A5053862074- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Clinical Nutrition and Gastroenterology
- T-cell and B-cell Immunology
- Neutropenia and Cancer Infections
- Cytokine Signaling Pathways and Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Dermatological and COVID-19 studies
Oslo University Hospital
2021-2025
Haukeland University Hospital
2015-2024
University of Bergen
2016-2023
University of Oslo
2021-2022
Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that caused activation of the classic complement pathway. Sutimlimab, humanized monoclonal antibody, selectively targets C1s protein, C1 complex serine protease responsible for activating this
Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy poorly understood. In this study, we investigate initial standard induction in cohort 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, find that reduction extracellular-signal-regulated kinase (ERK) 1/2 p38 mitogen-activated protein (MAPK) phosphorylation cell compartment 24 h post-chemotherapy...
Abstract Cold agglutinin disease (CAD) is a rare, autoimmune, classical complement pathway (CP)‐mediated hemolytic anemia. Sutimlimab selectively inhibits C1s of the C1 complex, preventing CP activation while leaving alternative and lectin pathways intact. In Part A (26 weeks) open‐label, single‐arm, Phase 3 CARDINAL study in patients with CAD recent history transfusion, sutimlimab demonstrated rapid effects on hemolysis Results B (2‐year extension) study, described herein, that sustains...
Not available.
Abstract Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1 ‐FPD), caused by monoallelic deleterious germline variants, is characterized bleeding diathesis and predisposition for hematologic malignancies, particularly myelodysplastic syndrome (MDS) acute myeloid leukemia (AML). Clinical data on FPDMM‐associated AML (FPDMM‐AML) are limited, complicating evidence‐based clinical decision‐making. Here, we present retrospective genetic of the largest cohort FPDMM...
Several pretransplant factors, including CRP (C-reactive protein) levels, reflect the risk of complications after allogeneic stem cell transplantation. IL-6 induces increase, and we therefore investigated effects IL-6, soluble receptors, family cytokines serum levels on outcome for 100 consecutive allotransplant recipients. All patients had related donors, none active infections 99 were in complete remission before conditioning. The incidence acute graft versus host disease (aGVHD) requiring...
The Bacillus Calmette-Guérin (BCG) vaccine is administered at birth in tuberculosis (TB) endemic countries. BCG vaccination also associated with protective non-specific effects against non-tuberculous infections. This seems least part mediated through induction of innate immune memory myeloid cells, a process termed trained immunity. β-glucan, component the fungal cell wall from Candida albicans, induces immunity phenotype human monocytes hyper-responsiveness unrelated pathogens. We aimed to...
Abstract Purpose An improved understanding of RCC immunology should shed further light on tumor biology. Our objective was to study what extent serum levels the IL-6 family cytokines at diagnosis were relevant survival. Methods A total 118 consecutively patients with RCC, in which surgically removed Haukeland University Hospital during period from 2007 2010, included. The followed-up for 10 years. morning before surgery blood sampled and frozen, IL-6, IL-27, IL-31, OSM, CNTF, IL-6Rα gp130...
The understanding of coronavirus disease 2019 (COVID-19) is rapidly evolving. Although it primarily a respiratory illness, other manifestations, such as Guillain-Barré syndrome, immune thrombocytopenia, and immune-mediated thrombotic thrombocytopenic purpura, have been described. We present case patient with hemophagocytic lymphohistiocytosis secondary to COVID-19 treated tocilizumab marked biochemical improvement.In this report we Caucasian who developed elevation inflammatory parameters...
Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target rapamycin (PI3K-Akt-mTOR) pathway present AML cells, and this integrates signaling from several upstream receptors/mediators. We suggest that reflects biologically important clonal heterogeneity. investigated constitutive PI3K-Akt-mTOR primary human cells derived 114 patients,...
Acute myeloid leukaemia (AML) is a heterogeneous malignancy; we studied how the constitutive cytokine release by AML cells varies among patients.We investigated of 28 mediators during in vitro culture for 79 consecutive patients.Constitutive profiles differed patients, and hierarchical clustering identified three subsets with high, intermediate low release, respectively. The high-release subset showed high levels most mediators, usually monocytic differentiation as well altered mRNA...
Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During last decade, interest micro RNAs (miRNAs) in pathophysiological process cGVHD has increased. The objectives this study were to investigate a wide range serum miRNAs allografted patients and identify associations between cGVHD. included 79 allotransplanted adults, where samples obtained 1 year after allo-HSCT, miRNA profiling analysis...