A5072261919- Synthetic Aperture Radar (SAR) Applications and Techniques
- Cancer, Lipids, and Metabolism
- Advanced SAR Imaging Techniques
- Prostate Cancer Treatment and Research
- Glutathione Transferases and Polymorphisms
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Trypanosoma species research and implications
- CRISPR and Genetic Engineering
- Soil Moisture and Remote Sensing
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Insect symbiosis and bacterial influences
- Cryospheric studies and observations
- Optical measurement and interference techniques
- Antenna Design and Optimization
- RNA regulation and disease
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Urinary and Genital Oncology Studies
- Gut microbiota and health
University at Buffalo, State University of New York
2018-2024
Jacobs Institute
2023
Chinese Academy of Sciences
2012-2014
Institute of Electronics
2012-2014
University of Chinese Academy of Sciences
2014
Abstract Motivation Cancer subtype classification has the potential to significantly improve disease prognosis and develop individualized patient management. Existing methods are limited by their ability handle extremely high-dimensional data influence of misleading, irrelevant factors, resulting in ambiguous overlapping subtypes. Results To address above issues, we proposed a novel approach disentangling eliminating factors leveraging power deep learning. Specifically, designed...
In this letter, a fast backprojection algorithm (FBPA) is proposed for bistatic synthetic aperture radar imaging. For range compression, the signal recorded by synchronization channel of receiver on ground used as matched filter to compress echo signal. This method can reduce requirements satellite-orbit measurement and precision. azimuth secondary phase correction implemented effect caused approximation involved in FBPA. The computational complexity O(N <sup...
Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification multiplex molecular signatures associated disease has potential address this deficiency and assist accurate, non-invasive diagnosis monitoring.To evaluate performance Oncuria™, immunoassay for detection voided urine samples. test was evaluated multi-institutional cohort 362 prospectively collected subjects presenting cancer evaluation. parallel...
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<p>Construction of combined model.</p>
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Both in quality-guide phase unwrapping algorithms and weighted minimum-norm algorithms, quality maps play a crucial role obtaining the absolute from wrapped ones. In this letter, new technique for generating based on gray level co-occurrence matrix (GLCM) is proposed. GLCM classical second-order statistics method analyzing texture features of images. Through exploring GLCM, much useful information image can be exploited. According to characteristics interferogram, statistic called...
In the traditional processing flow of interferometric synthetic aperture radar (SAR) technique, phase is conducted via two separated and successive steps, i.e., denoising unwrapping. That to say, first, wrapped phases without noise are generated, then, true 2π-ambiguities reconstructed (here in rest this paper, refers information-induced unwrapped noise). Such steps will inevitably bring extra estimation error because each step has necessary approximations presumptions which do not always...
Uridine insertion/deletion RNA editing is an essential process in kinetoplastid parasites whereby mitochondrial mRNAs are modified through the specific insertion and deletion of uridines to generate functional open reading frames, many which encode components respiratory chain. The roles numerous non-enzymatic factors have remained opaque given limitations conventional methods interrogate order mechanism by progresses thus individual proteins. Here, we examined whole populations partially...
Interferometric phase denoising is a crucial step of interferometric synthetic aperture radar processing flow because it has significant influence on the following steps. Traditional algorithms have similar drawback that they will wipe off some texture details in images while denoising. Nonlocal (NL) means filter, contrast, can reach balance between and preserving utilizes feature recursive structures whole image. Taking characteristics image into consideration, this letter proposes modified...
The flexible geometry configuration of the bistatic synthetic aperture radar (SAR) has many advantages. However, it causes serious measurement error in SAR system, which degrades quality images and precision digital elevation model (DEM) obtained using stereoscopy SAR. In this paper, influence scene height estimation error, trigger delay, transmitter position receiver transmission line length are analyzed. These analyses very useful system design. synchronization affect both DEM by slightly....
Accumulating evidence suggests that the sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) pathway plays a pivotal role in colon carcinogenesis. Our previous studies indicate SphK1/S1P mediates carcinogenesis at least by regulating cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production. However, mechanisms which this regulates are still unclear. First, we show SphK1 deficient mice significantly attenuated azoxymethane (AOM)-induced as measured tumor incidence,...
The trypanosome R NA e diting s ubstrate binding c omplex (RESC) acts as the platform for mitochondrial uridine insertion/deletion RNA editing and facilitates protein–protein protein–RNA interactions required process . RESC is broadly comprised of two subcomplexes: GRBC ( g uide b inding omplex) REMC m ediator omplex). Here, we characterize function position in organization a previously unstudied protein, MRB7260. We show that MRB7260 forms numerous RESC-related complexes, including novel,...
Most mitochondrial mRNAs in kinetoplastids require extensive uridine insertion/deletion editing to generate translatable open reading frames. Editing is specified by trans-acting gRNAs and involves a complex machinery including basal accessory factors. Here, we utilize high-throughput sequencing analyze progression two minimally edited that provide simplified system due their requiring only each for complete editing. We show CYb MURF2 exhibit barriers differ from those previously identified...
Abstract Mitochondrial U-indel RNA editing in kinetoplastid protozoa is directed by trans-acting gRNAs and mediated a holoenzyme with associated factors. Here, we examine the function of holoenzyme-associated KREH1 helicase editing. We show that knockout (KO) impairs small subset mRNAs. Overexpression helicase-dead mutants results expanded impairment across multiple transcripts, suggesting existence enzymes can compensate for KO cells. In depth analysis defects using quantitative RT-PCR...
As with any biological process, cancer development is inherently dynamic. While major efforts continue to catalog the genomic events associated human cancer, it remains difficult interpret and extrapolate accumulating data provide insights into dynamic aspects of disease. Here, we present a computational strategy that enables construction progression model using static tumor sample data. The developed approach overcame many technical limitations existing methods. Application breast revealed...
Abstract The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, acting as an inhibitor tissue plasminogen and urokinase-type activator, impacting fibrinolysis. Recent studies have revealed a pro-tumorigenic role PAI-1 in human cancers, via the regulation angiogenesis tumor cell survival. In this study, immunohistochemical staining 939 bladder cancer specimens showed that expression levels correlated with grade, stage overall typical subcellular...