A5061370456- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Heme Oxygenase-1 and Carbon Monoxide
- High Altitude and Hypoxia
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Hormonal Regulation and Hypertension
- Infectious Encephalopathies and Encephalitis
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Microbial infections and disease research
- Thermal Regulation in Medicine
- Influenza Virus Research Studies
- Hematological disorders and diagnostics
- Infective Endocarditis Diagnosis and Management
- Diabetic Foot Ulcer Assessment and Management
- Dermatological and COVID-19 studies
- Eicosanoids and Hypertension Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory and Cough-Related Research
Children's Hospital of Zhejiang University
2019-2024
Zhejiang University
2020
Dalian Medical University
2012
First Affiliated Hospital of Dalian Medical University
2012
Despite the expanded immunization programs, "re-emergence of pertussis" has become a global concern in recent years. At present, prevalence pertussis China is seriously underestimated, and role close contact on disease spreading children remains unclear. Our study aimed to investigate pertussis's epidemiological clinical characteristics their contacts households, as well antimicrobial resistance Bordetella (B. pertussis) Zhejiang Province, China. We have collected retrospective prospective...
The purpose of the current study is to investigate bactericidal effect macrolides and β-lactams on Bordetella pertussis (B. pertussis) in nasopharynx provide guidance for treating macrolides-resistant B. infections.Patients with whooping cough was diagnosed by culture swabs between January 2016 December 2018. identified using specific antisera against parapertussis. Drug susceptibility test carried out E-test method. clearance at 7 14 days into posttreatment macrolides, compared.A total 125...
Abstract Background HAdV is one of the common pathogens in hospitalized children with acute respiratory infections (ARIs). We aim to describe clinical and laboratory features, epidemiological characteristics, species and/or types inpatients infections. Methods Respiratory samples were gathered from diagnosed ARIs Children’s Hospital, Zhejiang University School Medicine, detected by using Direct Immunofluorescence Assay 2018 2019. PCR amplification sequencing hypervariable zone hexon gene...
Abstract Objective This investigation aimed to delineate the clinical manifestations associated with high‐altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) in pediatric populations find risk factors of HAPE. Methods We conducted a retrospective analysis data from children under 18 years diagnosed HAPE AMS at an average altitude 3000 m. The between these two groups were compared. Results study encompassed 74 patients, 27 47 presentations included classic (55.3%), reentry...
Abstract Background Different from the diagnosis of bacterial infections, Mycoplasma pneumoniae pneumonia (MPP) is still lacking convenient non‐specific laboratory parameters. Method A total 125 children with MPP were included in group and 89 Mycoplasma‐ negative control group, sera collected at both acute recovery stages two groups. Results The sialic acid C3 significantly higher than those stage. On other hand, stage group. However, demonstrated IgG exhibited no significant change between...
Many clinical conditions can cause fever of unknown origin (FUO) in children, but the etiological diagnosis remains challenging despite variety inspection methods available at present. This study aims to investigate effectiveness droplet digital polymerase chain reaction (ddPCR) identifying pathogens children with FUO as a novel application. A 7-month-old boy failed obtain etiology evidence for his disease through various tests. After collecting peripheral blood ddPCR analysis,
From December 2022 to January 2023, seven children aged ≤14 years and residing in an area at 2999 m without altitude change the past month developed severe cough, dyspnea, cyanosis, pulmonary lesions within 2-3 days after SARS-CoV-2 infection. They were diagnosed have high-altitude resident edema. completely recovered following 4-7 of treatment with oxygen inhalation, vasodilation, diuretics, glucocorticoids.
Objective: To observed whether (pro)renin could activate ERK and p38 MAPK singaling pathway increase the expression of VCAM-1 reduce activity SOD independent AngII in HUVECs. Methods: Cells were treated with after blockage AT1 AT2 olmsartan PD123319. (P)RR HUVEC was by RNA interference. The protein level investigated Western blot ELISA method. Results: (Pro)renin up-regulated phosphorylated MAPKs VCAM-1. And decreased (pro)renin. activation inhibited (P)RR-RNA siRNA inhibite SOD....
Objective: To observed whether prorenin could activate PI3K, AKT, NFκB and IL-6 in HUVECs through (P)RR independent of angiotensinII (AngII). study HRP exists effect on blocking. Methods: Cells were treated with after the blockage AT1 AT2 olmsartan PD123319. HUVEC was by RNA interference different concentrations. PI3K/AKT blocked wortmannin. The protein level investigated Western blot ELISA method. Results: Prorenin up-regulated expression p-AKT, NFκB-P65, IL-6. activation NFκB-P65 inhibited...
Abstract Background : HAdV is one of the common pathogens in hospitalized children with respiratory infection (RI). we aim to describe epidemiological characteristics, clinical features, and genotype inpatients positive RI. Methods Respiratory samples were gathered from diagnosed RI Children’s Hospital, Zhejiang University School Medicine detected by using Direct Immunofluorescence Assay (DFA) 2018 2019. PCR amplification sequencing hypervariable zone hexon gene used for genotyping. The...