A5032510593- Glioma Diagnosis and Treatment
- Hydrogels: synthesis, properties, applications
- ATP Synthase and ATPases Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Hypoxia, and Metabolism
- biodegradable polymer synthesis and properties
- Meningioma and schwannoma management
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Testicular diseases and treatments
- Intracranial Aneurysms: Treatment and Complications
- Advanced Drug Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Neuroblastoma Research and Treatments
- Cytomegalovirus and herpesvirus research
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Head and Neck Surgical Oncology
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Herpesvirus Infections and Treatments
- Cardiac tumors and thrombi
- Brain Metastases and Treatment
- Neuroscience of respiration and sleep
Kansai University
2013-2024
St. Marianna University School of Medicine
2011-2024
Research Institute for Brain and Blood Vessels Akita
1998-2024
University of Fukui
2020-2023
Osaka Hospital
2004-2023
Fukui Red Cross Hospital
2022
Japan Community Healthcare Organization
2015-2021
University of California, San Francisco
2013-2020
Gifu Prefectural General Medical Center
2019
Waseda University
2019
Abstract Purpose: Cidofovir (CDV) is an U.S. Food and Drug Administration (FDA)-approved nucleoside antiviral agent used to treat severe human cytomegalovirus (HCMV) infection. Until now, no clear therapeutic effects of CDV have been reported outside the setting viral infection, including a potential role for as antineoplastic treatment brain tumors. Experimental Design: We investigated cytotoxicity against glioblastoma cells, U87MG primary SF7796, both in vitro vivo, using intracranial...
Neurovascular interventional radiology (neuro-IR) procedures tend to require an extended fluoroscopic exposure time and repeated digital subtraction angiography. To evaluate the actual measurement of eye lens dose using a direct dosemeter in neuro-IR physicians is important. Direct dosimetry DOSIRIS™ (IRSN, France) [3 mm equivalent, Hp(3)] was performed on 86 cases. Additionally, neck personal (glass badge) [0.07 Hp(0.07)] worn outside protective apron left neck. The average doses per case...
<b><i>Objective:</i></b> To assess the safety and efficacy of hyperbaric oxygen (HBO) for treating radiation cystitis a long-term follow-up study was done in patients with prostate cancer, second most common malignancy Japan. <b><i>Patients Methods:</i></b> A total 38 at an age 68 ± 8 years following irradiation cancer were treated HBO 2 absolute atmospheric pressures 90 min daily. The average number treatment sessions each patient 62 12....
Biodegradable injectable polymer (IP) systems exhibiting temperature-responsive sol-to-gel transitions between room temperature and body have the potential for use in biomedical applications. However, gelation of such IP is a reversible process through physical cross-linking, hydrogels thus formed are likely to revert sol state under highly wet conditions after injection. In this study, biodegradable system irreversible transition by covalent bond formation was developed simple mixing...
OBJECTIVE Plaque composition, but not degree of stenosis, may play a key role in the development recurrent ischemic events patients with symptomatic mild (< 50%) carotid artery stenosis. This multicenter prospective cohort study was aimed to determine their clinical and radiological features evaluate benefits endarterectomy (CEA) for them. METHODS included 124 cerebrovascular or retinal ipsilateral Best medical therapy (BMT) administered all participants. CEA stenting implemented at each...
Abstract Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disease mainly affecting apocrine gland‐rich areas of the body with painful nodules, persisted abscess, sinus tracts, and scarring. The etiopathology HS remains unclearly understood, but considered polygenic autoinflammation condition originating from follicular hyperkeratosis occlusion. Recent advances concerning substantial roles tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐17,...
Microvascular decompression (MVD) is a standard surgical procedure for treating vascular compression syndromes. There are two basic ways to perform MVD: interposition using prosthesis and transposition. With the transposition technique, adhesions granuloma around site avoided, but required operation more complex than that method. We describe simple, quick MVD uses small "belt" cut from sheet of 0.3-mm-thick expanded polytetrafluoroethylene membrane. The belt has hole at wide end other...
This report describes results from our analysis of the activity and biodistribution a novel pan-ERBB inhibitor, NT113, when used in treating mice with intracranial glioblastoma (GBM) xenografts. Approaches this investigation include: bioluminescence imaging (BLI) for monitoring tumor growth response to therapy; determination survival benefit treatment; IHC reactivity indication treatment effect on proliferation apoptotic response; Western blot effects ERBB signaling mediator activation;...
1H-MRS is a non-invasive technique used to assess the metabolic activity of brain tumors. The useful for preoperative prediction tumor grade, which important treatment planning and accurate prognosis. We study lactate peak, appears in various conditions, including hyperglycemia, ischemia, hypoxia lipid associated with necrotic cells. purpose this was retrospectively examine frequency significance peaks relation grade.Fifty-five patients diagnosed neuroepithelial tumors Grades I (3 cases), II...
We report biodegradable temperature-triggered covalent gelation systems exhibiting a longer and controllable duration time of the gel state by “mixing strategy” utilizing thiol–ene reaction.
The efficacy of intravenous administration 400 mg carboplatin/m2 body surface area over 60 minutes combined with hyperbaric oxygenation (HBO) therapy (0.2 MPa for min) was investigated in 6 Japanese patients (aged 36-67 years) malignant or brainstem gliomas. Plasma ultra-filtrate samples were analyzed by high-performance liquid chromatography to evaluate the relationship between and pharmacokinetics. Brain tumor response evaluated magnetic resonance imaging as a function maximum plasma...
We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to covalent bond formation through thiol-ene reaction. In vitro sustained GLP-1 an IP formulation (F(P1/D+PA40)) was observed compared with reversible (physical gelation) (F(P1)). Moreover, pharmaceutically active levels were maintained in blood after subcutaneous injection into rats. system should...
Biodegradable injectable polymer (IP) systems that form hydrogels in situ when injected into the body have considerable potential as medical materials. In this paper, we report a new two-solution mixed biodegradable IP system utilizes stereocomplex (SC) formation of poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA). We synthesized triblock copolymers PLLA poly(ethylene glycol), PLLA-b-PEG-b-PLLA (tri-L), graft copolymer dextran (Dex) attached to PDLA-b-PEG diblock copolymer,...
Background: Intravenous thrombolysis and mechanical thrombectomy are the first-line reperfusion therapies for acute ischemic stroke. Here, we describe utility of diffusion magnetic resonance imaging (MRI) fiber tractography 123I-iomazenil benzodiazepine receptor single-photon emission computed tomography to estimate prognosis post-stroke aphasia after successful therapy. Case report: An 81-year-old man was admitted hospital approximately 3.5 h onset symptoms, including decreased...
Clazosentan prevents vasospasms after aneurysmal subarachnoid hemorrhage (SAH). However, clinical data on patients with SAH ruptured vertebral artery dissecting aneurysms (VADAs) are limited. We report the case of a 49-year-old male patient mild-grade (WFNS grade 1) thick and diffuse (modified Fisher 3) who underwent endovascular trapping VADA, resulting in poor functional outcome modified Rankin Scale score 4 due to severe symptomatic vasospasm refractory clazosentan, requiring repeated...
The organic films containing metal particles were prepared by rf ion plating system. was evaporated during plasma polymerization of monomer, in order to make polymer–metal composite materials. obtained observed transmission electron microscopy study the structures, and measured x-ray photoelectron spectroscopy find ratio components. These found have mixed carbide. Moreover, these showed characteristics semiconductorlike electrical properties.
The low-density lipoprotein cholesterol (LDL-C)/high-density (HDL-C) ratio is considered to be a sensitive marker of the risk atherosclerotic cardiovascular disease; however, in patients with previous history percutaneous coronary intervention (PCI), there little information regarding predictive value this parameter beyond period early restenosis. aim study was investigate contributing factors newly developed artery disease PCI after stabilization.The clinical characteristics 238 who...
Liposarcoma is one of the most common soft tissue sarcomas; however, early diagnosis rare as tumor remains difficult and unpalpable for a prolonged period time.Here we report first case retroperitoneal liposarcoma associated with pregnancy expression estrogen receptor. A 34-year-old woman experienced persistent abdominal distension after her delivery. Computed tomography (CT) magnetic resonance imaging (MRI) revealed large (40cm×35cm), solid, palpable mass fat attenuation displacing...
Intracerebral metastasis in osteosarcoma is extremely rare. A 14-year-old girl who had previously been operated upon for of the femur presented with seizures and left hemiparesis. right parietal lesion calcification brain oedema was found. After resection mass, pathology revealed an metastasis.
The case was a 51-year-old man, who has been undergoing treatment with oral medication for hypertension three years. patient admitted to the author's clinic hemorrhage in left putamen. He diagnosed as having primary pheochromocytoma of bladder from such symptoms paroxysmal blood pressure elevation after urination, mild increase catecholamine levels before and results 131I-MIBG scintigraphy, cystoscopy, underwent excision tumor. Upon endocrinological examination, only increases were found....
On clinical application of biodegradable injectable polymer (IP) systems, quick extemporaneous preparation IP formulations and longer duration time gel state after injection into the body are important targets to be developed. Previously, we had reported temperature-responsive covalent gelation systems via bio-orthogonal thiol-ene reaction by 'mixing strategy' amphiphilic tri-block copolymer (tri-PCG) attaching acryloyl groups on both termini (tri-PCG-Acryl) with reactive polythiol. In other...