A5008987026- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- FOXO transcription factor regulation
- Sirtuins and Resveratrol in Medicine
- Diabetes Management and Research
- Viral Infectious Diseases and Gene Expression in Insects
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Calcium signaling and nucleotide metabolism
- Extracellular vesicles in disease
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Mitochondrial Function and Pathology
- Monoclonal and Polyclonal Antibodies Research
- Bariatric Surgery and Outcomes
- Diet, Metabolism, and Disease
- Marine Toxins and Detection Methods
- Peptidase Inhibition and Analysis
Spintronics Research Network of Japan
2022-2025
The University of Tokyo
2004-2025
Gunma University
2015-2024
Ochanomizu University
2023-2024
Tokyo University of Science
1993-2023
Nissan Chemical Corporation (Japan)
2023
Osaka University
1991-2021
High Energy Accelerator Research Organization
2021
Juntendo University
2013
Nikkiso (Japan)
2013
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 -R2 serve receptors for adiponectin mediate increased fatty acid oxidation glucose uptake adiponectin. In the present study, we examined expression levels roles of AdipoR1/R2 in several physiological pathophysiological states such fasting/refeeding, obesity, insulin resistance. Here show target organs, skeletal muscle liver, significantly...
Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles and proteins, is associated with pathogenesis various diseases such as cancer, neurodegeneration metabolic disease. Trehalose, a naturally occurring nontoxic disaccharide found in plants, insects, microorganisms invertebrates, but not mammals, was reported to function mechanistic target the rapamycin (mTOR)-independent inducer autophagy. In addition, trehalose functions an antioxidant though its underlying...
microRNAs (miRNAs) stably exist in circulating blood and are encapsulated extracellular vesicles such as exosomes. The aims of this study were to identify which exosomal miRNAs highly produced from epithelial ovarian cancer (EOC) cells, analyze whether serum miRNA can be used discriminate patients with EOC healthy volunteers, investigate the functional role progression.Exosomes collected culture media serous cell lines, namely TYK-nu HeyA8 cells. An microarray revealed that several including...
Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of and its role pathologies obese tissue, we focused on lysosomal function, protease maturation activity, both vivo vitro. First, showed that autophagosome formation was accelerated, but autophagic clearance impaired tissue. We also found protein activity levels CTSL (cathepsin L) were suppressed while the CTSB B) significantly enhanced. Moreover, cellular senescence...
It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role SGLT1 cells also unclear. We aimed to elucidate these points that are important not only for basic research but clinical insight. Plasma levels were assessed the high-fat, high-sucrose diet (HFHSD) fed C57BL/6J mice treated with dapagliflozin or canagliflozin. RT-PCR, RNA sequence, and immunohistochemistry conducted test...
Abstract Ovarian cancer is largely diagnosed at advanced stages upon detection of multiple peritoneal dissemination, resulting in poor outcomes. CD47 overexpressed tumors, facilitates tumor immune evasion, and located on exosomes. We aimed to investigate the role exosomal ovarian progression. Prognostic significance expression was examined using a public database including 1,435 patients validated with 26 our institution. associated progression-free survival inversely correlated macrophage...
Adiponectin, a pleiotropic cytokine, exerts its effects via the specific receptors AdipoR1 and AdipoR2. Whereas circulating adiponectin concentrations decrease in women with endometriosis endometrial cancer, possible of presence endometrium have not been determined. In this study, we examined expression AdipoR2 human assessed cells. Expression tissues was evaluated by real-time quantitative PCR, situ hybridization, Western blotting. The on phosphorylation AMP-activated protein kinase,...
Silent information regulator (SIR)2 is an nicotinamide adenine dinucleotide dependent deacetylase implicated in the regulation of life span species as diverse yeast, worms, and flies. Mammalian Sirt1 most closely related homolog SIR2 gene. Pharmacological activators have been reported to increase improve health mice fed a high-fat diet reverse diabetes rodents. links energy availability status with cellular metabolism peripheral organs including liver, pancreas, muscle, white adipose tissue....
Obesity is associated with ageing and increased energy intake, while restriction of intake improves health longevity in multiple organisms; the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1) implicated this process. Pro-opiomelanocortin (POMC) agouti-related peptide (AgRP) neurons arcuate nucleus (ARC) hypothalamus are critical for balance regulation, level SIRT1 protein decreases age ARC. In current study we tested whether conditional Sirt1 overexpression mouse POMC or AgRP prevents...
microRNAs (miRNAs) stably exist in circulating blood encapsulated extracellular vesicles such as exosomes; therefore, serum miRNAs have the potential to serve novel cancer biomarkers. New diagnostic markers detect high grade serous ovarian (HGSOC) are urgently needed. The aim of this study was identify specific HGSOC and analyze whether miRNA can discriminate patients from healthy controls or with malignancies other histological types.Exosomes cell lines were collected exosomal extracted....
Chirality-induced current-perpendicular-to-plane magnetoresistance (CPP-MR) originates from current-induced spin polarization in molecules. The is widely recognized as a fundamental principle of chiral-induced selectivity (CISS). In this study, we investigate chirality-induced current-in-plane (CIP-MR) chiral molecule/ferromagnetic metal bilayer at room temperature. contrast to CPP-MR, CIP-MR observed the present study requires no bias charge current through molecule. temperature dependence...
Imeglimin is a recently approved oral antidiabetic agent that improves insulin resistance, and promotes secretion from pancreatic β-cells. Here, we investigated the effects of imeglimin on glucagon α-cells.
In liver, glucose utilization and lipid synthesis are inextricably intertwined. When availability exceeds its utilization, lipogenesis increases, leading to increased intrahepatic content lipoprotein secretion. Although the fate of three-carbon metabolites is largely determined by flux rate through relevant enzymes, insulin plays a permissive role in this process. But mechanism integrating receptor signaling with unknown. Forkhead box O1 (FoxO1), downstream effector signaling, central...
Diabetes is characterized by an absolute or relative deficiency of pancreatic β-cells. New strategies to accelerate β-cell neogenesis maintain existing β-cells are desired for future therapies against diabetes. We previously reported that forkhead box O1 (FoxO1) inhibits growth through a Pdx1-mediated mechanism. However, we also FoxO1 protects failure via the induction NeuroD and MafA. Here, investigate physiological roles in pancreas generating mice with deletion domains Pdx1 promoter...
Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved activation lipid metabolism, enhancement mitochondrial biogenesis, reduction oxidative stress white adipose tissue (WAT). In studies using genetically modified mice with extended lifespans, WAT characteristics influenced mammalian lifespans. However, molecular mechanisms underlying CR-associated remain...
Diet affects health through ingested calories and macronutrients, macronutrient balance span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use peripheral tissues. Here, we show neuronal SIRT1 shifts choice from sucrose to mice, matching metabolic shift. SIRT1-mediated suppression simple sugar...
Abstract Rare‐earth iron garnets (RIG, R 3 Fe 5 O 12 ) are insulating ferrimagnets with high inversion symmetry because of their centrosymmetric cubic crystal structure. However, this centrosymmetry can be reduced by introducing a non‐uniform strain, leading to tetragonally distorted lattice In study, the strain‐induced distortions and symmetry‐breaking features investigated in compressively strained Sm tensile‐strained Lu thin films around critical thicknesses. Experiments indicate that...
Understanding the mechanisms that regulate cellular identity and proliferation is crucial for elucidating functions. Under normal conditions, pancreatic endocrine cells express only a single hormone, their numbers are tightly regulated. Contrary to this general principle, our study revealed significant increase in glucagon (GCG) polypeptide (PP) double-positive (GCG + PP cells), along with hyperplasia of both α proglucagon-deficient mice. Similarly, systemic receptor-deficient mice exhibited...
Abstract Flexible organic photodiodes (OPDs) are used to detect light in system‐scale demonstrations of skin‐conformable devices. However, the detectivity OPDs deteriorates under various environmental conditions, such as irradiation, air exposure, and heating. This decrease is observed with a widely sol–gel ZnO (ZnO SG) electron transport layer (ETL), where dark current at reverse bias increased by several orders magnitude. In this study, low stable respect aforementioned external changes...