- Bone Tissue Engineering Materials
- Muscle Physiology and Disorders
Nanjing University
2015-2024
Nanjing Medical University
2019-2023
Nanjing Maternity and Child Health Care Hospital
2022
Providence Portland Medical Center
2017-2021
Cancer Research Center
2017-2021
Stomatology Hospital
2019
Abstract Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in biofilms because of their unique metabolic conditions biofilm infection microenvironment. Modulating microenvironment may influence state and provide alternative therapeutic routes. In this study, photodynamic therapy is used not only to eradicate methicillin-resistant Staphylococcus aureus normoxic condition, but also potentiate hypoxic microenvironment, which induces anaerobic...
Efficient treatment of chronic lung infections caused by Pseudomonas aeruginosa biofilms is a great challenge because drug tolerance and immune evasion issues. Here, we develop ultrasound-responsive catalytic microbubbles with biofilm elimination activation properties to combat infection induced P. biofilms. In these microbubbles, piperacillin Fe3O4 nanoparticles form drug-loaded shell surrounding the air core. Under ultrasound stimulation, can physically disrupt structure enhance...
The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment biofilm infections are still in great need. Herein, a novel multifunctional theranostic nanoplatform based on MnO2 nanosheets (MnO2 NSs) has been designed to achieve pH-responsive dual-mode imaging hypoxia-relief-enhanced antimicrobial photodynamic therapy (aPDT) infections. In this study, NSs were modified bovine serum albumin (BSA) polyethylene glycol (PEG)...
Dental implants are widely used in the field of oral restoration, but there still problems leading to implant failures clinical application, such as failed osseointegration, marginal bone resorption, and peri-implantitis, which restrict success rate dental patient satisfaction. Poor osseointegration bacterial infection most essential reasons resulting failure. To improve outcomes implants, many scholars devoted modifying surface especially preparing different physical chemical modifications...
Treatment of bacterial biofilms remains a great challenge in the clinic. Recently, ultrasound (US)-driven antimicrobial sonodynamic therapy (aSDT) has been considered as an emerging therapeutic strategy for treatment biofilm infections. However, hypoxic microenvironment and restricted diffusion sonosensitizers within substantially reduce efficacy aSDT. Herein, microenvironment-responsive nanoplatform was proposed to promote degradation sonosensitizer penetration, relieve microenvironment,...
Nanovaccine-based immunotherapy (NBI) has the ability to initiate dendritic cell (DC)-mediated tumor-specific immune responses and maintain long-term antitumor memory. To date, mechanism by which mechanical properties of nanoparticles alter functions DCs in NBI remains largely unclear. Here, a soft mesoporous organosilica-based nanovaccine (SMONV) is prepared elasticity-dependent effect on underlying DC-mediated studied. It found that elasticity results greater internalization SMONV DCs,...
Implant infections are difficult to cure by traditional antibiotic therapy due bacterial biofilm-induced tolerance and impaired immune responses. To efficiently treat implant infections, therapeutic agents need kill bacteria regulate the inflammatory response of cells during biofilm elimination process. Herein, multifunctional smart hollow Cu2MoS4 nanospheres (H-CMS NSs) with pH-responsive enzyme-like activities were prepared for self-adaptively eliminating biofilms regulating inflammation...
Traditional dendritic cell (DC)-mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternative strategy for evoking a robust immune response promoting DC activation. Herein, Ti
Photocatalysis offers a direct, yet robust, approach to eradicate pathogenic bacteria. However, the practical implementation of photocatalytic disinfection faces significant challenge due low-efficiency photogenerated carrier separation and transfer. Here, we present an effective improve performance by exploiting pyro-phototronic effect through synergistic combination pyroelectric properties processes. A set comprehensive studies reveals that temperature fluctuation-induced field promotes...
Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, reduce for wound treatment is presented. These findings reveal Ag/PDAs exhibit broad‐spectrum...
The Pseudomonas aeruginosa biofilm in recalcitrant chronic lung infections not only develops high antimicrobial tolerance but also induces an aberrant host inflammatory response. metabolic condition plays a vital role both the susceptibility of bacteria and response immune cells, thereby offering potential therapeutic target. Herein, we described modulation strategy by using ultrasound-responsive liposomal nanoparticles containing sonosensitizer hypoxia-activated prodrug against...
Background: Inflammatory bowel disease (IBD) is closely related to higher intracellular oxidative stress. Therefore, developing a novel method scavenge the harmful reactive oxygen species (ROS) and alleviate colon inflammation treat IBD promising strategy. Methods: CeO 2 @PDA-PEG (CeO @PP) were synthesized by modifying ceria ) nanorods with polydopamine (PDA) polyethylene glycol (PEG). The ROS scavenging ability of @PP was detected using flow cytometry confocal laser scanning microscope...
Antimicrobial phototherapy has gained recognition as a promising approach for addressing bacterial biofilms, however, its effectiveness is often impeded by the robust physical and chemical defenses of biofilms. Traditional antibacterial nanoplatforms face challenges in breaching extracellular polymeric substances barrier to efficiently deliver photosensitizers deep into Moreover, prevalent hypoxia within biofilms restricts success oxygen-reliant phototherapy. In this study, we engineered...
Abstract In situ tumor vaccines (ISTVs) hold great potential in immunotherapy, however, three major obstacles, including inadequate endogenous antigen uptake by dendritic cells (DCs), weak T‐cell immune responses, and stubborn immunosuppressive microenvironment (TME), still need to be fully addressed. Herein, a trifecta nanovaccine (TriNV) with TME‐responsive transformable ability is developed tri‐boost antitumor immunity. First, sufficient tumor‐associated antigens (TAAs) are liberated...
Background: Nanovaccines have emerged as a promising vaccination strategy, exhibiting their capacity to deliver antigens and adjuvants elicit specific immune responses. Despite this potential, optimizing the design delivery of nanovaccines remains challenge. Methods: In study, we engineered dendritic mesoporous silica-based nanocarrier enveloped in metal-phenolic network (MPN) layer containing divalent manganese ions tannic acid (MSN@MT). This was tailored for antigen loading serve...
Abstract Background We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. suppose exposure to LF-MF may modulate immune function so as inhibit tumor. here investigated whether can proliferation metastasis of melanoma influence function. Methods The effect MF on proliferation, cycle ultrastracture B16-F10 in vitro was detected by counting Kit-8 assay, flow cytometry, transmission electron microscopy. Lung mice were prepared injection...
The aim of this study was to explore the feasibility delivering tumor antigens and enhancing antigen cross-presentation dendritic cells (DCs) by aluminum hydroxide nanoparticle with polyethyleneimine (PEI) modification (LV@HPA/PEI).The LV@HPA nanoparticles were modified PEI first, then influence LV@HPA/PEI on DCs examined. distinct expression ovalbumin (OVA) protein transported into observed flow cytometry Western blot. biocompatibility LV@HPA/PEI, maturity in vitro. Tumor derived...
Abstract Host immune systems serving as crucial defense lines are vital resisting mechanisms against biofilm‐associated implant infections. Nevertheless, biofilms hinder the penetration of anti‐bacterial species, inhibit phagocytosis cells, and frustrate host inflammatory responses, ultimately resulting in weakness system for biofilm elimination. Herein, a cell‐like construct is developed through encapsulation erythrocyte membrane fragments on surface Fe 3 O 4 nanoparticle‐fabricated...