A5080010131- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Uterine Myomas and Treatments
- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- Face Recognition and Perception
- Cervical Cancer and HPV Research
- Cancer Risks and Factors
- Bone and Dental Protein Studies
- Prostate Cancer Treatment and Research
- Protease and Inhibitor Mechanisms
- GDF15 and Related Biomarkers
University of Bergen
2017-2025
Haukeland University Hospital
2017-2025
University of East Anglia
2019
Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers, potential HER2 as a therapeutic target other cancers has been less studied, including endometrial cancer. We investigated expression levels (ERBB2) large cohort cancer lesions, also complex atypical hyperplasia metastatic lesions. 67 precursor 790 primary 383 lesions were for relation to clinicopathologic features outcome. Protein assessed by...
PD-L1 and PD-1 are predictive markers for immunotherapy increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression tumors, also stratified by MSI. As is foremost metastatic disease, was assessed corresponding lesions.PD-L1 a prospective, population based cancer cohort 700 patients with lesions from 68 74 respectively. Fresh tissue used gene analysis.In expressed 59% 63%, respectively, but no impact on...
A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered development new treatment strategies for people with EC.EC organoids were derived from resected patient tumor tissue expanded a chemically defined medium. Established EC orthotopically implanted into female NSG mice. Patient corresponding characterized by morphological evaluation, biomarker gene expression whole...
The presence of cancer stem cells is linked to aggressive disease and higher risk recurrence, multiple markers have been proposed detect cells. However, a detailed evaluation the expression patterns prognostic value relevant for endometrial lacking. As organoid models are suggested be enriched in cells, such may prove valuable define tissue-specific To address this, imaging mass cytometry multiplex single-cell analyses were performed on an patient series including both tumor biopsies...
Abstract Prognostication is critical for accurate diagnosis and tailored treatment in endometrial cancer (EC). We employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-, transcriptomic- molecular biomarkers ( 550 aiming identify aggressive tumor features a study including 866 EC patients. Whole-volume radiomic profiling from manually (radiologists) segmented tumors 138 yielded clusters identifying patients high-risk histological...
Cervical cancer (CC) is a major global health problem with 570,000 new cases and 266,000 deaths annually. Prognosis poor for advanced stage disease, few effective treatments exist. Preoperative diagnostic imaging common in high-income countries MRI measured tumor size routinely guides treatment allocation of cervical patients. Recently, the role radiomics has been recognized. However, its potential to independently predict survival response requires further clarification. This retrospective...
The endometrial cancer mismatch repair (MMR) deficient subgroup is defined by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative and operative samples investigate the prognostic impact differential protein expression levels.Tumour lesions from 1058 patients were immunohistochemically stained for was evaluated as intact to determine status, staining index evaluate potential expression. Gene data a local (n = 235) TCGA 524) cohorts used validation.We identified...
It has repeatedly been argued that individual differences in personality influence emotion processing, but findings from both the facial and vocal recognition literature are contradictive, suggesting a lack of reliability across studies. To explore this relationship further more systematic manner using Big Five Inventory, we designed two studies employing different research paradigms. Study 1 explored between traits accuracy while 2 examined how relate to speed. The combined results did not...
Imaging of clinically relevant preclinical animal models is critical to the development personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting heterogeneous molecular subtypes are considered most models, their use in limited by lack appropriate imaging modalities. Here, we describe a near-infrared fluorescently labeled monoclonal antibody targeting epithelial cell adhesion molecule (EpCAM) as an vivo modality...
ObjectiveMain controversies in endometrial cancer treatment include the role of lymphadenectomy and optimal adjuvant treatment. We assessed clinical outcome a population-based cohort relation to changes management over two decades.MethodsAll consenting patients receiving primary at Haukeland University Hospital from 2001 2019 were included (n = 1308). Clinicopathological variables evaluated for year-to-year changes. Clinical before after discontinuing radiotherapy individualizing extent was...
This study reanalyzes epidermal growth factor receptor 2 (ERBB2) data from a previous to characterize patient subgroups with ERBB2-low tumors.
Abstract Background Precise preoperative risk classification of endometrial cancer is crucial for treatment decisions. Existing clinical markers often fail to accurately predict lymph node metastasis and recurrence risk. Loss vimentin expression has emerged as a potential marker predicting in low-risk patients. We assessed whether biopsies predicts poor prognosis large multicentre cohort. Methods Vimentin was evaluated using immunohistochemistry 1483 patients diagnosed with across 14...
In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed develop models that integrate protein data information identify requiring more aggressive surgery, including lymphadenectomy.Protein expression profiles were generated for 399 using reverse-phase array. Three generalised linear built on proteins (model 1), also magnetic resonance imaging included 2),...
Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up in detecting recurrent disease endometrial cancer (EC) patients, however the preclinical use of these methods is currently limited. We demonstrate feasibility utility MRI dynamic 18F-fluorodeoxyglucose (FDG)-PET for monitoring tumor progression assessing chemotherapy response orthotopic organoid-based patient-derived xenograft...
Objective Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was explore the applicability plasma growth differentiation factor 15 (GDF-15) as marker for recurrent disease, well poor prognosis lymph node metastases. Methods EDTA-blood samples were obtained 235 cancer before primary surgery. For 36 these patients, matching blood collected time recurrence. Blood...
<h3>Introduction/Background</h3> Radiomics can capture microscale information in medical images beyond what is visible to the naked human eye. Using a clinically relevant mouse model for endometrial cancer, objective of this study was develop and validate radiomic signature (RS) predicting response standard chemotherapy. <h3>Methodology</h3> Mice orthotopically implanted with patient-derived grade 3 endometrioid cancer organoid (O-PDX) were allocated chemotherapy (combined...
Radiomics can capture microscale information in medical images beyond what is visible to the naked human eye. Using a clinically relevant mouse model for endometrial cancer, objective of this study was develop and validate radiomic signature (
If detected early, most cervical cancers associate with good prognosis. However, survival rates drop significantly for late stage or recurrent disease, and treatment options are limited. Antibody drug conjugates (ADCs) represents a new group of cancer drugs providing promising response across multiple types. only the ADC tisotumab vedotin (TV) is approved by Food Drug Administration (FDA) use in cancer. The aim this study was to assess expression target proteins TROP2, Tissue factor (TF)...
Precise preoperative risk classification of endometrial cancer is crucial to guide selection treatment. Still, 15-20% tumors classified as low-risk recur. Loss expression vimentin was recently identified a marker recurrence in patients with low stage disease. We aimed investigate if biopsies could predict poor prognosis and lymph-node metastasis large, prospectively collected multicentre cohort. Preoperative were from 1483 diagnosed treated for 10 hospitals Norway, Sweden, Belgium Polen....
Pre-operative histologic subtype and deep myometrial infiltration at magnetic resonance imaging are strong predictors of high-risk disease in endometrial cancer (EC). Whether molecular combination with hormone receptor status can refine conventional risk stratification is uncertain. A prospectively collected EC cohort including 446 patients was molecularly subtyped using surrogate markers the WHO-endorsed classification algorithm. Median follow-up 6.4 years. Estrogen- progesterone (ER PR)...
Although early-detected cervical cancer is associated with good survival, the prognosis for late-stage disease poor and treatment options are sparse. Mismatch repair deficiency (MMR-D) has surfaced as a predictor of response to immune checkpoint inhibitor(s) in several types, but its value remains unclear. This study aimed define prevalence MMR-D assess prognostic MMR protein expression. Expression proteins MLH-1, PMS-2, MSH-2, MSH-6 was investigated by immunohistochemical staining...