A5104103562- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Radiology practices and education
- Advanced Radiotherapy Techniques
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Cardiac Imaging and Diagnostics
- Effects of Radiation Exposure
- RNA Research and Splicing
- Ultrasound in Clinical Applications
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Central Venous Catheters and Hemodialysis
National Cancer Centre Japan
2018-2024
Siemens Healthcare (Germany)
2023
Bayer (Germany)
2023
Research Institute for Brain and Blood Vessels Akita
2015-2022
Tohoku University
2011-2021
Kubota (Japan)
2018-2021
Akita University
2020
Tokyo Denki University
2020
Oita Medical Center
2009-2014
Percutaneous coronary intervention (PCI) offers great benefit that could improve a patient's quality of life. However, numerous case reports patient radiation injury resulting from PCI are being published, these likely represent small fraction the actual cases.To demonstrate appropriate duration follow-up after to identify effects.We evaluated 400 consecutive PCIs. The dose (dose-area product, cumulative dose, maximum skin dose), number cine runs, and fluoroscopic time were recorded for all...
Neurovascular interventional radiology (neuro-IR) procedures tend to require an extended fluoroscopic exposure time and repeated digital subtraction angiography. To evaluate the actual measurement of eye lens dose using a direct dosemeter in neuro-IR physicians is important. Direct dosimetry DOSIRIS™ (IRSN, France) [3 mm equivalent, Hp(3)] was performed on 86 cases. Additionally, neck personal (glass badge) [0.07 Hp(0.07)] worn outside protective apron left neck. The average doses per case...
Interventional radiology (IR) utilizing X-rays can lead to occupational radiation exposure, posing health risks for medical personnel in the field. We previously conducted a survey on exposure of IR nurses three designated emergency hospitals Japan. Our findings indicated that hospital with 214 beds showed higher lens-equivalent dose than 678 and 1182 because distance between X-ray irradiation field nurse's position was shorter those beds. Based these observations, we hypothesized number...
Radiation protection/evaluation during interventional radiology (IVR) poses a very important problem. Although IVR physicians should wear protective aprons, the physician may not tolerate wearing one for long procedures because aprons are generally heavy. In fact, orthopedic problems increasingly reported in due to strain of heavy IVR. recent years, non-Pb (lighter weight, composite materials) have been developed. more expensive than Pb former weigh less. However, whether performance is...
In a previous study, we reported on novel (prototype) real-time patient dosimeter with non-toxic phosphor sensors. this developed new types of sensors that were smaller than in the prototype, and clarified clinical feasibility our newly proposed dosimeter. Patient dose measurements obtained compared using calibrated radiophotoluminescence glass reference (RPLD). The dosimeters set at almost same positions as We found excellent correlations between RPLD those (r2 = 0.967). However, type was...
Interventional radiology (IR) procedures tend to be complex, which delivers high radiation exposure patient. In the present study, we measured dose [Hp(3)] in eye using a direct dosemeter placed next physician's during procedures. Physicians wore just lateral eyes and an additional outside protective eyeglasses close their eyes. Additionally, neck glass badge was worn at neck. Although found positive correlation between left [Hp(0.07)] lens [Hp(3)], value of R2 regression equation were 0.62...
ALARAas low as reasonably achievable CTDI computed tomography dose index DLP dose-length product DRL diagnostic reference level FPD flat panel detector ICRP International Commission on Radiological Protection IVR interventional radiology KAP kerma-area PSD peak skin
The purpose of this research was to measure accurate patient entrance skin dose and maximum absorbed (MSD) prevent radiation injuries in percutaneous coronary interventions (PCIs). We directly measured the MSD on 50 PCIs by using multiple radiophotoluminescence glass dosimeters a modified dosimetry gown. Also, we analysed correlation between indirect measurement parameters, such as fluoroscopic time (FT), dose-area product (DAP) cumulative air kerma (C-AK). There were very strong...
Abstract To propose reference values for air-kerma at the point (Ka,r), area product (PKA), fluoroscopy time (FT) and number of cine images (CI) four age groups in Japan, a nationwide questionnaire was posted to 132 pediatric catheterisation certified facility using conventional post system, which 43 facilities responded. For diagnostic cardiac angiography, were as follows: Ka,r: 86, 102, 165 264 mGy; PKA: 9.3, 9.5, 16 34 Gy.cm2; FT: 33, 29, 26 30 min CI: 1904, 1966, 2405 1871 images....
Angiographic equipment has tended toward using flat-panel detector (FPD). However, the radiation dose varies depending on size of field view (FOV) in FPD. Although we were 7 inch FOV cardiac procedures, examined a way to reduce patients' by 8 utilizing digital zoom processing. We measured absorbed rates at an interventional reference point (IRP) with 20 cm acrylic board compare processing FOV. Additionally visually evaluated these phantom images. Result comparison IRP, was reduced more than...
It is very important to manage the radiation dose of cardiovascular interventional (CVI) procedures. Overseas, diagnostic reference levels for cardiac procedures were established with air kerma at patient entrance point (Ka,r) and kerma-area product (PKA). Although Japan DRLs 2015 was by Network Research Information on Medical Exposure (J-RIME), DRL CVIs fluoroscopic rates 20 mGy/min cm thickness polymethyl methacrylate (PMMA) phantom. In present our study, we performed a questionnaire...
Deterministic effects have been reported in cardiac interventional procedures. To prevent radiation skin injuries percutaneous coronary intervention (PCI), it is necessary to measure accurate patient entrance dose (ESD) and maximum absorbed (MSD). We measured the MSD on 62 patients four facilities by using Chest-RADIRECⓇ system. The correlation between fluoroscopic time, area product (DAP), cumulative air kerma (AK) showed good results, with AK being strongest. regression lines as an outcome...
Abstract Immune reactions in the tumor micro-environment are one of cancer hallmarks and emerging immune therapies have been proven effective many types cancer. To investigate genome-immune interactions role immuno-editing or escape mechanisms development, we analyzed 2,834 whole genomes RNA-seq datasets across 31 distinct from PanCancer Analysis Whole Genomes (PCAWG) project with respect to key immuno-genomic aspects. We show that selective copy number changes immune-related genes could...
Determining a novel etiology and mechanism of human cancer requires extraction characteristic mutational signatures derived from chemical substances. This study explored the N-nitroso bile acid conjugates using Salmonella strains. Exposing S. typhimurium TA1535 to N-nitroso-glycine/taurine induced predominance C:G T:A transitions. Two signatures, B1 B2, were extracted. Signature is associated with N-nitroso-glycine conjugates, while B2 linked N-nitroso-taurine conjugates. revealed strong...
The International Commission on Radiological Protection recommended that interventional radiologies (IRs) have high radiation doses and staff may also be exposed to doses. In the present study, we measured exposure dose [3 mm equivalent, Hp (3) ] in eye using an appropriate dosimeter placed next physician' s during neurovascular intervention procedure (Neuro-IR) cardiac electrophysiology (EP-IR).Physicians wore a direct dosemeter just lateral left additional outside protective glasses close...
<div>Abstract<p>Cancer chemoresistance is often attributed to the presence of cancer stem cell (CSC)-like cells, but whether they are homogeneously chemoresistant remains unclear. We previously showed that in colon tumors, a subpopulation <i>LGR5<sup>+</sup></i> CSC-like cells driven by TCF1 (TCF7), Wnt-responsive transcription factor, were responsible for tumorigenicity. Here we demonstrate tumorigenic mouse exists slow-cycling state and identify unique...
<div>Abstract<p>Cancer chemoresistance is often attributed to the presence of cancer stem cell (CSC)-like cells, but whether they are homogeneously chemoresistant remains unclear. We previously showed that in colon tumors, a subpopulation <i>LGR5<sup>+</sup></i> CSC-like cells driven by TCF1 (TCF7), Wnt-responsive transcription factor, were responsible for tumorigenicity. Here we demonstrate tumorigenic mouse exists slow-cycling state and identify unique...
Abstract To propose Japanese national DRLs for air-kerma at the reference point (K a,r ), area product (P KA fluoroscopy time (FT), and number of cine images (CI) four age groups. We posted a nationwide questionnaire to 132 facilities. Questions focused on identifying procedure, age, weight, height, K , P FT, CI during diagnostic therapeutic pediatric cardiac catheterization. For angiography, 75th percentile values were as follows; : 103, 127, 194, 351 mGy; 7.0, 12.3, 14.3, 47.2 Gy.cm 2 ;...
To discuss the circumstances of patient skin injury in cardiac interventional radiology (IVR). demonstrate importance evaluating radiation dose IVR. show need for appropriate follow-up after IVR to identify effects. highlight incidence injuries during IVRs.Evaluation 400 consecutive percutaneous coronary interventions (PCIs). The dose, number cine runs, and fluoroscopic time were recorded all patients. on patients' backs was reviewed periodically PCI injury. relationships between effects...
In recent years, dose justification and optimization have been attempted in percutaneous coronary intervention (PCI); however, deterministic effects reported. To prevent radiation skin injuries PCI, it is necessary to measure the patient entrance (ESD), but an accurate measurement method has not yet established. this study, we developed a dosimetry gown that can ESD during PCI using multiple radiophotoluminescence dosimeters (RPLDs). The RPLDs were placed into 84 pockets sewn gown. Patients...
To propose typical values for the arrhythmia region between pulmonary vein isolation (PVI) and nonpulmonary (non-PVI) in Japan. A nationwide questionnaire was posted to 343 facilities, which 125 facilities (36.4%) responded. Results is median PVI non-PVI were terms of Ka,r (317 196 mGy), PKA (40.8 26.3 Gy.cm2), FT (43.0 27.3 min), CI (326 102 images). When comparing procedures, there significant differences Ka, r, PKA, FT, (p < 0.05). In other words, by classifying into two types, non-PVI,...