Mihoko Saito-Adachi
A5010401320- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Evolution and Genetic Dynamics
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Pancreatic and Hepatic Oncology Research
- Nutrition, Genetics, and Disease
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- RNA Research and Splicing
- Telomeres, Telomerase, and Senescence
- Cancer, Hypoxia, and Metabolism
National Cancer Research Institute
2024
Weatherford College
2024
Osaka University
2024
Tokyo Institute of Technology
2024
National Cancer Centre Japan
2018-2023
The University of Tokyo
2014-2016
Abstract The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing, transcriptome DNA methylation assays, and/or ATAC-seq and found GIS-NECs to be genetically distinct from tumors (GIS-NET) in same location. Clear genomic differences were also evident between pancreatic NECs (Panc-NEC) nonpancreatic (Nonpanc-NEC). Panc-NECs could classified into two subgroups (i.e., “ductal-type”...
Abstract The accumulations of different types genetic alterations such as nucleotide substitutions, structural rearrangements and viral genome integrations epigenetic contribute to carcinogenesis. Here, we report correlation between the occurrence features aberrations by whole-genome bisulfite, shotgun, long-read, virus capture sequencing 373 liver cancers. Somatic substitutions rearrangement breakpoints are enriched in tumor-specific hypo-methylated regions with inactive chromatin marks...
Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic options for this type of cancer. Here, we present comprehensive characterization the genetic alterations in TNBC performed by high coverage whole genome sequencing together with transcriptome and exome sequencing. Silencing BRCA1 gene impaired homologous...
Abstract PAX6 is the key transcription factor involved in eye development humans, but differential functions of two isoforms, isoform-a and isoform-b, are largely unknown. To reveal their function corneal epithelium, along with reprogramming factors, were transduced into human non-ocular epithelial cells. Herein, we show that isoforms differentially cooperatively regulate expression genes specific to structure particularly keratin 3 (KRT3) 12 (KRT12). induced KRT3 by targeting its upstream...
The transcription factor E74-like 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role ELF3 bile duct cells by identifying several previously unknown direct target genes that appear to be implicated carcinogenesis. directly repressed ZEB2, key regulator epithelial-mesenchymal transition, and upregulated expression CGN, an integral element lumen formation. Loss led decreased cell-cell junctions enhanced cell...
Renal cell carcinoma (RCC) comprises several histological types characterised by different genomic and epigenomic aberrations; however, the molecular pathogenesis of each type still requires further exploration. We perform whole-genome sequencing 128 Japanese RCC cases histology to elucidate significant somatic alterations mutagenesis processes. also transcriptomic identify distinguishing features, including assay for transposase-accessible chromatin (ATAC-seq) methyl sequencing. Genomic...
Abstract Structural variants (SVs) are responsible for driver events in gastric cancer (GC); however, their patterns and processes remain poorly understood. Here, we examine 170 GC whole genomes to unravel the oncogenic structural aberration landscape identify six rearrangement signatures (RSs). Non-random combinations of RSs elucidate distinctive subtypes comprising one or a few dominant RS that associated with specific ( BRCA1/2 defects, mismatch repair deficiency, TP53 mutation)...
Extrinsic and intrinsic regulators are responsible for the tight control of hematopoietic stem cells (HSCs), which differentiate into all blood cell lineages. To understand fundamental basis HSC biology, we focused on differentially expressed genes (DEGs) in long-term short-term HSCs, closely related terms development but substantially differ their capacity. analyze transcriptional regulation DEGs identified novel transcriptome profiles obtained by our RNA-seq analysis, developed a...
<title>Abstract</title> The recent rapid increase in colorectal cancer (CRC) cases, particularly among young patients, poses a significant public health concern Japan and other countries. association between the gut microbiota CRC has been well established. Here, we present detailed analysis of this by combining whole-genome sequencing (WGS) whole-transcriptome data from tissues with metagenomic (WGMS) fecal samples. utilization explanatory artificial intelligence enabled classification...
<p>Supplemental experimental procedures, Figure S1-S16, Table S5</p>
<p>Supplemental experimental procedures, Figure S1-S16, Table S5</p>
<div>Abstract<p>The transcription factor E74-like 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role ELF3 bile duct cells by identifying several previously unknown direct target genes that appear to be implicated carcinogenesis. directly repressed ZEB2, key regulator epithelial–mesenchymal transition, and upregulated expression CGN, an integral element lumen formation. Loss led decreased cell–cell...
<div>Abstract<p>The transcription factor E74-like 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role ELF3 bile duct cells by identifying several previously unknown direct target genes that appear to be implicated carcinogenesis. directly repressed ZEB2, key regulator epithelial–mesenchymal transition, and upregulated expression CGN, an integral element lumen formation. Loss led decreased cell–cell...
<div>Abstract<p>The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing, transcriptome DNA methylation assays, and/or ATAC-seq and found GIS-NECs to be genetically distinct from tumors (GIS-NET) in same location. Clear genomic differences were also evident between pancreatic NECs (Panc-NEC) nonpancreatic (Nonpanc-NEC). Panc-NECs could classified into two subgroups...
<div>Abstract<p>The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing, transcriptome DNA methylation assays, and/or ATAC-seq and found GIS-NECs to be genetically distinct from tumors (GIS-NET) in same location. Clear genomic differences were also evident between pancreatic NECs (Panc-NEC) nonpancreatic (Nonpanc-NEC). Panc-NECs could classified into two subgroups...
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System
Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas the Gastrointestinal System