A5103113080- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Plant Molecular Biology Research
- Genomics, phytochemicals, and oxidative stress
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Oral Health Pathology and Treatment
- Glioma Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Natural Compounds in Disease Treatment
- Pharmacological Effects of Natural Compounds
- Virus-based gene therapy research
- Plant Gene Expression Analysis
- Oral and Maxillofacial Pathology
- Light effects on plants
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Protein Degradation and Inhibitors
Affiliated Hospital of Guizhou Medical University
2022-2024
Guiyang Medical University
2022-2024
Huazhong University of Science and Technology
2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Union Hospital
2024
Henan University
2022
Lymph node metastasis (LNM) is an important cause leading to recurrence and development of head neck carcinoma (HNC), with the precise mechanisms unclear. Thus, we aimed identify key genes involved in LNM further evaluate their expressions roles.A cohort HNC TCGA was analyzed. The study three phases (one screening two validation phases). First, differentially expressed regarding were screened, from which a gene identified by series data mining approaches. Then, roles validated through...
Abstract Background With the significant shift in classification, risk stratification, and standards of care for gliomas, we sought to understand how overall survival patients with these tumors is impacted by molecular features, clinical metrics, treatment received. Methods We assembled a cohort histopathologically diagnosed glioma from The Cancer Genome Atlas (TCGA), Project Genomics Evidence Neoplasia Information Exchange, Dana-Farber Institute/Brigham Women’s Hospital. This incorporated...
Nicotine is an ingredient of tobacco, and exposure to nicotine increases the risks various cancers, including oral cancer. Previous studies have focused on addictive properties nicotine, but its carcinogenic mechanism has rarely been studied. We aimed explore key genes in process through which promotes occurrence development cancer via data mining experimental verification. This study involved three parts. First, related nicotine-related were screened mining; second, expression clinical...
Due to the size and location of tumor, incomplete radiofrequency ablation (iRFA) target tumor inhibits immunity. In this study, a murine herpes simplex virus (oHSV2-mGM) armed with granulocyte-macrophage colony-stimulating factor (GM-CSF) was constructed explore its effect on innate adaptive immunity during iRFA, inhibitory programmed cell death-1 (PD1) tumor.
Abstract Background Arecoline, the main component of betel nut, induces malignant transformation oral cells through complicated unclear mechanisms. Thus, we aimed to screen key genes involved in Arecoline‐induced cancer and further verify their expressions roles. Methods This study included a data‐mining part, bioinformatics verification an experimental one. First, gene related induced by Arecoline was screened. Then, expression clinical significance head neck/oral tissues were verified, its...
Background: Celastrol, an important extract of Tripterygium wilfordii, shows strong antitumor activity in a variety tumors including nasopharyngeal carcinoma (NPC). However, little is known about its targets NPC. We aimed to screen the key gene Celastrol treatment NPC by means silico analyses (including network pharmacology and molecular docking) experimental evaluations. Methods: The main target genes related were obtained retrieving relevant biological databases, common screened....
Abstract BACKGROUND Betel nut chewing is a significant risk factor for oral cancer due to arecoline, its primary active component. Resveratrol, non‐flavonoid polyphenol, possesses anti‐cancer properties. It has been shown inhibit arecoline‐induced malignant cells in preliminary experiments but the underlying mechanism remains unclear. This research therefore aimed explore potential therapeutic targets of resveratrol treating cancer. METHODS Data mining identified common and hub Gene set...
Objectives: Nasopharyngeal carcinoma (NPC) is a highly aggressive, insidious, recurrent, and metastatic head-and-neck malignancy with poor prognosis. Bromodomain-containing 4 (BRD4) was upregulated in various tumors associated Therefore, this study aimed to investigate the biological function of BRD4 NPC molecular mechanisms expression regulation. Materials Methods: Based on big data, expression, clinical significance, possible functions cancer were explored by bioinformatics. Then, based...