Diamantis I. Tsilimigras

ORCID: 0000-0002-3676-9263
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About
Contact & Profiles
Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Gallbladder and Bile Duct Disorders
  • Neuroendocrine Tumor Research Advances
  • Gastric Cancer Management and Outcomes
  • Lung Cancer Research Studies
  • Cardiac, Anesthesia and Surgical Outcomes
  • Liver Disease Diagnosis and Treatment
  • Colorectal Cancer Screening and Detection
  • Viral-associated cancers and disorders
  • Cancer, Lipids, and Metabolism
  • Neuroblastoma Research and Treatments
  • Palliative Care and End-of-Life Issues
  • Healthcare Policy and Management
  • Esophageal Cancer Research and Treatment
  • Colorectal Cancer Surgical Treatments
  • Colorectal Cancer Treatments and Studies
  • Inflammatory Biomarkers in Disease Prognosis
  • Gastrointestinal Tumor Research and Treatment
  • Enhanced Recovery After Surgery
  • Economic and Financial Impacts of Cancer
  • Metastasis and carcinoma case studies
  • Sarcoma Diagnosis and Treatment
  • Pediatric Hepatobiliary Diseases and Treatments

The Ohio State University Wexner Medical Center
2018-2025

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2018-2024

National and Kapodistrian University of Athens
2017-2024

The Ohio State University
2018-2024

Yahoo (United Kingdom)
2024

Centers for Medicare and Medicaid Services
2024

Hippocration General Hospital
2024

Yokohama City University
2022

Massanutten Regional Library
2020

American Surgical Association
2020

Although surgery offers the best chance of a potential cure for patients with localized, resectable intrahepatic cholangiocarcinoma (ICC), prognosis remains dismal largely because high incidence recurrence.To predict very early recurrence (VER) (ie, within 6 months after surgery) following resection ICC in pre- and postoperative setting.Patients who underwent curative-intent between May 1990 July 2016 were identified from an international multi-institutional database. The study was conducted...

10.1001/jamasurg.2020.1973 article EN JAMA Surgery 2020-07-08

Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim the present study was to investigate control and consequences CSE activity in endothelial cells under physiological proatherogenic conditions.Endothelial cell knockout mice were generated, lung studied vitro (gene expression, protein sulfhydration, monocyte adhesion). Mice crossed onto apolipoprotein E-deficient background, atherogenesis (partial carotid artery...

10.1161/circulationaha.118.034757 article EN Circulation 2018-07-03

Abstract Background Although the Barcelona Clinic Liver Cancer (BCLC) staging system has been largely adopted in clinical practice, recent studies have emphasized need for further refinement and subclassification of this system. Methods Patients who underwent hepatectomy with curative intent BCLC-0, -A or -B hepatocellular carcinoma (HCC) between 2000 2017 were identified using a multi-institutional database. The tumour burden score (TBS) was calculated, overall survival (OS) examined...

10.1002/bjs.11464 article EN British journal of surgery 2020-02-14

In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase (CSE), generates hydrogen sulfide-related sulfane sulfur compounds (H2Sn), that exert their biological actions via S-sulfhydration of target proteins. This study set out to map "S-sulfhydrome" (ie, spectrum proteins targeted H2Sn) in human cells.Liquid chromatography with tandem mass spectrometry was used identify S-sulfhydrated cysteines cell and β3 integrin intraprotein disulfide bond rearrangement. Functional...

10.1161/circulationaha.120.051877 article EN Circulation 2020-12-14

Objective: The objective of the current study was to define surgical outcomes after resection multinodular hepatocellular carcinoma (HCC) beyond Milan criteria, and develop a prediction tool identify which patients likely benefit most from resection. Background: Liver for HCC, especially remains controversial. Rigorous selection best candidates is essential achieve optimal liver advanced tumors. Methods: Patients who underwent HCC between 2000 2017 were identified an international...

10.1097/sla.0000000000004346 article EN Annals of Surgery 2020-09-10
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