A5069126645- Drug Transport and Resistance Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Bartonella species infections research
- Cardiovascular Health and Disease Prevention
- Sarcoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Analytical Chemistry and Chromatography
- Metabolism and Genetic Disorders
- Vascular Malformations Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- RNA Interference and Gene Delivery
- Pharmacogenetics and Drug Metabolism
- Soft tissue tumor case studies
- Advanced MRI Techniques and Applications
- Rabies epidemiology and control
- Bone Tumor Diagnosis and Treatments
- Neuroscience and Neuropharmacology Research
- Pituitary Gland Disorders and Treatments
- Tracheal and airway disorders
- Viral Infections and Vectors
- Radiopharmaceutical Chemistry and Applications
- Cancer Treatment and Pharmacology
St. Marianna University School of Medicine
2013-2025
Tokuyama (Japan)
1995-2024
Toray Industries, Inc. (Japan)
2012-2024
Toray (United States)
2008-2017
Yokohama City Seibu Hospital
2011-2017
Toshiba (Japan)
2017
PhoenixBio (Japan)
2017
Max Planck Institute for Informatics
2016
Hoshi University
2014
Harvard University
2012-2013
Using liquid chromatography/electrospray ionization mass spectrometry, we have found three unconjugated bile acids [cholic acid (CA), chenodeoxycholic (CDCA), and deoxycholic (DCA)] in the rat brain cytoplasmic fraction. CDCA was detected only upon extraction with high concentrations of guanidine, indicating that it is bound noncovalently to protein brain. The most abundant three, present at a concentration 1.6 nmol/g wet weight (∼15 mg protein) brain, corresponding almost 30 times its serum...
A noninvasive method for the characterization of cardiomyocyte contractile behavior is presented. Light microscopic video images cardiomyocytes were captured with a high-speed camera, and motion vectors (which have velocity dimension) calculated high spatiotemporal resolution using block-matching algorithm. This could extract contraction relaxation motions separately evaluate characteristics such as beating rate, orientation contraction, cooperativity/homogeneity in monolayer, wave...
Background: The transradial approach (TRA) using a Simmons catheter has increasingly been employed for diagnostic cerebral angiography and neurointervention. Typically, the right radial artery is used in neurointerventions. However, interventional cardiology, left TRA demonstrated clear clinical benefits, particularly right-handed patients. To our knowledge, no studies have directly compared carotid stenting (CAS). This study aimed to evaluate safety technical feasibility of TRA-CAS...
Objective. Kawasaki disease (KD) is one of the common causes cervical lymphadenopathy during early childhood. The purpose this study was to compare ultrasonographic feature lymph nodes in patients with KD, bacterial lymphadenitis, and infectious mononucleosis. Design. We studied 22 8 presumed 5 Epstein-Barr virus examined by ultrasonography using a 7.5-MHz or 10-MHz transducer B-mode sector scanner all chief complaint fever visible mass fixed time interval (July 1995-March 2000). Results. In...
The influence of transporters on the pharmacokinetics drugs is being increasingly recognized, and DDIs via may be a risk factor for adverse events. Cyclosporine A, strong OATP inhibitor, has been reported to increase systemic exposure rosuvastatin, an substrate, by 7.1-fold in clinical studies. PXB mice are chimeric with humanized livers that highly repopulated human hepatocytes have widely used drug discovery metabolism In present study, we examined vivo vitro between rosuvastatin...
The clinical management of cancer reflects a balance between treatment efficacy and toxicity. While typically, combination therapy improves response rate time to progression compared with sequential monotherapy, it causes increased Consequently, in cases advanced cancer, emerging guidelines recommend as means enhance quality life. An alternative approach that could overcome nonspecific toxicity while retaining therapeutic efficacy, involves the chemotherapy targeted therapy. In current...
The interest in transporter-mediated drug interactions has been increasing the field of development. In this study, we measured plasma and urinary concentrations coproporphyrin (CP) I CP III as endogenous substrates for organic anion-transporting polypeptide (OATP) using chimeric mice with human hepatocytes (PXB mice) examined influence an OATP inhibitor, rifampicin (RIF). were actively taken up intracellularly, RIF inhibited uptake a concentration-dependent manner both (PXB-cells). Single...
ABSTRACT Fourteen of 41 patients (34%) with a serological diagnosis Bartonella henselae infection were found to have prolonged fever or unknown origin, suggesting that generalized systemic B. is not rare in immunocompetent healthy individuals.
Abstract The ability to monitor breast cancer initiation and progression on the molecular level would provide an effective tool for early diagnosis therapy. In present study, we focused underglycosylated MUC‐1 tumor antigen (uMUC‐1), which is directly linked from pre‐malignancy advanced malignancy in has been identified as independent predictor of local recurrence response chemotherapy. We investigated whether changes uMUC‐1 expression during development therapeutic intervention could be...
Microvascular decompression (MVD) is a standard surgical procedure for treating vascular compression syndromes. There are two basic ways to perform MVD: interposition using prosthesis and transposition. With the transposition technique, adhesions granuloma around site avoided, but required operation more complex than that method. We describe simple, quick MVD uses small "belt" cut from sheet of 0.3-mm-thick expanded polytetrafluoroethylene membrane. The belt has hole at wide end other...
1H-MRS is a non-invasive technique used to assess the metabolic activity of brain tumors. The useful for preoperative prediction tumor grade, which important treatment planning and accurate prognosis. We study lactate peak, appears in various conditions, including hyperglycemia, ischemia, hypoxia lipid associated with necrotic cells. purpose this was retrospectively examine frequency significance peaks relation grade.Fifty-five patients diagnosed neuroepithelial tumors Grades I (3 cases), II...
Background: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute illness in children. Clinical burden each infection on distress asthmatic patients remains unclear. The purpose study was to clarify effect these infections severity children seasonal outbreaks. Methods: A total 1,217 pediatric inpatients with hMPV (n = 114) or RSV 1,103) Yamaguchi prefecture, Japan, between 2011 2014 were enrolled. Bronchial asthma defined as having more than 3...
A 4-year-old girl with systemic juvenile rheumatoid arthritis had Bartonella infection diagnosed serologically. This case suggested that (most probably henselae ) may in part be responsible for the development of arthritis.
Our patient presented with a mass lesion mimicking meningioma. The was resected, but pathological examination confirmed foreign body granuloma, which caused by silk fibres used as tenting sutures 8 years previously. Herein, we describe the case and review neurosurgical literature on intracranial granulomas.
Malignant ascites manifests as an end‐stage event during the progression of a number cancers and lacks generally accepted standard therapy. Interferon‐β ( IFN ‐β) has been used to treat several cancer indications; however, little is known about efficacy ‐β on malignant ascites. In present study, we report development novel, engineered form human murine ‐β, each conjugated with polyethylene glycol molecule PEG ‐ hIFN mIFN respectively). We provide evidence that these molecules retain...
Intracerebral metastasis in osteosarcoma is extremely rare. A 14-year-old girl who had previously been operated upon for of the femur presented with seizures and left hemiparesis. right parietal lesion calcification brain oedema was found. After resection mass, pathology revealed an metastasis.