A5075416147- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
- Plant Molecular Biology Research
- Antibiotic Resistance in Bacteria
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Genomics, phytochemicals, and oxidative stress
- Clostridium difficile and Clostridium perfringens research
- Acute Myeloid Leukemia Research
- Marine and coastal plant biology
- Antimicrobial Resistance in Staphylococcus
- DNA and Nucleic Acid Chemistry
- Genomics and Phylogenetic Studies
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- RNA modifications and cancer
- Plant Stress Responses and Tolerance
- DNA Repair Mechanisms
- Nigella sativa pharmacological applications
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Plant Gene Expression Analysis
- Bioactive Compounds and Antitumor Agents
- Cytomegalovirus and herpesvirus research
Haukeland University Hospital
2020-2024
University of Bergen
2020-2024
Ackerman Institute for the Family
2017-2018
Rutgers, The State University of New Jersey
2002-2018
New England Biolabs (United States)
2016
The Maria Sklodowska-Curie National Research Institute of Oncology
1970-2015
Howard Hughes Medical Institute
2011-2012
Rutgers New Jersey Medical School
2002-2007
Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy poorly understood. In this study, we investigate initial standard induction in cohort 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, find that reduction extracellular-signal-regulated kinase (ERK) 1/2 p38 mitogen-activated protein (MAPK) phosphorylation cell compartment 24 h post-chemotherapy...
A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered development new treatment strategies for people with EC.EC organoids were derived from resected patient tumor tissue expanded a chemically defined medium. Established EC orthotopically implanted into female NSG mice. Patient corresponding characterized by morphological evaluation, biomarker gene expression whole...
Superfruit guava (Psidium guajava L.) is one of the healthiest fruits due to its high antioxidant dietary fiber and vitamin content. However, growth development this plant are severely affected by salinity stress, mostly at seedling stage. MicroRNAs (miRNAs) small, noncoding, endogenous, highly conserved RNA molecules that play key regulatory roles in development, organ morphogenesis, stress response signaling. In study, applying computational approaches following stringent filtering...
MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement secondary metabolism is still limited. Murraya koenigii a popular medicinal plant, better known as curry leaves, possesses pharmaceutically active metabolites. The present study utilized high-throughput sequencing technology to investigate the miRNA profile of M. association...
Cervical cancer (CC) is a major global health problem with 570,000 new cases and 266,000 deaths annually. Prognosis poor for advanced stage disease, few effective treatments exist. Preoperative diagnostic imaging common in high-income countries MRI measured tumor size routinely guides treatment allocation of cervical patients. Recently, the role radiomics has been recognized. However, its potential to independently predict survival response requires further clarification. This retrospective...
Foeniculum vulgare Mill. commonly known as fennel, is a globally recognized aromatic medicinal plant and culinary herb with widespread popularity due to its antimicrobial, antioxidant, carminative, diuretic properties, among others. Although the phenotypic effects of salinity stress have been previously explored in molecular mechanisms underlying responses elevated this remain elusive. MicroRNAs (miRNAs) are tiny, endogenous, extensively conserved non-coding RNAs (ncRNAs) typically ranging...
The antibiotic myxopyronin (Myx) functions by inhibiting bacterial RNA polymerase (RNAP). binding site on RNAP for Myx-the "switch region SW1/SW2 subregion"-is different from the inhibitor currently used in broad-spectrum antibacterial therapy, rifampin (Rif). Here, we report frequency, spectrum, and fitness costs of Myx resistance Staphylococcus aureus. rate is 4 × 10(-8) to 7 per generation, which equal within error Rif (3 10 generation). Substitutions conferring were obtained β subunit...
Prostate cancer (PC) and colon significantly contribute to global cancer-related morbidity mortality. Thymoquinone (TQ), a naturally occurring phytochemical found in black cumin, has shown potential as an anticancer compound. This study aimed investigate the effects of TQ on expression profile key tumor suppressor onco-suppressor miRNAs PC3 prostate cells HCT-15 cells. Cell viability assays revealed that inhibited growth both cell lines dose-dependent manner, with IC50 values approximately...
Protein translation is essential for all bacteria pathogens. It has also been a major focus of structural and functional studies an important target antibiotics. Here we report our attempts to biochemically reconstitute mycobacterial protein in vitro from purified components. This system consists individually recombinant factors Mycobacterium tuberculosis (M. tuberculosis), tRNAs ribosomes smegmatis smegmatis), aminoacyl-tRNA synthetase (AARS) mixture the cell-extract M. smegmatis. We...
The pharmacological properties of plants lie in the content secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) small non-coding RNA molecules play crucial post-transcriptional regulatory roles plants, including development stress-response signaling; however, information about involvement metabolism is still limited. Cumin one most popular seeds from plant Cuminum cyminum, with extensive applications...
Protein-protein interactions (PPIs) play a vital role in most biological processes. Hence their comprehension can promote better understanding of the mechanisms underlying living systems. However, besides cost and time limitation involved detection experimentally validated PPIs, noise data is still an important issue to overcome. In last decade several silico PPI prediction methods using both structural genomic information were developed for this purpose. Here we introduce unique validation...
Comparison of the three-dimensional structure active sites MuLV and HIV-1 reverse transcriptases shows presence a lysine residue (K152) in substrate-binding region RT, while its equivalent position RT is occupied by glycine (G112). To investigate role K152 mechanism polymerase reaction catalyzed four mutant RTs, namely, K152A, K152R, K152E, K152G, were generated biochemically characterized. All muteins exhibited reduced activity on both RNA DNA template-primers with K152E being most...